Impotentie brengt een constant ongemak met zich mee, net als fysieke en psychologische problemen in uw leven https://zonder-voorschrift.com/cialis-zonder-recept.html terwijl generieke medicijnen al bewezen en geperfectioneerd zijn
¿Está buscando comprar Cialis en línea en España? Es importante asegurarse de que el sitio web que elija sea legítimo y seguro antes de realizar una compra. En comprar-farmacia.es, ofrecemos una amplia selección de medicamentos de calidad, incluido Cialis, para tratar la disfunción eréctil (DE).
Nuestro sitio web es fácil de usar y está diseñado para garantizar una experiencia de compra en línea segura y satisfactoria. Trabajamos con farmacias acreditadas y ofrecemos envío rápido y discreto para su comodidad.
También puede contar con nosotros para la privacidad de sus transacciones en línea. En comprar-farmacia.es, utilizamos tecnología de encriptación de datos de última generación para garantizar que sus transacciones sean seguras y privadas.
Si tiene preguntas o necesita ayuda para realizar un pedido, nuestro equipo de atención al cliente está disponible para ayudarlo en todo momento. Nos tomamos en serio su privacidad y solo ofrecemos medicamentos de alta calidad y auténticos.
Visite nuestro sitio web en comprar-farmacia.es para obtener más información sobre nuestros productos y servicios. Asegúrese de que su compra en línea de Cialis sea segura y confiable eligiendo comprar-farmacia.es como su farmacia en línea de confianza en España.
00_acupmed-toc.indd
Original paper
The effect of acupuncture on postmenopausal symptoms and reproductive hormones: a sham controlled clinical trial
Didem Sunay,1 Muruvvet Ozdiken,1 Huseyin Arslan,2 Ali Seven,3 Yalcin Aral4
ABSTRACT
system, accompanied with a series of psycho-
Background Acupuncture is commonly used to
logical symptoms.1 Oestrogen, either by itself
or with progestins is the most consistently
gynaecological conditions. In this study, the authors
Ministry of Health, Ankara Training and Research Hospital,
aimed to investigate whether acupuncture has an
However, the Women’s Health Initiative and
effect on menopausal symptoms and to explore
Million Women Study have identifi ed impor-
whether this effect is related to changes in hormone
tant risk factors (coronary heart disease, stroke,
breast and endometrial cancer) associated
with hormone replacement therapy (HRT).3–6
Materials and methods A total of 53
postmenopausal women were alternately assigned
Those fi ndings have led to an expanded inter-
into two treatment groups: acupuncture (n=27)
est in non-hormonal therapies for managing
symptoms were assessed using the Menopause
Correspondence to
only limited data to support their use. The
Rating Scale (MRS). The serum oestradiol, follicular
common conclusion in reviews regarding to
stimulating hormone (FSH) and luteinising hormone
complementary and alternative therapies for
(LH) levels were measured at baseline and again
the management of menopause related symp-
after the fi rst and last sessions. The Student t test
toms was that the data were insuffi cient to
was used for normally distributed data and the
recommend any alternative therapy and fur-
Wilcoxon signed rank test for not normally
ther investigation was still needed.7 8 In the
distributed data. The group differences in MRS
area of complementary and alternative thera-
scores were assessed using non-parametric
pies, acupuncture and acupressure treatments
are promising, however, the results of pub-
Results After treatment, total MRS, and the
lished randomised controlled trials of the
somatic and psychological subscale scores were
effect of acupuncture on hormone levels and
signifi cantly lower in the acupuncture group than
the sham group (all p=0.001). The severity of hot
fl ushes was found to be signifi cantly decreased
after treatment in acupuncture group (p=0.001). In
the acupuncture group LH levels were lower and
multiple biological responses.16 17 These
oestradiol levels were signifi cantly higher than sham
responses can occur at or close to the site of
group (p=0.046 and p=0.045, respectively) after
application, or at a distance, mediated mainly
treatment, but there was no difference in FSH
by sensory neurons to many structures within
the central nervous system. This can lead to
Conclusion Acupuncture was effective in reducing
activation of pathways affecting various phys-
menopausal complaints when compared to sham
iological systems in the brain as well as in the
periphery. Stimulation by acupuncture may
alternative therapy in the treatment of menopausal
also activate the hypothalamus and the pitu-
itary gland, resulting in a broad spectrum of systemic effects. Alteration in the secretion of neurotransmitters and neurohormones and
INTRODUCTION
changes in the regulation of blood fl ow, both
Perimenopause syndrome, referred also as cli-
macteric syndrome, results from the changing documented.18of relationship among the hypothalamus,
pituitary and ovary during women’s ageing aimed to investigate whether acupuncture has process. Those changes take place fi rst in the an effect on menopausal symptoms and to ovary, then in the hypothalamus and pituitary,
explore whether this effect is related to
which are refl ected as the functional changes changes in levels of reproductive hormones. in the endocrinological and central nervous
Acupunct Med 2011;29:27–31. doi:10.1136/aim.2010.003285
Original paper MATERIALS AND METHODS
The secondary outcome measures were hormone lev-
After obtaining approval of the local ethical committee,
els. Hence, the baseline serum E2 (E2b), FSH (FSHb) and
56 postmenopausal women (50 naturally and six surgi-
luteinising hormone (LH; LHb) levels were recorded.
