Microsoft word - asx435 further validation of bnc210 .docx
ABN 53 075 582 740 ASX ANNOUNCEMENT 10 May 2011 INDEPENDENT STUDY PROVIDES FURTHER VALIDATION OF BNC210 FOLLOWING RECENT SUCCESS OF PHASE Ib TRIALS
• Study shows key link between the effectiveness of antidepressants and neurogenesis (the growth of new neurons in the brain) • Encouraging support for the clinical development of BNC210 which has been shown to have anti-anxiety and antidepressant effects and potent enhancement of neurite outgrowth in primary neurons 10 May 2011, Adelaide, Australia: Bionomics Limited (ASX: BNO) (ADR: BMICY) A recent research study conducted by an international team led by Dr Alexandre Surget of the Norwegian University of Science and Technology has demonstrated a key link between the effectiveness of antidepressants and neurogenesis (the growth of new neurons in the brain). The research study, which has been published in the journal Molecular Psychiatry, describes an animal model of unpredictable chronic mild stress that produces depressed behaviour in mice and demonstrates the importance of neurogenesis for the ability of antidepressant compounds to reverse this depression. Stress is an important cause of anxiety disorders and depressive illness in humans, and the same effects can be seen in mice. The stressed mice, who displayed overt signs of depression including weight loss and poor coat condition, were found to be producing fewer neurons in a part of the the brain called the dentate gyrus. The researchers found that giving the mice fluoxetine (marketed as Prozac) for five weeks while they were under the stressful conditions overcame the effects of stress and reduced their depression. The key discovery in this research was that the antidepressant only worked if the dentate gyrus, in the brain, was able to generate new neurons. The research provides encouraging support for the clinical development of BNC210: BNC210 has been shown to have potent enhancement of neurite outgrowth in primary
neurons, an indicator of neurogenic activity and a classic hallmark of antidepressant activity;
The effect of BNC210 on neurite outgrowth is more potent than BDNF, one of the body’s
endogenous neurotrophins (nerve growth factors); and
BNC210 is particularly effective in reducing the symptoms of stress. This has been
shown in animal models of heightened stress, which has been induced either pharmacologically or environmentally.
Commenting on the results of the research, Dr Deborah Rathjen, CEO & Managing Director of Bionomics, noted “the findings of this independent research provide encouraging support for the clinical development of BNC210 which has all of the important properties necessary for successful treatment of anxiety and depression. In particular BNC210 works well in
situations involving stress, including in the recent Phase Ib trial where BNC210 reduced panic symptoms and speeded recovery following the administration of the stress and panic- inducing agent CCK”. “BNC210 shows antidepressant activity in animal models of depression and it also potently promotes neurite outgrowth, an indication of neurogenic activity. An advantage of BNC210 is that it is faster acting than marketed drugs such as Prozac,” she added. To review the scientific publication copy the following details into your web browser: nature.com/mp/journal/vaop/ncurrent/full/mp201148a.html FOR FURTHER INFORMATION PLEASE CONTACT: Bionomics Limited Monsoon Communications The Trout Group
About Bionomics Limited Bionomics (ASX: BNO) is a leading international biotechnology company which discovers and develops innovative therapeutics for cancer and diseases of the central nervous system. Bionomics has small molecule product development programs in the areas of cancer, anxiety, epilepsy and multiple sclerosis. BNC105, which is undergoing clinical development for the treatment of cancer, is based upon the identification of a novel compound that potently and selectively restricts blood flow within tumours. A clinical program is also underway for the treatment of anxiety disorders and depression based on BNC210 which has recently completed Phase Ib clinical trials. Both compounds offer blockbuster potential if successfully developed. Bionomics' discovery and development activities are driven by its three technology platforms: Angene®, a drug discovery platform which incorporates a variety of genomics tools to identify and validate novel angiogenesis targets (involved in the formation of new blood vessels). MultiCore® is Bionomics' proprietary, diversity orientated chemistry platform for the discovery of small molecule drugs. ionX® is a set of novel technologies for the identification of drugs targeting ion channels for diseases of the central nervous system. These platforms underpin Bionomics’ established business strategy and Bionomics is committed to securing partners for its key compounds. For more information about Bionomics, visit www.bionomics.com.au Factors Affecting Future Performance
This announcement contains "forward-looking" statements within the meaning of the United States’ Private Securities Litigation Reform Act of I995. Any statements contained in this press release that relate to prospective events or developments are deemed to be forward-looking statements. Words such as "believes," "anticipates," "plans," "expects," "projects," "forecasts," "will" and similar expressions are intended to identify forward-looking statements. There are a number of important factors that could cause actual results or events to differ materially from those indicated by these forward-looking statements, including risks related to the clinical evaluation of either BNCI05 or BNC2I0, our available funds or existing funding arrangements, a downturn in our customers' markets, our failure to introduce new products or technologies in a timely manner, regulatory changes, risks related to our international operations, our inability to integrate acquired businesses and technologies into our existing business and to our competitive advantages, as well as other factors. Subject to the requirements of any applicable legislation or the listing rules of any stock exchange on which our securities are quoted, we disclaim any intention or obligation to update any forward-looking statements as a result of developments occurring after the date of this press release.
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