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Medication Guide for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Get emergency help right away if you have any of the following
(See the end of this Medication Guide for a
· shortness of breath or trouble breathing
What is the most important information I should know about
medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?
· weakness in one part or side of your body
NSAID medicines may increase the chance of a heart attack or
stroke that can lead to death
. This chance increases:
Stop your NSAID medicine and call your healthcare provider right
away if you have any of the following symptoms:
NSAID medicines should never be used right before or after a heart
surgery called a “coronary artery bypass graft (CABG).”
NSAID medicines can cause ulcers and bleeding in the stomach and
intestines at any time during treatment. Ulcers and bleeding:
The chance of a person getting an ulcer or bleeding increases with:
· there is blood in your bowel movement or it is black and sticky
· taking medicines called “corticosteroids” and “anticoagulants”
· swelling of the arms and legs, hands and feet
These are not all the side effects with NSAID medicines. Talk to your
healthcare provider or pharmacist for more information about NSAID
NSAID medicines should only be used:
medicines. Call your doctor for medical advice about side effects. You
may report side effects to FDA at 1-800-FDA-1088 or Depomed, Inc. at
· at the lowest dose possible for your treatment
Other information about Non-Steroidal Anti-Inflammatory Drugs
What are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?
NSAID medicines are used to treat pain and redness, swelling, and heat
· Aspirin is an NSAID medicine but it does not increase the chance
(inflammation) from medical conditions such as:
of a heart attack. Aspirin can cause bleeding in the brain,
stomach, and intestines. Aspirin can also cause ulcers in the
· menstrual cramps and other types of short-term pain
· Some of these NSAID medicines are sold in lower doses without
Who should not take a Non-Steroidal Anti-Inflammatory Drug
a prescription (over-the-counter). Talk to your healthcare provid-
er before using over-the-counter NSAIDs for more than 10 days.
NSAID medicines that need a prescription
· if you had an asthma attack, hives, or other allergic reaction with
Generic Name Trade Name
· for pain right before or after heart bypass surgery
Tell your healthcare provider:
Cataflam, Voltaren, Arthrotec (combined with
· about all of your medical conditions.
· about all of the medicines you take. NSAIDs and some other
medicines can interact with each other and cause serious
side effects. Keep a list of your medicines to show to your
healthcare provider and pharmacist.
· if you are pregnant, NSAID medicines should not be used past
30 weeks of pregnancy.
Motrin, Tab-Profen, *Vicoprofen (combined with
· if you are breastfeeding, talk to your doctor.
hydrocodone), Combunox (combined with oxycodone)
What are the possible side effects of Non-Steroidal Anti-
Indocin, Indocin SR, Indo-Lemmon, Indomethagan
Inflammatory Drugs (NSAIDs)?
Serious side effects include:
Other side effects include:
Naprosyn, Anaprox, Anaprox DS, EC-Naprosyn,
Naprelan, Naprapac (copackaged with lansoprazole)
*Vicoprofen contains the same dose of ibuprofen as over-the-counter
(OTC) NSAIDs, and is usually used for less than 10 days to treat pain. The
· liver problems including liver failure
OTC NSAID label warns that long term continuous use may increase the
This Medication Guide has been approved by the U.S. Food and Drug
Zipsor® 2012 Depomed, Inc., Newark, CA 94560 USA All rights reserved. ZIP-052-P.2
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