Summarized from Koi Health and Disease , by Erik L. Johnson, DVM
This material was excerted by Spike Cover and if it's messed up, it's his fault <grin>
Fish Length11 Injectible medication dose (cc @ given strength) Trade Name Amikacin1 Sterile Saline2 Azactam3 Baytril4 Cefotan5 Chloramphenicol6 Dexamethasone7 Gentamicin1 Rocephin10 generic name See note 12 Strength Injection Route(s) Dosing: See notes Weight based dosing
Amikacin - Inject every other day (EOD) for no more than 3 injections, specifically avoiding the use of Gentamicin; if fish show any signs of spasticity, stop injections immediately and avoid stressing the fish. Also see note 12.
Sterile saline added to Amikacin when given IP to aid the dispersion of the drug thru the peritoneal space
Azactam - inject daily for 3 days, then EOD for 3 more injections. Reconstitute with sterile saline (0.9% salt). Keeps for 7 to 14 days under refrigeration afterreconstituting. Very effective against Pseudomonas.
Baytril - given IP with 25 ga needle. Inject daily for 3 injections, then EOD for 2 more injections. Effective against Pseudomonas.
Cefotan - Inject daily for 3 injections, then EOD for 3 more injections. Reconstituted med good for 4 days if kept refrigerated, only 1 day if at room temp.
Chloramphenicol - Inject daily for 3 injections, then EOD for 3 more injections. CAUTION - Chloramphenicol can cause Grays Syndrome in humans. Reconstituted drug starts to lose potency after 7 to 14 days if not refrigerated. ELJ implies that reconstituted Chloramphenicol can be kept by freezing.
Dexamethasone - given to fish in sever shock. Not an antibiotic. See p. 68 of Koi Health and Disease for indications for use.
Nexcel - very forgiving in both in both dose and interval. IP preferred route. Inject daily or EOD for 3 to 5 injections. Store reconstituted drug up to one month under refrigeration.
Nuflor - ELJ initially used IM injections but now says IP works well. Some large kohaku have turned bright red post IM injection and the speculation is that it was theresult of sun sensitivity due to the antibiotic. Best given with 20 ga needle (medication is very viscous).
Rocephin - same dosing regimen as Chloramphenicol - see Note 6 above.
Fish length includes the tail, i.e., it is the total length of the fish (this does not apply to long-finned koi or butterfly koi)
Gentamicin has been found to be frequently VERY toxic especially when given IP. Information on ELJ's web page says (as of 1-1-05), " Never use Gentamicin. It's toxic in a dose or two."
This dosing of Gentamicin is far less than the dosing recommended by ELJ based on length. Professional and amateur fish fixers report better results from IM and/or lower dosing
Taken from Advanced Koi Care , by Nick Saint-Erne - page 163
Injectible Meds Recommended dosing Route(s)
Intraperitoneal (actually intracoelomic in fish)
Management of Common Opioid-Induced Adverse Effects JOHN M. SWEGLE, PHARM.D., Mercy Family Medicine Residency Program, Mason City, Iowa CRAIG LOGEMANN, PHARM.D., Urbandale Family Physicians, Urbandale, Iowa Opioid analgesics are useful agents for treating pain of various etiologies; however, adverse effects are potential limita- tions to their use. Strategies to minimize adverse effect
J. Med. Chem. 2001, 44, 2432-2437 Discriminating between Drugs and Nondrugs by Prediction of Activity Spectra for Substances (PASS) Soheila Anzali,*,† Gerhard Barnickel,† Bertram Cezanne,† Michael Krug,† Dmitrii Filimonov,‡ andVladimir Poroikov‡ Bio- and Chemoinformatics Department, Merck KGaA, Darmstadt D-64271, Germany, and Institute of Biomedical Chemistryof Russian Acade