Syllabus for GPAT - 2013
Introduction to Physical pharmacy
State of matter, change in the state of matter, latent heats and vapor pressure, sublimation-
critical point, Eutectic mixtures, gases, aerosols-inhalers, relative humidity, liquid. Complexes,
liquid crystals, glassy state, solids- crystalline, amorphous and polymorphism.
Particle size and distribution, average particle size, number and weight distribution, particle
number, methods for determining particle volume, methods of determining particle size- optical
microscopy, sieving, sedimentation; measurements of particle shape, specific surface area;
methods for determining surface area; permeability, adsorption, derived properties of powders,
porosity, packing arrangement, densities, bulkiness & flow properties.
Liquid interface, surface and interfacial tensions, surface free energy, measurement of surface
and interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active
agents, HLB classification, solubilization, detergency, adsorption at solid interfaces, solid-gas and
solid-liquid interfaces, complex films, electrical properties of interface.
Newtonian systems, Law of flow, kinematic viscosity, effect of temperature; non-Newtonian
systems: pseudoplastic, dilatant, plastic; thixotropy, thixotropy in formulation, negative
thixotropy, determination of viscosity, capillary, falling ball, rotational viscometers.
Colloidal dispersions: Definition, types, properties of colloids, protective colloids, applications of colloids in
pharmacy; Suspensions and Emulsions: Interfacial properties of suspended particles, settling in suspensions,
theory of sedimentation, effect of Brownian motion, sedimentation of flocculated particles, sedimentation
parameters, wetting of particles, controlled flocculation, flocculation in structured vehicles, rheological
considerations; Emulsions-types, theories, physical stability.
Classification of complexes, methods of preparation, analysis, & applications.
General considerations & concepts, half-life determination, Influence of temperature, light,
solvent, catalytic species and other factors, Accelerated stability study, expiration dating.
Importance of microbiology in pharmacy
Structure of bacterial cell; Classification of microbes and their taxonomy:
Actinomycetes, bacteria, rickettsiae, spirochetes and viruses.
Stains and types of staining techniques, electron microscopy; Nutrition, cultivation, isolation of
bacteria, actinomycetes, fungi, viruses, etc; microbial genetics and variation.
Control of microbes by physical and chemical methods:
Disinfection, factors influencing disinfectants, dynamics of disinfection, disinfectants and
Different methods, validation of sterilization methods &equipments; Sterility testing of all
pharmaceutical products. Microbial assays of antibiotics, vitamins & amino acids.
Immunology and Immunological Preparations:
Principles, antigens and heptans, immune system, cellular/humoral immunity, immunological
tolerance, antigen-antibody reactions and their applications. Hypersensitivity, active and passive
immunization. Vaccines and sera: their preparation, standardization and storage.
Transformation, conjugation, transduction, protoplast fusion and gene cloning and their
applications.Development of hybridoma for monoclonal antibodies. Study of drugs produced by
biotechnology such as Activase, Humulin, Humatrope, HB etc.
Historical development of antibiotics. Antimicrobial spectrum and methods used for their
standardization. Screening of soil for organisms producing antibiotics, fermenter, its design,
control of different parameters. Isolation of mutants, factors influencing rate of mutation. Design
of fermentation process. Isolation of fermentation products with special reference to penicillins,
streptomycins, tetracyclines and vitamin B12.
Introduction to pharmaceutical jurisprudence & ethics
A brief review; Drugs & Pharmaceutical Industry - A brief review; Pharmaceutical Education
Pharmaceutical Ethics; Pharmacy Act 1948; Drugs and Cosmetics Act 1940 and Rules 1945;
Medicinal & Toilet Preparations (Excise Duties) Act 1955; Narcotic Drugs & Psychotropic
Substances Act 1985 & Rules; Drugs Price Control Order.
A brief study of the following Acts with special reference to the main provisions and the latest amendments:
Poisons Act 1919; Drugs and Magic Remedies (Objectionable Advertisements) Act 1954; Medical
Termination of Pregnancy Act 1970 & Rules 1975; Prevention of Cruelty to Animals Act 1960;
States Shops & Establishments Act & Rules; Insecticides Act 1968; AICTE Act 1987; Factories Act
1948; Minimum Wages Act 1948; Patents Act 1970.
A brief study of the various Prescription/Non-prescription Products. Medical/Surgical accessories,
diagnostic aids, appliances available in the market.
Introduction to dispensing and community pharmacy
Handling of prescription, source of errors in prescription, care required in dispensing procedures
including labeling of dispensed products. General dispensing procedures including labeling of
dispensed products; Pharmaceutical calculations: Posology, calculation of doses for infants,
adults and elderly patients; Enlarging and reducing recipes percentage solutions, alligation,
alcohol dilution, proof spirit, isotonic solutions, displacement value etc.