cally), who had been referred to the outpatient clinic of
These parameters were measured again after the fi rst
menopause at Ankara Training and Research Hospital,
(E2fs, FSHfs, LHfs) and last sessions (E2ls, FSHls, LHls) to
Ankara, Turkey, between October 2009 and December
evaluate whether the effect of intervention was cumula-
2009, for follow-up or treatment and who agreed to par-
tive. The fi rst session of interventions was applied 2–7 days
ticipate were included in this, single-blind, sham-con-
trolled study. All participants were informed about the
The acupuncture group received traditional Chinese med-
study and written consents were received. Participants
icine acupuncture twice a week for a total of 10 sessions by
were alternately assigned into two treatment groups: acu-
a licensed acupuncturist with 6 years experience. Sterile, dis-
puncture (n=28) and sham acupuncture (n=28). The age,
posable, silver needles with a length of 0.25×25 mm (Wujiang
menopausal age, body weight and height of all partici-
Jia Chan, Wujiang City, China) were used. The needles were
pants were recorded. Body mass index (BMI) was calcu-
inserted bilaterally at four acupuncture points (ST36, depth
lated by the formula body weight (kg)/height (m2).
1 cun; LI4, 0.5 cun; KI3, 0.2 cun; LR3, 0.3 cun) and also in the
The term postmenopausal was defi ned as: 12 months
points EX-HN3 at 0.1 cun depth and CV3, 0.5 cun; de qi sen-
spontaneous amenorrhea for women who still had a uterus,
sation was obtained with manipulation and the needles
and serum oestradiol (E2) levels lower than 50 pg/ml and
were then left for 20 min without any manual or electrical
serum follicular stimulating hormone (FSH) levels higher
stimulation. The points were located by the acupuncturist
than 40 IU/ml for women who had surgical menopause
according to WHO Standard Acupuncture Point Locations
and had no uterus. None of the participants had taken HRT
Sham acupuncture was performed on the sham group
The primary outcome of the study was an assessment
twice a week for a total of 10 sessions at the same points
of improvement in menopausal symptoms. Hence, meno-
by the same acupuncturist. Sham acupuncture needles
pausal symptoms were assessed using an 11 item Turkish
developed by Streitberger and Kleinhenz22 (Asia Med,
version of the Menopause Rating Scale (MRS).19 20 Three
Munich, Germany) were used. The blunted needles were
aspects were assessed from the menopausal symptoms:
inserted by using an O ring and adhesive dressing to avoid
somatic (four items), psychological (four items) and uro-
penetration to the skin. No other interventions were
genital (three items) symptom complexes. A 5-point rating
scale allowed the women to describe the perceived sever-
In relation to the reproductive hormones, we hypothe-
ity of symptoms for each item (severity: 0=no complaints
sised that the interventions would be considered effective
to 4=very severe symptoms). The composite scores for
if FSH and LH levels decreased and oestradiol levels
each dimension (subscale) are based on adding the item
scores in the respective dimensions. The composite score
Data were analysed using SPSS V.12. G-Power V.3.1
(total score) is the sum of the dimension scores.
