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Matrìca SpA • Zona Industriale “La Marinella” I-07046 Porto Torres • Telefono:+39.079.509000 • Fax:+39.079.509257 • www.matrica.it
Material safety data sheet
According to Reg. EC 1907/2006, Reg. EC 1272/2008, Reg. EC 453/2010 SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
AZELAIC ACID
Monomer, intermediate, for industrial use only. Matrìca S.p.A.
Zona Industriale “La Marinella” I-07046 Poto Torres (SS), Italy 1.4. EMERGENCY TELEPHONE NUMBER: CENTRI ANTIVELENI: SECTION 2: HAZARDS IDENTIFICATION

2.1. CLASSIFICATION OF THE SUBSTANCE OR
Classification according to Reg. n.1272/2008: Skin Irritant Cat. 2
H315: Causes skin irritation.
Eye Irritant Cat. 2
H319: Causes serious eye irritation.
Classification according to 67/548/EEC: Xi: Irritant R36/38: Irritating to eyes and skin. Warning H315: Causes skin irritation H319: Causes serious eye irritation REGULATION (EC) No 1907/2006 AZELAIC ACID
Date of Issue: September 26th, 2013 Page 1 of 8
Date of Revision:
Revision Nr.: 1
Version Nr.: 1.0
Matrìca SpA • Zona Industriale “La Marinella” I-07046 Porto Torres • Telefono:+39.079.509000 • Fax:+39.079.509257 • www.matrica.it
P280: Wear protective gloves and eye and face protections. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P332 + P313: If skin irritation occurs: Get medical attention. P362: Take off contaminated clothing and wash before reuse. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313: If eye irritation persists: Get medical attention. Powder may cause respiratory irritation; powder may form explosive mixtures with air.
SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS


3.1. SUBSTANCES:
SECTION 4: FIRST AID MEASURES

4.1. DESCRIPTION OF FIRST AID MEASURES:
Rinse cautiously with water for several minutes with the eyelid held wide open. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation occurs: get medical attention and show to him/her this Safety Data Sheet. Immediately take off contaminated clothing and wash the skin with plenty of soap and water. Wash clothes before reuse. If skin irritation occurs: get medical attention and show to him/her this Safety Data Sheet. Rinse mouth thoroughly. Get medical attention. Move victim to fresh air and keep at rest in a position comfortable for breathing. If difficulties occur, consult a physician. Wear protective gloves and clothes. If large release occurs also wear eye and face protection. (Refer to section 8 for personal protection). IF IN EYES: can cause serious eye irritation. IF SWALLOWED: in large quantities can cause digestive tractb irritation. IF INHALED: can cause respiratory irritation. 4.3. INDICATION OF ANY IMMEDIATE MEDICAL Get medical attention if inhaled, ingested, or if irritation occurs after eye or skin contact. SECTION 5: FIREFIGHTING MEASURES
REGULATION (EC) No 1907/2006 AZELAIC ACID
Date of Issue: September 26th, 2013 Page 2 of 8
Date of Revision:
Revision Nr.: 1
Version Nr.: 1.0
Matrìca SpA • Zona Industriale “La Marinella” I-07046 Porto Torres • Telefono:+39.079.509000 • Fax:+39.079.509257 • www.matrica.it
Toxic gases, such as oxides of carbon may be released during combustion. The substance, as shipped, does not pose any dust explosion hazard. Nevertheless, powder of 75µm or less may pose dust explosion hazard if particular conditions are present, such as ignition sources, sparks. Foam, water spray, dry chem may be used for fire extinguishment. Surroundings exposed to intense heat deriving from fire should be kept cool with water to prevent fire spreading. Remove other combustible materials from fire area if possible. Stay upwind, keep out of low areas. Wear goggles and a positive pressure self-contained breathing apparatus and full protective equipment.
SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1. PERSONAL PRECAUTIONS, PROTECTIVE
EQUIPMENT AND EMERGENCY PROCEDURES: In case of accidental release do not walk on the contaminated area and avoid any contact and further spread of the substance. Avoid dispersion caused by wind. Keep non trained personnel away from the area where the accidental release took place. Remove any flame and ignition source. Wear adequate clothing to proceed to cleaning up. Refer to section 8 for personal protection. Avoid dispersion of substances in drains, surface and ground water. For small spill: Use normal good housekeeping procedures for clean-up of substance trying to avoid dust formation and dispersion. For large spill: use mechanical equipment, such as a shovel. Try to avoid dust formation and dispersion. Place into drums or other suitable container for disposal. Flush with water or vacuum-clean the contaminated area after removal of substance. Substance is water soluble: if a large quantity of substance is accidentally released in water inform authorities.
SECTION 7: HANDLING AND STORAGE
7.1. PRECAUTIONS FOR SAFE HANDLING:
Electrically bond & ground all containers, if relevant, and equipment before transfer or use of substance. Handle in well-ventilated areas. Avoid dust generation and deposition. In case of dust generation be equipped with approved dust mask. Do not breath dust. Do not eat, drink and smoke in the areas where material is stored, handled, processed. Personnel handling the material should wash hands before eating, drinking and smoking. 7.2. CONDITIONS FOR SAFE STORAGE, INCLUDING REGULATION (EC) No 1907/2006 AZELAIC ACID
Date of Issue: September 26th, 2013 Page 3 of 8
Date of Revision:
Revision Nr.: 1
Version Nr.: 1.0
Matrìca SpA • Zona Industriale “La Marinella” I-07046 Porto Torres • Telefono:+39.079.509000 • Fax:+39.079.509257 • www.matrica.it
Ensure that bags, drums or other container are not damaged and are well closed. Store in cool (below 50°C), dry, well-ventilated, area away from heat sources, flame, spark sources, moisture, acid, alkaline or oxidizing materials. SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1. CONTROL PARAMETERES:
Good industrial hygiene should be adopted. Provide general and/or local exhaust ventilation. Avoid inhalation of dust by installing a local aspiration where relevant in the equipment or wear respiratory protection (see below). Provide flowing water and eye washing equipment. Wear suitable industrial clothing depending on the kind of processing in order to avoid skin contact. Wear approved protection gloves, according to EN 374 and EN 388, depending on the kind of processing/manipulation. If dust generation occurs, use approved dust mask European Classification Filter, P1, P2, P3 depending on dust particle size. SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1. INFORMATION ON BASIC PHYSICAL AND CHEMICAL PROPERTIES
NOT APPLICABLE. The substance is a solid. 1.07E-08 mm Hg @ 25°C (extrapolated from experimental values) NOT APPLICABLE. The susbtance is a solid. PARTITION COEFFICIENT N-OCTANOL/WATER: 1,57 (Log Kow) REGULATION (EC) No 1907/2006 AZELAIC ACID
Date of Issue: September 26th, 2013 Page 4 of 8
Date of Revision:
Revision Nr.: 1
Version Nr.: 1.0
Matrìca SpA • Zona Industriale “La Marinella” I-07046 Porto Torres • Telefono:+39.079.509000 • Fax:+39.079.509257 • www.matrica.it
NOT APPLICABLE. The substance is a solid. Substance has no chemical groups associated with explosive properties. According to column 2 of Annex VII of Reg. 1907/2006 (REACH) the study does not need to be performed. Substance has no chemical groups associated with oxidizing properties. According to column 2 of Annex VII of Reg. 1907/2006 (REACH) the study does not need to be performed.
SECTION 10: STABILITY AND REACTIVITY
10.1. REACTIVITY:
Reacts with strong oxidizing agents, bases and strong acids Not expected in normal storage and use conditions Flames, ignition sources, excessive heat. Strong oxidizing agents, bases and strong acids. SECTION 11: TOXICOLOGICAL INFORMATION