Principles involved and procedures adopted in dispensing of :
Typical prescriptions like mixtures, solutions, emulsions, creams, ointments, powders, capsules,
pastes, jellies, suppositories, ophthalmic, pastilles, lozenges, pills, lotions, liniments, inhalations,
Physical and chemical incompatibilities, inorganic incompatibilities including incompatibilities of
metals and their salts, non-metals, acids, alkalis, organic incompatibilities. Purine bases,
alkaloids, pyrazolone derivatives, amino acids, quaternary ammonium compounds, carbohydrates,
glycosides, anesthetics, dyes, surface active agents, correction of incompatibilities. Therapeutic
Organization and structure of retail and whole sale drug store-types of drug store and design,
legal requirements for establishment, maintenance and drug store-dispensing of proprietary
products, maintenance of records of retail and wholesale, patient counseling, role of pharmacist
in community health care and education (First aid, communicable diseases, nutrition, family
Organization and Structure of hospital pharmacy:
Organization of a hospital and hospital pharmacy, Responsibilities of a hospital pharmacist,
Pharmacy and therapeutic committee, Budget preparation and Implementation.
Contents, preparation and revision of hospital formulary.
Drug Store Management and Inventory Control:
Organization of drug store, Types of materials stocked, storage conditions; Purchase and
Inventory Control principles, purchase procedures, Purchase order, Procurement and stocking.
Out-patient dispensing, methods adopted; Dispensing of drugs to in-patients. Types of drug
distribution systems. Charging policy, labeling; Dispensing of drugs to ambulatory patients;
Dispensing of controlled drugs, Dispensing of ancillary supplies.
Central Sterile Supply Unit and their Management:
Types of materials for sterilization, Packing of materials prior to sterilization, sterilization
equipments, Supply of sterile materials.
Manufacture of Sterile and Non-sterile Products:
Policy making of manufacturable items, demand and costing, personnel requirements,
manufacturing practice, Master formula Card, production control, Manufacturing records.
Sources' of Information on drugs, disease, treatment schedules, procurement of information,
Computerized services (e.g., MEDLINE), Retrieval of information, Medication error- types of
medication errors, correction and reporting.
Prescription filling, drug profile, patient medication profile, cases on drug interaction and
adverse reactions, idiosyncratic cases. Pharmacoeconomics: Introduction to pharmacoeconomics,
different methods of pharmacoeconomics, application of pharmacoeconomics.
Pharmacoepidemiology: Definition and scope, method to conduct pharmacoepidemiological
studies, advantages & disadvantages of pharmacoepidemiological studies.
Methods of handling radioisotopes, radioisotope committee.
Importance of unit operations in manufacturing, Stoichiometry:
Material and energy balances, molecular units, mole fraction, tie substance, gas laws, mole
volume, primary and secondary quantities, equilibrium state, rate process, steady and unsteady
states, dimensionless equations, dimensionless formulae, dimensionless groups, different types of
graphic representation, mathematical problems.
Types of flow, Reynold's number, Viscosity, Concept of boundary layer, basic equations of fluid
flow, valves, flow meters, manometers and measurement of flow and pressure.
Concept of heat flow, applications of Fourier’s law, forced and natural convection, surface
coefficients, boiling liquids, condensing vapors, heat exchangers, heat interchangers, radiation,
black body, Stefan Boltzmann equation, Kirchoff’s law.
Basic concept of phase equilibria, factor affecting evaporation, evaporators, film evaporators,
single effect and multiple effect evaporators, Mathematical problems on evaporation.
Roult's law, phase diagrams, volatility; simple steam and flash distillations, principles of
rectification, Mc-Cabe Thiele method for calculations of number of theoretical plates, Azeotropic
Moisture content and mechanism of drying, rate of drying and time of drying calculations;
classification and types of dryers, dryers used in pharmaceutical industries and special drying
Definition, objectives of size reduction, mechanisms of size reduction, factors affecting size
reduction, laws governing energy and power requirements of a mills including ball mill, hammer
mill, fluid energy mill. Size separation: Different techniques of size separation, sieves, sieve
shakers, sedimentation tank, cyclone separators, bag fillers Etc.
Theory of mixing, solid-solid, solid-liquid and liquid-liquid mixing equipments.
Theory of filtration, continuous and batch filters, filter aids, filter media, industrial filters
including filter press, rotary filter, edge filter, Etc. Factors affecting filtration, filtration,
optimum cleaning cycle in batch filters. Principles of centrifugation, industrial centrifugal filters,
Characteristics of crystals like-purity, size, shape, geometry, habit, forms size and factors
affecting them, Solubility curves and calculation of yields. Material and heat balances around
Swenson Walker Crystallizer. Supersaturation, theory and its limitations, Nucleation mechanisms,
crystal growth.Study of various types of Crystallizers, tanks, agitated batch, Swenson Walker,
Single vacuum, circulating magma and Krystal Crystallizer, Caking of crystals and its prevention.