software was used to evaluate sample size and power of
• Received allocated intervention (n=28)
• Received allocated intervention (n=27)
• Did not receive allocated intervention (n=0)
• Did not receive allocated intervention (n=0)
Lost to follow-up (unable to contact) (n=1)
Discontinued intervention (private reasons)
Figure 1 Flow diagram of the progress through the phases of the randomised trail. Acupunct Med 2011;29:27–31. doi:10.1136/aim.2010.003285
Original paper
the present study. Theoretical power was taken as 0.80 in
psychological and urogenital subscale scores (p=0.132,
planning the study and the power actually achieved was
p=0.066 and p=0.461, respectively). However, all subscale
calculated to be 0.71 at the end of the study. Descriptive
scores were signifi cantly decreased after therapy in the
statistics were expressed as mean±SD for continuously
measured variables. Student t test was used for normally
When the severity of hot fl ushes in somatic subscale
distributed data, and Wilcoxon signed rank test for not
was evaluated alone, a signifi cant difference was found
normally distributed data for comparisons in dependent
between groups, with scores in the acupuncture group sig-
groups. The group differences in MRS scores were assessed
nifi cantly lower than the sham group (p=0.001) after the
using non-parametric Mann–Whitney U test. Multivariate
last session. For the within group changes in severity of
analysis with Bonferroni correction was used posthoc to
hot fl ushes no signifi cant difference was observed in the
explore changes in FSH levels. A pvalue of 0.05 was con-
sham group (p=0.317), but there was a signifi cant decrease
The comparisons of hormone levels (baseline, after the
fi rst and last sessions) of groups are shown in table 3. In
In the acupuncture group, one patient left the study for
the acupuncture group, FSHb levels were higher than
personal reasons, in the sham group, one patient did not
sham group before treatment (p=0.002), which was con-
come to follow-ups and one patient did not meet the
inclusion criteria (she had surgical menopause with FSH
FSH levels of the acupuncture group were higher than
levels lower than 40 IU/ml). Hence, the study was com-
the sham group (p=0.009) after the fi rst treatment but not
pleted with 53 participants (27 in the study group, 26 in
at the end of the course of acupuncture (p=0.659). LH lev-
the sham group) analysed (fi gure 1). No adverse effects
els in the acupuncture group were signifi cantly lower after
were observed in any of the patients.
the fi rst treatment (p=0.036) and also at the end of the
The groups were similar in terms of mean age, mean
course (p=0.046). Oestrogen levels were signifi cantly
menopausal age and mean duration of menopause higher than in the sham group at the end of treatment (p=0.633, p=0.991 and p=0.760, respectively). Mean BMI
of the groups were also similar (p=0.186) (table 1).
Considering the changes within the groups before and
The MRS scores for the two groups are shown in table 2.
after interventions, no signifi cant differences were found
When total MRS scores of the groups were compared, no
between FSHbs and FSHls, LHb and LHls, E2b and E2ls
differences were found between the total scores of the
levels in acupuncture and sham groups (p=0.853, p=0.245,
groups after the fi rst session (p=0.115), but the total score
p=0.138, p=0.043, p=0.904 and p=0.695, respectively).
of the acupuncture group after the last treatment was sig-nifi cantly lower than the sham group (p=0.001). The uro-
DISCUSSION
genital subscale and hot fl ush severity scores were In the present study, total MRS scores as well as somatic signifi cantly different between groups at baseline, which
and psychological (but not urogenital) subscale scores of
was considered a random fi nding. Somatic subscale scores
acupuncture group were lower than sham group after
after the fi rst and last sessions were signifi cantly lower in acupuncture group than the sham group (both p=0.001). The psychological subscale scores after the fi rst session
Table 2 Menopause Rating Scale scores of the two groups
were similar in the two groups (p=0.626) whereas the scores after the last session were signifi cantly lower in
Acupuncture
acupuncture group than placebo group (p=0.001).
