Material Safety Data Sheet CAFFEINE Revised: 11/18/2011 Replaces: 11/17/2011 Printed: 06/21/2013 Section 1 - Product Description Product Name: Caffeine Product Code(s): 85-1568, 85-1570 Size: 25 g, 100 g Chemical Name: 1,3,7,-Trimethylxanthine CAS Number: 58-08-2 Formula: C8H10N4O2 Synonyms: No-Doz, Coffeine, Theine Distributor: Carolina Biological Supply Company, 2700 York Road, Burlington, NC 27215 Chemical Information: 800-227-1150 (8am-5pm (ET) M-F) Chemtrec 800-424-9300 (Transportation Spill Response 24 hours) Section 2 - Hazard Identification Emergency Overview: Harmful: danger of serious damage to health by prolonged exposure if swallowed. Potential Health Effects: Eyes: May cause irritation. Skin: May cause irritation to skin. Ingestion: May cause gastrointestinal discomfort. Inhalation: May cause irritation to respiratory tract. Section 3 - Composition / Information on Ingredients Principal Hazardous Components: Caffeine, anhydrous (CAS# 58-08-2) 100% TLV units: N/A PEL units: N/A Section 4 - First Aid Measures Emergency and First Aid Procedures: Eyes - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Skin - After contact with skin, take off immediately all contaminated clothing, and wash immediately with plenty of water. Ingestion - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label. If
swallowed, rinse mouth with water (only if the person is conscious). Inhalation - In case of accident by inhalation: remove casualty to fresh air and keep at rest. Section 5 - Firefighting Procedures Flash Point (Method Used): > 93.3?C (CC) NFPA Rating: Health: 2 Fire: 1 Reactivity: 0 Extinguisher Media: Use media suitable to extinguish surrounding fire. Flammable Limits in Air % by Volume: N/A Autoignition Temperature: N/A Special Firefighting Procedures: Firefighters should wear full protective equipment and NIOSH approved self-contained Unusual Fire and Explosion Hazards: Fire or excessive heat may produce hazardous decomposition products. Explosive when mixed with oxidising substances. Section 6 - Spill or Leak Procedures Steps to Take in Case Material Is Released or Spilled: Ventilate area of spill. Clean-up personnel should wear proper
protective equipment. Avoid creating dust. Sweep or scoop up and containerize for disposal. Section 7 - Special Precautions Precautions to Take in Handling or Storing: Avoid creating and inhaling dust. Take off immediately all contaminated clothing. Keep container tightly closed in a cool, well-ventilated place. Section 8 - Protection Information Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation. A NIOSH/MSHA chemical cartridge respirator should be worn if PEL or TLV is exceeded. Ventilation: Local Exhaust: Yes Mechanical(General): Yes Special: No Other: No Protective Gloves: Natural rubber, Neoprene, PVC or equivalent. Eye Protection: Splash proof chemical safety goggles should be worn. Other Protective Clothing or Equipment: Lab coat, apron, eye wash, safety shower. Section 9 - Physical Data Molecular Weight: 194.19 Melting Point: Sublimes at 238 ?C Boiling Point: 178 ?C Vapor Pressure: N/A Vapor Density(Air=1): N/A Specific Gravity (H2O=1): 1.23 at 18 ?C Percent Volatile by Volume: N/A Evaporation Rate (BuAc=1): N/A Solubility in Water: Slightly Soluble Appearance and Odor: White, odorless crystals. Section 10 - Reactivity Data Stability: Stable Conditions to Avoid: Heat and sources of ignition. Incompatibility (Materials to Avoid): Oxidizers, Bases, Hazardous Decomposition Products: COx, NOx, Hazardous Polymerization: Will not occur Section 11 - Toxicity Data Toxicity Data: orl-rat LD50 192 mg/kg Effects of Overexposure: Acute: See Section 2 Chronic: Mutation data cited. Reproductive data cited. Not listed as a carcinogen by IARC, NTP or OSHA. Conditions Aggravated by Overexposure: Cardiovascular system Target Organs: N/A Primary Route(s) of Entry: Inhalation and ingestion. Section 12 - Ecological Data EPA Waste Numbers: N/A Section 13 - Disposal Information Waste Disposal Methods: Dispose in accordance with all applicable Federal, State and Local regulations. Always contact a
permitted waste disposer (TSD) to assure compliance. Section 14 - Transport Information DOT Proper Shipping Name: UN2811, Toxic solids, organic, n.o.s.(caffeine), 6.1, III Section 15 - Regulatory Information EPA TSCA Status: On TSCA Inventory Hazard Category for SARA Section 311/312 Reporting: Acute Name List: Chemical Category: CERCLA Section 103 RQ(lb.): Caffeine - No RCRA Section 261.33: Caffeine - No Section 16 - Additional Information
The information provided in this Material Safety Data Sheet represents a compilation of data drawn directly from various sources available to us. Carolina Biological Supply makes no representation or guarantee as to the suitability of this information to a particular application of the substance covered in the Material Safety Data Sheet. Any employer must carefully assess the applicability of any information contained herein in regards to the particular use to which the employer puts the material.
American Conference of Governmental Industrial Hygienists
CAS Number Chemical Services Abstract NumberCERCLA
Comprehensive Environmental Response, Compensation, and Liability Act
International Agency of Research on Cancer
Occupational Safety and Health Administration
Superfund Amendments and Reauthorization Act
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darunavir 400mg tablets (Prezista®) SMC No. (707/11) Janssen 08 July 2011 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in Scotland. The advice is summarised as follows: ADVICE : following a full submission darunavir (Prezista®) 400mg is accepted f