Basic concepts and definition, wet bulb and adiabatic saturation temperatures, Hygrometric chart
and measurement of humidity, application of humidity measurement in pharmacy, equipments for
Principle and applications of refrigeration and air conditioning;
General study of composition, corrosion, resistance, Properties and applications of the materials
of construction with special reference to stainless steel and glass.
Liquid handling - Different types of pumps, Gas handling-Various types of fans, blowers and
compressors, Solid handling-Bins, Bunkers, Conveyers, Air transport.
Classification, mechanism of corrosion, factors affecting, prevention and control.
Industrial Hazards and Safety Precautions:
Mechanical, Chemical, Electrical, fire and dust hazards. Industrial dermatitis, Accident records
Process variables, temperature, pressure, flow, level and vacuum and their measurements;
elements of automatic process control and introduction to automatic process control systems;
elements of computer aided manufacturing (CAM). Reactors and fundamentals of reactors design
Dosages Forms, designing & evaluation
Introduction, types of additives used in formulations, vehicles, stabilizers, preservatives,
suspending agents, emulsifying agents, solubilizers, colors, flavors and others, manufacturing
packaging, labeling, evaluation of clear liquids, suspensions and emulsions official in
Definitions, types, mechanisms of drug penetration, factors influencing penetration, semisolid
bases and their selection. General formulation of semisolids, clear gels manufacturing procedure,
Ideal requirements, bases, displacement value, manufacturing procedure, packaging and
Principle and method of extraction, preparation of infusion, tinctures, dry and soft liquid
Collection, processing and storage of whole human blood, concentrated human RBCs, dried
human plasma, human fibrinogen, human thrombin, human normal immunoglobulin, human
fibrin, foam plasma substitutes, -ideal requirements, PVP, dextran Etc. for control of blood
Definition, propellants, general formulation, manufacturing' and packaging methods,
Requirements, formulation, methods of preparation, labeling, containers, evaluation;
Cosmeticology and Cosmetic Preparations:
Fundamentals of cosmetic science, structure and functions of skin and hair. Formulation,
preparation and packaging of cosmetics for skin, hair, dentifrice and manicure preparations like
nail polish, nail polish remover, Lipsticks, eye lashes, baby care products Etc.
Advantages and disadvantages of capsule dosage form, material for production of hard gelatin
capsules, size of capsules, formulation, method of capsule filling, soft gelatin, capsule shell and
capsule content, importance of base absorption and minimum/gm factors in soft capsules, quality
control, stability testing and storage of capsule dosage forms.
Types of microcapsules, importance of microencapsulation in pharmacy, microencapsulation by
phase separation, coacervation, multi-orifice, spray drying, spray congealing, polymerization
complex emulsion, air suspension technique, coating pan and other techniques, evaluation of
Advantages and disadvantages of tablets, Application of different types of tablets, Formulation of
different types of tablets, granulation, technology on large-scale by various techniques, different
types of tablet compression machinery and the equipments employed, evaluation of tablets.
Coating of Tablets: Types of coating, film forming materials, formulation of coating solution,
equipments for coating, coating process, evaluation of coated tablets. Stabilityk inetics and
Pre-formulation factors, routes of administration, water for injection, and sterile water for
injection, pyrogenicity, non- aqueous vehicles, isotonicity and methods of its adjustment,
Formulation details, Containers and closures and selection, labeling; Pre-filling treatment,
washing of containers and closures, preparation of solution and suspensions, filling and closing of
ampoules, vials, infusion fluids, lyophilization & preparation of sterile powders, equipment for
large scale manufacture and evaluation of parenteral products; Aseptic Techniques-source of
contamination and methods of prevention, Design of aseptic area, Laminar flow bench services
and maintenance. Sterility testing of pharmaceuticals.
Definition, primary wound dressing, absorbents, surgical cotton, surgical gauzes etc., bandages,
adhesive tape, protective cellulosic hemostastics, official dressings, absorbable and non-
absorbable sutures, ligatures and catguts.
Packaging components, types, specifications and methods of evaluation, stability aspects of
packaging. Packaging equipments, factors influence choice of containers, legal and official
requirements for containers, package testing.
Pre-formulation studies, Study of physical properties of drug like physical form, particle size,
shape, density, wetting, dielectric constant. Solubility, dissolution and organoleptic properties
and their effect on formulation, stability and bioavailability. Study of chemical properties of
drugs like hydrolysis, oxidation, reduction, racemization, polymerization etc., and their influence
on formulation and stability of products. Study of pro-drugs in solving problems related to
stability, bioavailability and elegancy of formulations. Design, development and process
validation methods for pharmaceutical operations involved in the production of pharmaceutical
products with special reference to tablets, suspensions. Stabilization and stability testing
protocol for various pharmaceutical products.ICH Guidelines for stability testing of formulations.
In-vitro dissolution studies for solid dosage forms methods, interpretation of dissolution data.