Mean±SD Mean±SD
Urogenital subscale scores of the groups were no different
(Min–Max) (Min–Max)
after the fi rst and last sessions (p=0.447 and p=0.153,
When the scores were compared before and after the
interventions (within groups), no signifi cant differences
were found in sham group in terms of somatic, Psychological
Table 1 The mean age, menopausal age, duration of
menopause and mean body mass index (BMI) of the groups
Acupuncture Mean±SD Mean±SD (Min–Max) (Min–Max)
bs, baseline; fs, fi rst session; ls, last session. Acupunct Med 2011;29:27–31. doi:10.1136/aim.2010.003285
Original paper Table 3 Hormone levels of groups at baseline and after the fi rst and the last sessions Acupuncture Mean±SD (Min–Max) Mean±SD (Min–Max)
Follicular stimulating hormone (FSH) FSH bs
*Multivariate analysis: no signifi cant effect of time (p=0.464) or group × time interaction (p=0.659). bs, baseline; fs, fi rst session; ls, last session.
treatment. LH levels were reduced and oestradiol levels
symptoms, such as vasomotor symptoms and vaginal or
were raised after treatment with acupuncture group, but
genital dryness, but also contributed to treatment-related
those we believe that those changes in hormone levels are
effects, such as bleeding and breast tenderness.26 27 Also
not suffi ciently large to explain the changes in symptoms.
different results have been reported in studies comparing
Most acupuncture studies in this topic have used similar
HRT with acupuncture for the treatment of menopausal
time frames for acupuncture sessions, but it is not clear
symptoms. In some of those, it was reported that symp-
whether the length of time chosen for treatment was suf-
toms decreased signifi cantly with both treatments,11 28 in
fi cient to refl ect acupuncture’s complete effect. Therefore
some of them better results with HRT,10 and in others
we assessed MRS scores and the hormone levels after the
with acupuncture12 13 have been reported.
fi rst session of interventions, to explore whether the effect
Among menopausal symptoms, the most prominent
of acupuncture was cumulative: we found that the differ-
symptom—and the one on which most studies have been
ences were greater after the last session than the fi rst
conducted—is hot fl ushes. The symptoms are characteris-
tic of a heat-dissipation response and consist of sweating
It was suggested in 1976 that acupuncture stimulation in
on the face, neck and chest, as well as peripheral vasodila-
normal ovulatory women may affect endocrine func-
tion. Although hot fl ushes clearly accompany oestrogen
tions.23 Later, the effect of acupuncture on ovulation induc-
withdrawal at menopause, oestrogen alone is not respon-
tion was investigated by Yu et al24 who found that ovulation
sible since levels do not differ between symptomatic and
was induced in fi ve of 11 women with chronic anovula-
asymptomatic women. Until recently, it was thought that
tory cycles, three of whom conceived. However, different
hot fl ushes were triggered by a sudden, downward reset-
results have been reported in studies examining the effect
ting of the hypothalamic thermoregulatory set-point, since
of acupuncture on postmenopausal hormone levels. In
there was no evidence of increased core body tempera-
some studies, where different acupuncture techniques and
ture. Evidence obtained using a rapidly responding
different HRT procedures were applied, signifi cantly
ingested telemetry pill indicates that the thermoneutral
decreased FSH and LH levels and increased oestradiol lev-
zone, within which sweating, peripheral vasodilation and
els were reported with acupuncture10–12 15 while in some, a
shivering do not occur, is virtually non-existent in symp-
signifi cant decrease in menopausal symptoms but no tomatic women but normal in asymptomatic women. The change in hormone levels were reported.9 Especially in
results suggest that small temperature elevations preced-
studies with electroacupuncture, more signifi cant results
ing hot fl ushes acting within a reduced thermoneutral
were obtained in hormone levels.12 25 Since we observed
zone constitute the triggering mechanism. Central sympa-
small changes in hormone levels similar to some studies,
thetic activation is also elevated in symptomatic women,
we speculate that acupuncture might have an effect on
which reduces the thermoneutral zone in animal studies.
