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Leo A. Paquette was born in Worcester, Massachusetts. He
received his BS degree from Holy Cross Col ege in 1956
and his Ph.D. in Organic Chemistry from MIT in 1959. After serving as a Research Associate at the Upjohn Company
from 1959 to 1963, he joined the faculty of The Ohio State University. He was promoted to ful professor in 1969, held the KimberlyProfessorship from 1981-1987 and was named Distinguished University Professor in 1987.
A member of the National Academy of Sciences since 1984, Dr. Paquette has been a Visiting Professor at institutions across the United States and Europe. He has served in an advisory capacity for advisory committees of the National
Institutes of Health and the National Science Foundation, and has been a member of the editorial boards of numerous
publications including the Journal of Organic Chemistry, Journal of the American Chemical Society, Organic
Syntheses, Organic Reactions, and as the head editor of the
Electronic Encyclopedia of Organic Reagents (eEros).
Dr. Paquette’s other honors include Sloan Fellow, Guggenheim Fel ow, ACS Award for Creative Work in Synthetic Organic Chemistry, Arthur C. Cope Scholar Award
of the ACS, the S.T. Li prize for Science and Technology
and he was chosen as the Centenary Lecturer of the Royal
Chemical Society, just to name a few. He has been a fel ow
of the Japanese Society for the Promotion of Science, and has been selected to serve as the Plenary Lecturer for more
than a dozen international conferences. He is also the recipient of an honorary doctorate from his alma mater.
According to a nominator for one of his many awards, Dr. Paquette’s prolific career has resulted in remarkable
contributions to numerous areas of relevance in the broad field of organic chemistry, including synthesis and properties of unusual molecules, natural products total synthesis, new synthetic methodology, rearrangement processes and
stereoelectronic control. In the field of hydrocarbon chemistry, Dr. Paquette is best known for achieving the first total synthesis of the Platonic solid dodecahedrane in 1982, which stil stands as one of the landmark achievements in the history of organic synthesis and hydrocarbon chemistry.
Dr. Paquette is the author of more than 1260 papers, 38 book chapters, 17 books (including edited volumes), and an encyclopedia, owns 40 patents, and has guided close to 150 graduate students to Ph.D. degrees.
Prof. Liotta received his Ph.D. in Organic Chemistry in 1974 from The City
Stephen L. Buchwald was born (1955) in Bloomington, Indiana. He
University of New York and completed his post-doctoral training at The Ohio
received his Sc.B. degree from Brown University in 1977 where he
State University. Dr. Liotta has been a professor at Emory University for
worked with Kathlyn A. Parker and David E. Cane at Brown University
thirty-two years. He is a Fel ow of the Alfred P. Sloan Foundation, the recipient of a Camil e and Henry Dreyfus Teacher Scholar Fel owship, an
as wel as Professor Gilbert Stork at Columbia University. He entered Harvard University as a National Science Foundation Predoctoral Fel ow
Alexander von Humboldt Senior Scientist Award, the 2005 Herty Award, and
in 1977 and received his Ph.D. in 1982. His thesis work, with Jeremy R.
was the Emory University Distinguished Faculty Lecturer for 2006. While at
Knowles, concerned the mechanism of phosphoryl transfer reactions in
Emory, he has authored more than two hundred research publications and
chemistry and biochemistry. He then was a Myron A. Bantrel patents. Over the last fifteen years he has also developed a great deal of
postdoctoral fel ow at Caltech with Professor Robert H. Grubbs where he
experience in the discovery and development of pharmaceuticals. He has
studied titanocene methylenes as reagents in organic synthesis and the
served as a consultant to several major pharmaceutical firms, including Merck, Glaxo, Burroughs Wel come, Boehringer Ingelheim and Johnson & Johnson.
mechanism of Ziegler-Natta polymerization. In 1984 he began as an
assistant professor of chemistry at MIT. He was promoted to the
Along with his col eague, Raymond Schinazi, he was the recipient of the 2003 Biomedical Industry Growth Award, given by the Georgia Biomedical
associate professor (1989) and to Professor (1993) and was named the Camil e Dreyfus Professor in 1997. During his time at MIT he has
Partnership. He serves (or has served) on the Scientific Advisory Boards
received numerous honors including the Harold Edgerton Faculty
(SABs) of several prominent biopharmaceutical companies including Meta
Achievement Award of MIT, an Arthur C. Cope Scholar Award, the 2000
Statix (SAB Chair), AtheroGenics, Pharmasset (scientific founder), iThemba
Award in Organometal ic Chemistry from the American Chemical
Pharmaceuticals (scientific founder, SAB Chair), NeurOp, and FOB Synthesis. In addition, he is the inventor of record for several clinical y important
"Transition Metal-Catalyzed Carbon-Carbon and Carbon-
Society, a MERIT award from the National Institutes of Health. He has
Heteroatom Bond-Forming Processes: Progress, Applications
also been the recipient of the Bristol-Myers Squibb Distinguished
antivirals, including FTC (Emtriva, Emtricitabine), 3TC (Epivir, Lamivudine),
Achievement Award and the CAS Science Spotlight Award, both Reverset (DPC 817, D-D4FC), Racivir and Elvucitabine.