Bioavailability studies and bioavailability testing protocol and procedures. In vivo methods of
evaluation and statistical treatment.GMP and quality assurance, Quality audit. Design,
development, production and evaluation of controlled/sustained/extended release formulations.
Biopharmaceutics & Pharmacokinetics
Passage of drugs across biological barrier (passive diffusion, active transport, facilitated diffusion,
ion-pair formation and pinocytosis); Factors influencing absorption- biological, physico-chemical,
physiological and pharmaceutical; Drug distribution in the body, plasma protein binding.
Significance of plasma drug concentration measurement. Compartment model- Definition and
Scope. Pharmacokinetics of drug absorption - Zero order and first order absorption rate constant
using Wagner-Nelson and residual methods. Volume of distribution and distribution coefficient.
Compartment kinetics- One compartment and two compartment models. Determination of
pharmacokinetic parameters from plasma and urine data after drug administration by
intravascular and oral route. Clearance concept, mechanism of renal clearance, clearance ratio,
determination of renal clearance. Extraction ratio, hepatic clearance, biliary excretion, extra-
hepatic circulation. Non-linear pharmacokinetics with special reference to one compartment
Definition and scope: Dosage adjustment in patients with and without renal and hepatic failure;
Design of single dose bio-equivalence study and relevant statistics; Pharmacokinetic drug
interactions and their significance in combination therapy.
Measures of bioavailability, Cmax, tmax, Keli and Area Under the Curve (AUC); Design of single
dose bioequivalence study and relevant statistics; Review of regulatory requirements for
conducting bioequivalent studies. Biopharmaceutical Classification System (BCS) of drugs.
Inorganic pharmaceutical & medicinal chemistry
Importance of inorganic compounds in pharmacy and medicine;
An outline of methods of preparation, uses, sources of impurities, tests for purity and identity,
including limit tests for iron, arsenic, lead, heavy metals, chloride, sulphate and special tests if
any, of the following classes of inorganic pharmaceuticals included in Indian Pharmacopoeia:
Acidifying agents, Antacids, Protectives and Adsorbents, Cathartics;
Major Intra- and Extra-cellular Electrolytes:
Physiological ions. Electrolytes used for replacement therapy, acid-base balance and combination
Transition elements and their compounds of pharmaceutical importance, Iron and haematinics,
mineral supplements; Cationic and anionic components of inorganic drugs useful for systemic
Protectives, Astringents and Anti-infectives.
Oxygen, Anesthetics (inorganic) and Respiratory stimulants;
Dentifrices, Anti-caries agents; Complexing and chelating agents used in therapy;
Sclerosing agents, Expectorants, Emetics, Inorganic poisons and antidotes.
Pharmaceutical Aids Used in Pharmaceutical Industry:
Anti-oxidants, Preservatives, Filter aids, Adsorbents, Diluents, Excipients, Suspending agents,
Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation,
stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of
Nuclear reaction, radioisotopes, radiopharmaceuticals, Nomenclature, Methods of obtaining their
standards and units of activity, half-life, measurement of activity, clinical applications, dosage,
Physical Chemistry and its importance in pharmacy
Importance of basic fundamentals of physical chemistry in pharmacy:
Behavior of Gases, Kinetic theory of gases, deviation from ideal behavior and explanation.
Physical properties (surface tension, parachor, viscosity, refractive index, dipole moment);
Ideal and real solutions, solutions of gases in liquids, colligative properties, partition coefficient,
conductance and its measurement, Debye Huckel theory;
First, Second and Third laws, Zeroth law, Concept of free energy, enthalpy and entropy, absolute
Thermochemical equations; Phase rule; Adsorption:
Freudlich and Gibbs adsorption, isotherms, Langmuir’s theory of adsorption.
Consequences of light absorption, Jabolenski diagram, Quantum efficiency;
Zero, First and Second order reactions, complex reactions, theories of reaction kinetics,
characteristics of homogeneous and heterogeneous catalysis, acid base and enzyme catalysis;
Postulates of quantum mechanics, operators in quantum mechanics, the Schrodinger wave
Organic Chemistry and its importance in pharmacy
Importance of fundamentals of organic chemistry in pharmaceutical sciences; Structure and Properties:
Atomic structure, Atomic orbitals, Molecular orbital theory, wave equation, Molecular orbitals,
Bonding and Anti-bonding orbitals, Covalent bond, Hybrid orbitals, Intramolecular forces, Bond
dissociation energy, Polarity of bonds, Polarity of molecules, Structure and physical properties,
Nomenclature, isomerism, stereoisomerism, conformational and configurational isomerism,
optical activity, specification of configuration, Reactions involving stereoisomers, chirality,
Stereoselective and stereospecific reactions; Structure, Nomenclature, Preparation and Reactions of:
Alkanes, Alkenes, Alkynes, Cyclic analogs, Dienes, Benzene, Polynuclear aromatic compounds,
Arenes, Alkyl halides, Alcohols, Ethers, Epoxides, Amines, Phenols, Aldehydes and ketones,
Carboxylic acids, Functional derivatives of' carboxylic acids, a,ß-Unsaturated carbonyl
compounds, Reactive intermediates- carbocations, carbanions, carbenes and nitrenes;
Nucleophilic and Electrophilic Aromatic Substitution Reactions:
Electrophilic and Nucleophilic Addition Reactions; Rearrangements
(Beckman, Hoffman, Benzilic acid, pinacole-pinacolone and Bayer-Villager).