reproductive hormones through some mechanisms that
Oestrogen virtually eliminates hot fl ushes but its mecha-
we could not explain. It is certain that further studies are
nism of action is not known.29 Acupuncture has been sug-
gested as an alternative to HRT, based on the fact that
In the present study somatic, psychological and urogen-
acupuncture increases central β-endorphin activity and
ital symptom subscale scores of MRS decreased with acu-
therefore may make the thermoregulation more stable
puncture therapy. In studies that have investigated the
and decrease hot fl ushes and sweating.28 In some studies
effect of HRT in treatment of menopausal symptoms, it
signifi cant decrease has been reported not in frequency
was reported that HRT relieved some menopausal but in severity of hot fl ushes with acupuncture.14 30 Like
Acupunct Med 2011;29:27–31. doi:10.1136/aim.2010.003285
Original paper
several other studies, in this study the severity of hot
4. Wassertheil-Smoller S, Hendrix SL, Limacher M, et al; Women’s Health Initiative
fl ushes was signifi cantly decreased in the acupuncture
Investigators. Effect of estrogen plus progestin on stroke in postmenopausal women: the Women’s Health Initiative: a randomized trial. JAMA 2003;289:2673–84.
group after treatment. However, in the acupuncture group,
5. Beral V; Million Women Study Collaborators. Breast cancer and hormone-replacement
signifi cant changes in hormone levels (especially in oestro-
therapy in the Million Women Study. Lancet 2003;362:419–27.
gen) were not observed and this suggests that other fac-
6. Beral V, Bull D, Reeves G; Million Women Study Collaborators. Endometrial cancer and
hormone-replacement therapy in the Million Women Study. Lancet
tors are activated in the causing hot fl ushes. In another
study,9 vasomotor and physical symptoms were found to
7. Nedrow A, Miller J, Walker M, et al. Complementary and alternative therapies for the
be improved with acupuncture, although no changes were
management of menopause-related symptoms: a systematic evidence review. Arch Intern Med 2006;166:1453–65.
found in sexual symptoms and reproductive hormones.
8. Borrelli F, Ernst E. Alternative and complementary therapies for the menopause.
In some studies comparing sham acupuncture to real
acupuncture, both forms of acupuncture therapy were
9. Dong H, Lüdicke F, Comte I, et al. An exploratory pilot study of acupuncture on
the quality of life and reproductive hormone secretion in menopausal women.
effective in the treatment of postmenopausal symp-
J Altern Complement Med 2001;7:651–8.
toms.25 28 Recently, Venzke et al31 reported that the sub-
10. Zhou J, Qu F, Sang X, et al. Acupuncture and auricular acupressure in relieving
jects obtained benefi t from either form of acupuncture
menopausal hot fl ashes of bilaterally ovariectomized Chinese women: a randomized controlled trial. Evid Based Complement Alternat Med 2009 (in press).
treatment and they suggested that non-invasive needling
11. Xia XH, Hu L, Qin ZY, et al. [Multicentral randomized controlled clinical trials about
might not be equivalent to no treatment or true placebo
treatment of perimenopausal syndrome with electroacupuncture of sanyinjiao (SP 6)].
treatment. However, in the present study, real acupunc-
Zhen Ci Yan Jiu 2008;33:262–6.
12. Jin H, Liu TT, Wang R. [Clinical observation on acupuncture at the fi ve-zangshu for
ture treatment was superior to sham acupuncture in the
treatment of perimenopausal syndrome]. Zhongguo Zhen Jiu 2007;27:572–4.
relief of somatic, and psychological symptoms in post-
13. Qu F, Zhou J, Nan R. Acupuncture for perimenopausal symptoms in women who
underwent oophorectomy a comparative study. Forsch Komplementmed 2007;14:25–32.
Despite the importance of the current fi ndings, several
14. Huang MI, Nir Y, Chen B, et al. A randomized controlled pilot study of acupuncture for
limitations must be mentioned. First the sample size was
postmenopausal hot fl ashes: effect on nocturnal hot fl ashes and sleep quality.
very small. Next, as we did not follow-up the patients
Fertil Steril 2006;86:700–10.
15. Shen X, Du Y, Yan L, et al. Acupuncture for treatment of climacteric syndrome – a
after the treatment we could not know whether the posi-
report of 35 cases. J Tradit Chin Med 2005;25:3–6.
tive effects of acupuncture especially on symptoms con-
16. Kim HY, Wang J, Lee I, et al. Electroacupuncture suppresses capsaicin-induced
tinue. More reliable results can be obtained in the studies
secondary hyperalgesia through an endogenous spinal opioid mechanism. Pain 2009;145:332–40.
with larger sample size and longer follow-up.
17. Arranz L, Guayerbas N, Siboni L, et al. Effect of acupuncture treatment on the immune
function impairment found in anxious women. Am J Chin Med 2007;35:35–51.