11.1. INFORMATION ON TOXICOLOGICAL EFFECTS:
read across with OTTANOIC ACID (CAS 124-07-2) read across with OTTANOIC ACID (CAS 124-07-2) LC50 INHALATION, RAT > 0.1621 mg/L air read across with STARIC ACID (CAS 57-11-4) AZELAIC ACID is not skin irritating at concentrations up to 50% in a guinea pig test according to OECD 406. The liquid analogue FATTY ACIDS, C8-C10 (CAS 68937-75-7) is skin irritating in a rabbit test according to OECD 404 (degree of purity > 99.5%). Based on above results, AZELAIC ACID is classified as skin irritant in concentrations above 50%. Rabbit study on the analogue: C10: 96.6 %; C12: 2.6 %; C8: 0.8 %, shows corneal opacity and moderate conjunctivitis which do not subside within 72 h. Based on above results, AZELAIC ACID is classified as eye irritant. REGULATION (EC) No 1907/2006 AZELAIC ACID
Date of Issue: September 26th, 2013 Page 5 of 8
Date of Revision:
Revision Nr.: 1
Version Nr.: 1.0
Matrìca SpA • Zona Industriale “La Marinella” I-07046 Porto Torres • Telefono:+39.079.509000 • Fax:+39.079.509257 • www.matrica.it
SKIN: AZELAIC ACID is not sensitizing in the guinea pig test according to OECD 406 at concentrations up to 50%. Also studies on analogues do not show sensitizing phenomena. No data available on germ cells. Experimental tests conduced on analogues show negative results in bacteria reverse mutation on S. typhimurium and genetic mutation and chromosome aberration tests on mammalian cells. No in vivo available experiments. In vitro experimental tests conduced on analogues show negative results in bacteria reverse mutation on S. typhimurium and genetic mutation and chromosome aberration tests on mammalian cells. DOCOSANOIC ACID (CAS 112-85-6) analogue does not show any adverse effects on rats maternal and foetal development at the maximum dose (1000 mg/kg bw) according to OECD 422. SECTION 12: ECOLOGICAL INFORMATION
12.1. TOXICITY :
Based on the Log Kow (PARTITION COEFFICIENT N-OCTANOL/WATER) of 1,57 the BCF (BIOCONCENTRATION FACTOR) of 3,162 can be estimated (BCFWINNT v.2.15). Therefore, Bioaccumulation potential is low. AZELAIC ACID has a pKa (DISSOCIATION CONSTANTS OF ORGANIC ACIDS IN AQUEOUS SOLUTION) of 4.53, hence, for soil pH values between 5 and 9 it will be mostly ionized with a preferred partition into water. Moreover, the estimation of Koc (ORGANIC CARBON ADSORPTION COEFFICIENT) form Pow show a low adsorption potential to soil. Based on the available information AZELAIC ACID does not respond to PBT and vPvB classification criteria. SECTION 13: DISPOSAL CONSIDERATIONS
REGULATION (EC) No 1907/2006 AZELAIC ACID
Date of Issue: September 26th, 2013 Page 6 of 8
Date of Revision:
Revision Nr.: 1
Version Nr.: 1.0
Matrìca SpA • Zona Industriale “La Marinella” I-07046 Porto Torres • Telefono:+39.079.509000 • Fax:+39.079.509257 • www.matrica.it
Dispose residues and packaging in accordance with local and state laws. Dispose of hazardous products according to European Waste Catalogue (EWC). SECTION 14: TRANSPORT INFORMATION

14.1. UN NUMBER:
ANNEX II OF MARPOL73/78 AND THE IBC CODE: SECTION 15: REGULATORY INFORMATION
Reg. 1907/2006/EC (REACH), Reg. 1272/2008/EC (CLP) Dir. 67/548/EEC SECTION 16: OTHER INFORMATION
The present Safety Data Sheet is written according to Annex II of Reg. (EC) No 1907/2006 (REACH) as amended by Annex I of Reg. (EC) No 453/2010 and is referred to the pure substance AZELAIC ACID. If the substance is used as a component of a mixture or reacted to form a new substance, the present Safety Data Sheet cannot be considered automatically as valid. Any revision is indicated by (#). Acronyms ACGIH = American Conference of Governmental Industrial Hygienists DNEL = Derived No Effect Level EC50 = Effective Concentration 50: concentration that causes a certain effect in 50% of a population EINECS = European Inventory of Existing Commercial chemical Substances ErC50 = EC50 (growth rate): EC50 biomass growth of aquatic plants LC50 = Lethal Concentration 50: concentration that causes the death of 50% of population LD50 = Lethal Dose 50: dose that causes the death of 50% of population NOAEL = No Observed Adverse Effect Level: dose or concentration without adverse effect OECD = Organization for Economic Co-operation and Development REGULATION (EC) No 1907/2006 AZELAIC ACID
Date of Issue: September 26th, 2013 Page 7 of 8
Date of Revision:
Revision Nr.: 1
Version Nr.: 1.0
Matrìca SpA • Zona Industriale “La Marinella” I-07046 Porto Torres • Telefono:+39.079.509000 • Fax:+39.079.509257 • www.matrica.it
OSHA PEL = Occupational Safety and Health Administration-Permissible Exposure Limit
PNEC = Predicted No Effect Concentration
TLV = Threshold Limit Value
TWA = Time-Weighted Average
Bibliography:
Data are sourced from public databases, such as ECHA (European CHemical Agency) web-page.
DISCLAIMER:
The herein opinions and information are the result of our investigations and are given in good faith but no warranty,
express or implied, is made. The information refers to Azelaic acid as delivered by Matrìca SpA. Since the use of
these opinions and information and the conditions of use of the product are not under the control or supervision of
Matrìca SpA, it is the user’s responsibility to determine the safety and suitability for his own use of the product
described herein. To this purpose the recipient is invited to consider the present MSDS in the context of the
applicable laws and regulations of the country and area where the product is to be used. The products must be handled
only by trained personnel.
REGULATION (EC) No 1907/2006 AZELAIC ACID
Date of Issue: September 26th, 2013 Page 8 of 8
Date of Revision:
Revision Nr.: 1
Version Nr.: 1.0

Source: http://www.matrica.it/public/docs/azelaic_acid_ver_1_0_ss_en.pdf

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