Elimination reactions; Conservation of Orbital Symmetry and Rules:
Electrocyclic, Cycloaddition and Sigmatropic reactions;
Neighboring group effects; Catalysis by transition metal complexes; Heterocyclic Compounds:
Nomenclature, preparation, properties and reactions of 3, 4, 5, 6 & 7-membered heterocycles
with one or two heteroatoms like 0, N, S. Chemistry of lipids, Carbohydrates and Proteins.
Biochemistry in pharmaceutical sciences:
The concept of free energy, Determination of change in free energy - from equilibrium constant
and reduction potential, bioenergetics, production of ATP and its biological significance;
Nomenclature, enzyme kinetics and their mechanism of action, mechanism of inhibition, enzymes
Vitamins as co-enzymes and their significance. Metals as cofactors and their significance;
Carbohydrate Metabolism: Conversion of polysaccharides to glucose-1-phosphate, Glycolysis,
fermentation and their regulation, Gluconeogenesis and glycogenolysis, Metabolism of galactose
and galactosemia, Role of sugar nucleotides in biosynthesis, and Pentose phosphate pathway;
Significance, reactions and energetics of the cycle, Amphibolic role of the cycle, and Glyoxalic
Oxidation of fatty acids, ß-oxidation & energetics, biosynthesis of ketone bodies and their
utilization, biosynthesis of saturated and unsaturated fatty acids, Control of lipid metabolism,
Essential fatty acids & eicosanoids (prostaglandins, thromboxanes and leukotrienes),
phospholipids, and sphingolipids, Biosynthesis of eicosanoids, cholesterol, androgens,
progesterone, estrogens corticosteroids and bile acids.
Redox-potential, enzymes and co-enzymes involved in oxidation reduction & its control, The
respiratory chain, its role in energy capture and its control, energetics of oxidative
phosphorylation. Inhibitors of respiratory chain and oxidative phosphorylation, Mechanism of
Metabolism of ammonia and nitrogen containing monomers:
Nitrogen balance, Biosynthesis of amino acids, Catabolism of amino acids, Conversion of amino
acids to specialized products, Assimilation of ammonia, Urea cycle, metabolic disorders of urea
cycle, Metabolism of sulphur containing amino acids.
Pyrimidine biosynthesis and formation of deoxyribounucleotides.
Brief introduction of genetic organization of the mammalian genome, alteration and
rearrangements of genetic material, Biosynthesis of DNA and its replications.
Physical & chemical mutagenesis/carcinogenesis, DNA repair mechanism. Biosynthesis of RNA;
Genetic code, Components of protein synthesis and Inhibition of protein synthesis.
Physico-chemical and stereoisomeric (Optical, geometrical) aspects of drug molecules and
biological action, Bioisosterism, Drug-receptor interactions including transduction mechanisms;
Drug metabolism and Concept of Prodrugs; Principles of Drug Design (Theoretical Aspects):
Traditional analog and mechanism based approaches, QSAR approaches, Applications of quantum
mechanics, Computer Aided Drug Designing (CADD) and molecular modeling.
Synthetic Procedures, Mode of Action, Uses, Structure Activity Relationships including Physicochemical
Properties of the Following Classes of Drugs:
Drugs acting at synaptic and neuro-effector junction sites: Cholinergics, anti-cholinergics and
cholinesterase inhibitors, Adrenergic drugs, Antispasmodic and anti-ulcer drugs, Local
Anesthetics, Neuromuscular blocking agents.
Antihistamines, Eicosanoids, Analgesic-antipyretics, Anti-inflammatory (non-steroidal) agents.
Steroidal nomenclature (IUPAC) and stereochemistry, Androgens and anabolic agents, Estrogens
and Progestational agents, Oral contraceptives, Adrenocorticoids;
Drugs acting on the central nervous system:
General Anesthetics, Hypnotics and Sedatives, Anticonvulsants, Anti-Parkinsonian drugs,
Psychopharmacological agents (Neuroleptics, Anti-depressants, Anxiolytics), Opioid analgesics,
Anti-hypertensives, Anti-arrythmic agents, anti-anginal agents, Cardiotonics, Anti-hyperlipedemic
agents, Anticoagulants and Anti-platelet drugs.
