Avocado Leaves Can Cure Kidney Stone http://news.ipb.ac.id Posted by admin on 03 September 2010
In addition to diabetes, kidney stone is one of the diseases that interfere with public health inIndonesia. According to Asnaldi (2008), patients with kidney stone disease were estimated tobe 13 % in adult men and 7 % in adult women in Indonesia. The worst excess of kidneystones is a permanent kidney damage or uremia.
Diuretic drug administration (the drug to quicken the formation of urine) can shed kidneystones smaller than 5 millimeters. Meanwhile kidney stones of more than 5 millimeters may betreated with Extracorporeal Shock Wave Lithotripsy (ESWL), Percutaneous Nephrolithotripsy(PCNL) and Ureteroscopy. ESWL technique is to use waves that can crush the kidneys fromoutside the patient's body. This technique is relatively safe, without injuring the patient,anesthesia and hospitalization. PCNL treatment is by making a hole to remove the kidneystones. Both ESWL and PCNL are affordable for everybody because they are quite expensiveand not many hospitals have the treatment facilities.
The extract of avocado leaves or Persea americana offers an alternative prevention from theformation of crystal that would become a kidney stone. Empirically, people have been usingavocado leaves as drugs for lowering high blood pressure, diabetes and kidney stones. Unfortunately the studies of avocado leaves are still very limited, so there is not muchscientific information about its pharmacological activity. For this reason, researchers from theDepartment of Clinic, Reproduction and Pathology, Faculty of Veterinary Medicine Dr. IetjeWientarsih, Rini Madyastuti P, Bayu Prasetyo and Lina Noviyanti Febram were interested toinvestigate the ability of avocado leaves to inhibit the formation of kidney crystal.
"This study was aimed to provide information on the diuretic ability of ethanol extract fromavocado leaves and its inhibiting force against the formation of kidney crystals particularlycalcium oxalate and the development of avocado leaves into standardized herbal orphytopharmaca," said Dr. Wientarsih. Calcium oxalate is the type of stone mostlyencountered, i.e. 75-80 % of all kidney stones.
This research was conducted for two years. In the first year, the ethanol extract was tested toinhibit the kidney crystals induced by certain chemicals. This study used 20 white male miceof Sprague Dawley. They were divided into three groups: normal, furosemide and treatment. Normal group (K1) did not receive any treatment. In the positive group (K2), mice wereinduced and given furosemide. In the treatment groups (K3 and K4), the induced mice wereorally given ethanol extracts of avocado leaves in different doses. The measurements of urinevolume were done at the 5th and 24th hour. "The result was that the group K3 showeddiuretic activity and this inhibited the formation of kidney crystal better than the furosemidegroup. This means that with the same dosage, the avocado leaf extract could inhibit crystalformation better than furosemide," said Dr. Wientarsih.
In the second year, the ethanol extract of avocado leaves was filtered using the solvents ethylacetate and n-hexane. Then, the fraction of ethyl acetate and n-hexane from the ethanol
extract of avocado leaves was tested on mice. The result was that this fraction indicated adiuretic activity and the most optimum inhibition against kidney crystals than furosemide. "Theavocado leaf extract contains flavonoids and potassium that can shed the kidney crystals,"said Dr. Wientarsih
Avocado leaf extract is made into three formulas of pharmaceutical tablets by wet granulationmethod and the three elixir formulas (sweet syrup). Three formulas of tablets were comparedin terms of crushing time based on the concentrations of the variable polivinilpirolidon (PVP)K30 i.e. 2.5 gram, 5 gram and 7.5 gram. The formula of 2.5 grams PVP K30 has the crushingtime that meets the requirements of Pharmacopoeia Indonesia, i.e. 14.21 minutes. Meanwhile, the three elixir formulas already tested have the alcohol concentration of 5%, 7.5% and 10% each. The formula with 7.5 % of alcohol indicates a stable specific gravity and thebest viscosity. (mtd)
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