received in 2005 and the American Chemical Society's Award for Crea-
tive Work in Synthetic Organic Chemistry as wel as the Siegfried Medal
Award in Chemical Methods which Impact Process Chemistry, both
“C-H: A New Functional Group for Streamlining Synthesis “
received in 2006. In 2000, he was elected as a fellow of the American
Michael Martinel i received his undergraduate degree from the State University
Academy of Arts and Sciences and in 2008 he was elected as a
of New York at Geneseo, doing research with Professor Richard F. Smith. He
member of the National Academy of Science. He is the coauthor of
then obtained his Ph.D. under the guidance of Professor Peter Jacobi from
over 310 published or accepted papers and 39 issued patents. He
Wesleyan University in 1984, resulting in the total synthesis of Saxitoxin.
serves as a consultant to a number of companies.
Postdoctoral research at the University of Munich, with Professor Rudolf
Gompper through 1985 was fol owed by an NIH Fel owship at Harvard
University with Professor Yoshito Kishi, 1986-7, culminating in the total
“New Therapies for Cancer & Inflammation”
synthesis of Palytoxin. He then joined the Chemical Process R&D group at Eli
M. Christina White was born in Athens, Greece. She is currently an
Lil y and Company, where he worked to advance numerous programs from the
Associate Professor of Chemistry at the University of Il inois at Urbana-
preclinical phase through clinical development. He led the team that
Champaign. Professor White completed her PhD studies at Johns
commercialized Cialis, using novel technology. In 2003, he moved west to assemble the Process R&D group for smal molecules at Amgen in California,
Hopkins University as an ACS predoctoral fel ow and postdoctoral studies at Harvard University with Professor Eric Jacobsen as an NIH
and then on to build the Pharmaceutical Development organization at Arena,
“Perspectives on Process Research in the Pharmaceuti-
postdoctoral fel ow. She has received numerous awards including the
where serves as Vice President. He has more than 65 publications and 70
Camil e and Henry Dreyfus New Faculty Award (2002), the NSF patents, with more than 70 invited lectures. He is presently on the Editorial
Board for Organic Reactions, is referee for more than twelve journals and on
CAREER Award (2006), the Eli Lil y Grantee Award (2007), the Alfred P. Sloan Research Fel owship (2008-2010), the Pfizer Award for Creativity
the organizing committee for several international conferences and research
in Organic Chemistry (2008), BMS Unrestricted “Freedom to Discover”
Grant (2008), Amgen Young Investigator Award (2008), Camil e Dreyfus
"Catalytic Asymmetric Synthesis: Hydrovinylation of
Teacher-Scholar Award (2008), AstraZeneca Excel ence in Chemistry
Alkenes and Ring Opening Reactions of Aziridines "
Award (2008), Abbott Young Investigator Award (2008), and the Roche
Excel ence in Chemistry Award (2009). Professor White’s research group
T. V. (Babu) RajanBabu received his undergraduate education in India (Kerala
is focused on the discovery, development, and study of predictable and
University and Indian Institute of Technology, Madras). He obtained a Ph. D.
highly selective C—H functionalization methods and their strategic use in
degree from The Ohio State University under the direction of Professor Harold
streamlining the process of complex molecule synthesis.
Shechter, and was a postdoctoral fel ow at Harvard University with the late
Professor R. B. Woodward. He then joined the Research Staff of Dupont Central Research and Development. He returned to Ohio State as a Professor of Chemistry in 1995.
PRESENTACIÓN Ponemos a disposición de los lectores la edición de la ALERTA PERIODISTICA correspondiente a agosto de 2010. Como es sabido, se trata de una recopilación de las principales informaciones de carácter económico divulgadas por la prensa nacional durante el mes anterior. En este caso, un rápido vistazo al contenido nos dice que los principales tópicos que constituyeron not
Syllabus rationale This is a narrative explaining how the syllabus is structured and how the main capabilities are linked. The rationale also explains in further detail what the This syllabus and study guide is designed to help with planning study and to provide detailed Detailed syllabus information on what could be assessed in This shows the breakdown of the main capabilities (se