Thyroid and Anti thyroid drugs; Insulin and oral hypoglycemic agents:
Chemotherapeutic Agents used in bacterial, fungal, viral, protozoal, parasitic and other
infections, Antibiotics: ß-Lactam, macrolides, tetracyclines, aminoglycosides, polypeptide
Anti-metabolites (including sulfonamides); Anti-neoplastic agents; Anti-viral agents (including anti–HIV);
Immunosuppressives and immunostimulants; Diagnostic agents; Pharmaceutical Aids.
Introduction, types of reactions mediated by micro-organisms, design of biotransformation
processes, selection of organisms, biotransformation process and its improvements with special
Techniques of immobilization, factors affecting enzyme kinetics, Study of enzymes such as
hyaluronidase, penicillinase, streptokinase, amylases and proteases, Immobilization of bacteria
Different techniques of pharmaceutical analysis, Preliminaries and definitions:
Significant figures, Rules for retaining significant digits, Types of errors, Mean deviation, Standard
deviation, Statistical treatment of small data sets, Selection of sample, Precision and accuracy.
Methods of expressing concentration, primary and secondary standards:
Acid base concepts, Role of solvents, Relative strengths of acids and bases, Ionization, Law of
mass action, Common ion effect, Ionic product of water, pH, Hydrolysis of salts, Henderson-
Hasselbach equation, Buffer solutions, Neutralization curves, Acid-base indicators, Theory of
indicators, Choice of indicators, Mixed indicators, Polyprotic systems, Polyamine and amino acid
Concepts of oxidation and reduction, Redox reactions, Strengths and equivalent weights of
oxidizing and reducing agents, Theory of redox titrations, Redox indicators, Cell representations,
Measurement of electrode potential, Oxidation-reduction curves, Iodimetry and Iodometry,
Titrations involving cerric ammonium sulphate, potassium iodate, potassium bromate, potassium
permanganate; titanous chloride, stannous chloride and Sodium 2,6-dichlorophenolindophenol.
Precipitation reactions, Solubility product, Effect of acids, temperature and solvent upon the
solubility of a precipitate, Argentometric titrations and titrations involving ammonium or
potassium thiocyanate, mercuric nitrate, and barium sulphate, indicators, Methods of end point
determination (GayLussac method, Mohr’s method, Volhard's method and Fajan's method).
Precipitation techniques, The colloidal state, Supersaturation, Co-precipitation, Post-
precipitation, Digestion, washing of the precipitate, Filtration, Filter papers and crucibles,
Ignition, Thermogravimetric curves, Specific examples like barium sulphate, aluminium as
aluminium oxide, calcium as calcium oxalate and magnesium as magnesium pyrophosphate,
Acidic and basic drugs, Solvents used, Indicators.
Complexing agents used as titrants, Indicators, Masking and demasking;
Diazotization titrations, Kjeldahl method of nitrogen estimation, Karl-Fischer aquametry, Oxygen
Extraction procedures including separation of drugs from excipients; Potentiometry:
Standard redox potential, Nernst equation, Half-cell potential, Standard and indicating
Specific and equivalent conductance, conductometric titrations.
Coulomb’s law, Coulometric titrations at fixed potential/current.
Decomposition potential, Half-wave potential, Diffision/migration/migration current, Ilkovic
equation, Cathodic/anodic polarography, Dropping mercury electrode, Graphite electrode,
Rotating platinum electrode, Amperometric titrations.
Theory of chromatography, plate theory, Factors affecting resolution, van Deemter equation. The
following chromatographic techniques (including instrumentation) with relevant examples of
Pharmacopoeial products: TLC, HPLC, GLC, HPTLC, Paper Chromatography and Column
The Theoretical Aspects, Basic Instrumentation, Elements of Interpretation of Spectra, and Applications
(quantitative and qualitative) of the Following Analytical Techniques:
Ultraviolet and visible spectrophotometry, Fluorimetry, Infrared spectrophotometry, Nuclear
Magnetic Resonance spectroscopy [proton technique only], Mass Spectrometry (EI & CI only),
Flame Photometry, Atomic Absorption Spectroscopy, X-ray Diffraction Analysis,
GLP, ISO 9000, TQM, Quality Review and Quality documentation, Regulatory control, regulatory
drug analysis, interpretation of analytical data, Validation, quality audit: quality of equipment,
validation of equipment, validation of analytical procedures.
Pathophysiology of common diseases; Basic Principles of Cell Injury and Adaptations:
Causes of Cellular injury, pathogenesis, morphology of cell injury, adaptations and cell death.
Basic Mechanisms involved in the process of inflammation and repair:
Vascular and cellular events of acute inflammation, chemical mediators of inflammation,
pathogenesis of chronic inflammation, brief outline of the process of repair.
T and B cells, MHC proteins, antigen presenting cells, immune tolerance, pathogenesis of
hypersensitivity reactions, autoimmune diseases, AIDS, Amyloidosis.