18. Anonymous. NIH consensus conference. Acupuncture. JAMA 1998;280:1518–24. CONCLUSION
19. Bekiroglu N, Konyalioglu R, Ayas S, et al. The comparison of Menopause Rating Scale
The current data indicate that acupuncture can be consid-
(MRS), Kupperman Index (KI) and Nottingham Health Profi le (NHP) by means of
ered as an alternative therapy in the treatment of meno-
reliability measures and responsiveness Indexes among menopausal women. Zeynep Kamil Tıp Bülteni 2008;39:11–16.
pausal symptoms particularly in hot fl ushes, in women
20. Potthoff P, Heinemann LA, Schneider HP, et al. [The Menopause Rating Scale (MRS II):
methodological standardization in the German population]. Zentralbl Gynakol 2000;122:280–6.
21. World Health Organization Western Pacifi c Region. WHO Standard Acupuncture Point
Locations in the Western Pacifi c Region. Manila: WHO, 2008:33–195. Summary points
22. Streitberger K, Kleinhenz J. Introducing a placebo needle into acupuncture research.
▶ Evidence is mixed on whether acupuncture is superior to
23. Aso T, Motohashi T, Murata M, et al. The infl uence of acupuncture stimulation on
sham in the treatment of hot fl ushes.
plasma levels of LH, FSH, progesterone and estradiol in normally ovulating women.
▶ We compared acupuncture with non-penetrating sham. Am J Chin Med (Gard City N Y) 1976;4:391–401.
24. Yu J, Zheng HM, Ping SM. [Changes in serum FSH, LH and ovarian follicular growth
▶ Acupuncture was superior for menopause symptom
during electroacupuncture for induction of ovulation]. Zhong Xi Yi Jie He Za Zhi
25. Vincent A, Barton DL, Mandrekar JN, et al. Acupuncture for hot fl ashes: a randomized,
sham-controlled clinical study. Menopause 2007;14:45–52. Competing interests None.
26. Barnabei VM, Cochrane BB, Aragaki AK, et al. Menopausal symptoms and
Ethics approval This study was conducted with the approval of the local ethical
treatment-related effects of estrogen and progestin in the Women’s Health Initiative.
Obstet Gynecol 2005;105:1063–73.
27. Welton AJ, Vickers MR, Kim J, et al. Health related quality of life after combined
Provenance and peer review Not commissioned; externally peer reviewed.
hormone replacement therapy: randomised controlled trial. BMJ 2008;337:a1190.
28. Zaborowska E, Brynhildsen J, Damberg S, et al. Effects of acupuncture, applied
relaxation, estrogens and placebo on hot fl ushes in postmenopausal women: an
REFERENCES
analysis of two prospective, parallel, randomized studies. Climacteric
1. Shang YJ, Zhang Y, Kong LL, et al. [Clinical observation on combination of source point
and Back-Shu Point for treatment of perimenopausal syndrome]. Zhongguo Zhen Jiu
29. Freedman RR. Physiology of hot fl ashes. Am J Hum Biol 2001;13:453–64.
30. Nir Y, Huang MI, Schnyer R, et al. Acupuncture for postmenopausal hot fl ashes.
2. McNagny SE. Prescribing hormone replacement therapy for menopausal symptoms.
Ann Intern Med 1999;131:605–16.
31. Venzke L, Calvert JF, Gilbertson B. A randomized trial of acupuncture for vasomotor
3. Manson JE, Hsia J, Johnson KC, et al; Women’s Health Initiative Investigators.
symptoms in post-menopausal women. Complement Ther Med 2010;18:59–66.
Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 2003;349:523–34. Acupunct Med 2011;29:27–31. doi:10.1136/aim.2010.003285
New Brunswick Prescription Drug Program Formulary: Appendix IV - Special Authorization New Brunswick Prescription Drug Program Formulary: Appendix IV - Special Authorization Drugs Excluded Bimatroprost (Lumigan) A-13Botulinum Toxin Type A (Botox) A-13Buserelin Acetate (Suprefact) A-14Capecitabine (Xeloda) A-15Celecoxib (Celebrex) A-16Ciprofloxacine (Cipro and generic brands) A-16Cipr