Asthma, diabetes, rheumatoid arthritis, gout, ulcerative colitis, neoplasia, psychosis, depression,
mania, epilepsy, acute and chronic renal failure, hypertension, angina, congestive heart failure,
atherosclerosis, myocardial infarction, congestive heart failure, peptic ulcer, anemias, hepatic
disorders, tuberculosis, urinary tract infections and sexually transmitted diseases. Wherever
applicable the molecular basis should be discussed.
Dosage forms and routes of administration, mechanism of action, combined effect of drugs,
factors modifying drug action, tolerance and dependence; Pharmacogenetics; Principles of Basic
and Clinical pharmacokinetics, absorption, Distribution, Metabolism and Excretion of drugs,
Adverse Drug Reactions; Bioassay of Drugs and Biological Standardization; Discovery and
development of new drugs, Bioavailability and bioequivalence studies;
Pharmacology of Peripheral Nervous System:
Neurohumoral transmission (autonomic and somatic), Parasympathomimetics,
Parasympatholytics, Sympathomimetics, Adrenergic receptor and neuron blocking agents,
Ganglion stimulants and blocking agents, Neuromuscular blocking Agents, Local anesthetic
Neurohumoral transmission in the C.N.S., General Anesthetics, Alcohols and disulfiram, Sedatives,
Hypnotics, Anti-anxiety agents and Centrally acting muscle relaxants, Psychopharmacological
agents (anti-psychotics), anti-maniacs, and hallucinogens, Antidepressants, Anti-epileptics drugs,
Anti-Parkinsonian drugs, Analgesics, Antipyretics, Narcotic analgesics and antagonists, C.N.S.
stimulants, Drug Addiction and Drug Abuse.
Drugs used in the management of congestive cardiac failure, Antihypertensive drugs, Anti-anginal
and Vasodilator drugs, including calcium channel blockers and beta adrenergic antagonists, Anti-
arrhythmic drugs, Anti-hyperlipedemic drugs, Drugs used in the therapy of shock.
Hematinics, Anticoagulants, Vitamin K and hemostatic agents, Fibrinolytic and anti-platelet
drugs, Blood and plasma volume expanders.
Fluid and electrolyte balance, Diuretics.
Histamine, Antihistaminic drugs, 5-HT- its agonists and antagonists, Prostaglandins, thromboxanes
and leukotrienes, Angiotensin, Bradykinin and Substance P and other vasoactive peptides, non-
steroidal anti-inflammatory and anti-gout agents.
Anti-asthmatic drugs including bronchodilators, Anti-tussives and expectorants, Respiratory
Drugs acting on the Gastrointestinal Tract:
Antacids, Anti-secretory and Anti-ulcer drugs, Laxatives and anti-diarrhoeal drugs, Appetite
Stimulants and Suppressants, Emetics and anti-emetics, Miscellaneous: Carminatives, demulcents,
protectives, adsorbents, astringents, digestants, enzymes and mucolytics.
Hypothalamic and pituitary hormones, Thyroid hormones and anti-thyroid drugs, parathormone,
calcitonin and Vitamin D, Insulin, glucagons, incretins, oral hypoglycemic agents and insulin
analogs, ACTH and corticosteroids, Androgens and anabolic steroids, Estrogens, progesterone and
oral contraceptives, Drugs acting on the uterus.
General Principles of Chemotherapy, Bacterial resistance; Sulfonamides and cotrimoxazole,
Antibiotics- Penicillins, Cephalosporins, Aminoglycosides, Chloramphenicol, Macrolides,
Tetracyclines, Quinolones, fluoroquinolones and Miscellaneous antibiotics; Chemotherapy of
tuberculosis, leprosy, fungal diseases, viral diseases, HIV and AIDS, urinary tract infections and
sexually transmitted diseases, malaria, amoebiasis and other protozoal infections and
Anthelmentics. Chemotherapy of malignancy and immunosuppressive agents.
Definition of poison, general principles of treatment of poisoning with particular reference to
barbiturates, opioids, organophosphorous and atropine poisoning, Heavy metals and heavy metal
Clinical Pharmacokinetics and individualization of Drug therapy, Drug delivery systems and their
Biopharmaceutic s & Therapeutic considerations, Drugs used during infancy and in the elderly
persons (Pediatrics & Geriatrics), Drugs used during pregnancy, Drug induced diseases, The basics
of drug interactions, General principles of clinical toxicology, Common clinical laboratory tests
Important Disorders of Organs, Systems and their Management:
Cardio-vascular disorders- Hypertension, Congestive heart failure, Angina, Acute myocardial
Epilepsy, Parkinsonism, Schizophrenia, Depression.
Peptic ulcer, Ulcerative colitis, Hepatitis, Cirrhosis.
Diabetes mellitus and Thyroid disorders.
Tuberculosis, Urinary tract infections, Enteric infections, Upper respiratory infections.
Rheumatic diseases, Gout and Hyperuricemia.
Acute Leukaemias, Hodgkin's disease. Therapeutic Drug Monitoring, Concept of Essential Drugs
Biological, marine, mineral and plant tissue cultures as sources of drugs;
Morphological, taxonomical, chemical and pharmacological classification of drugs;
Study of medicinally important plants belonging to the families with special reference to:
Apocynacae, Solanaceae, Rutaceae, Umbelliferae, Leguminosae, Rubiaceae, Liliaceae, Graminae,
Cultivation, Collection, Processing and Storage of Crude Drugs:
Factors influencing cultivation of medicinal plants, Types of soils and fertilizers of common use.
Pest management and natural pest control agents, Plant hormones and their applications,
Polyploidy, mutation and hybridization with reference to medicinal plants.
Adulteration of crude drugs and their detection by organoleptic, microscopic, physical, chemical
Introduction to Active Constituents of Drugs:
Their isolation, classification and properties.
Systematic pharmacognostic study of the followings:
agar, guar gum acacia, Honey, Isabagol, pectin, Starch, sterculia and Tragacanth.
Bees wax, Castor oil, Cocoa butter, Codliver oil, Hydnocarpus oil, Kokum butter, Lard, Linseed
oil, Rice Bran oil, Shark liver oil and Wool fat.
Study of Drugs Containing Resins and Resin Combinations like Colophony, podophyllum, jalap,
cannabis, capsicum, myrrh, asafoetida, balsam of Tolu, balsam of Peru, benzoin, turmeric,
Study of tannins and tannin containing drugs like Gambier, black catechu, gall and myrobalan.
General methods of obtaining volatile oils from plants, Study of volatile oils of Mentha,
Coriander, Cinnamon, Cassia, Lemon peel, Orange peel, Lemon grass, Citronella, Caraway, Dill,
Spearmint, Clove, Fennel, Nutmeg, Eucalyptus, Chenopodium, Cardamom, Valerian, Musk,
Preparation of extracts, Screening of alkaloids, saponins, cardenolides and bufadienolides,
flavonoids and leucoanthocyanidins, tannins and polyphenols, anthraquinones, cynogenetic
glycosides, amino acids in plant extracts.
Study of fibers used in pharmacy such as cotton, silk, wool, nylon, glass-wool, polyester and
Study of the biological sources, cultivation, collection, commercial varieties, chemical constituents,
substitutes, adulterants, uses, diagnostic macroscopic and microscopic features and specific chemical
tests of following groups of drugs.
Liquorice, ginseng, dioscorea, sarsaparilla, and senega.
Digitalis, squill, strophanthus and thevetia,
Psoralea, gentian, saffron, chirata, quassia.
Belladonna, hyoscyamus, datura, duboisia, coca and withania.
Ergot, rauwolfia, catharanthus, nux-vomica and physostigma.
Coffee, tea and cola. Biological sources, preparation, identification tests and uses of the
following enzymes: Diastase, papain, pepsin, trypsin, pancreatin.
Studies of Traditional Drugs:
Common vernacular names, botanical sources, morphology, chemical nature of chief constituents,
pharmacology, categories and common uses and marketed formulations of following indigenous
drugs: Amla, Kantkari, Satavari, Tylophora, Bhilawa, Kalijiri, Bach, Rasna, Punamava, Chitrack,
Apamarg, Gokhru, Shankhapushpi, Brahmi, Adusa, Atjuna, Ashoka, Methi, Lahsun, Palash, Guggal,
Gymnema, Shilajit, Nagarmotha and Neem. The holistic concept of drug administration in
traditional systems of medicine.Introduction to ayurvedic preparations like Arishtas, Asvas,
Gutikas, Tailas, Chumas, Lehyas and Bhasmas.
General Techniques of Biosynthetic Studies and Basic Metabolic Pathways/Biogenesis:
Brief introduction to biogenesis of secondary metabolites of pharmaceutical importance.
monoterpenes, sesquiterpenes, diterpenes, and triterpenoids.
a-carotenoids, ß-carotenes, vitamin A, Xanthophylls of medicinal importance.
Digitoxin, digoxin, hecogenin, sennosides, diosgenin and sarasapogenin.
Atropine and related compounds, Quinine, Reserpine, Morphine, Papaverine, Ephedrine, Ergot
Lignans, quassanoids and flavonoids. Role of plant-based drugs on National economy:
A brief account of plant based industries and institutions involved in work on medicinal and
aromatic plants in India. Utilization and production of phyto-constituents such as quinine, calcium
sennosides, podophyllotoxin, diosgenin, solasodine, and tropane alkaloids. Utilization of aromatic
plants and derived products with special reference to sandalwood oil, mentha oil, lemon grass oil,
vetiver oil, geranium oil and eucalyptus oil. World-wide trade in medicinal plants and derived
products with special reference to diosgenin (disocorea), taxol (Taxussps) digitalis, tropane
alkaloid containing plants, Papain, cinchona, Ipecac, Liquorice, Ginseng, Aloe, Valerian,
Rauwolfia and plants containing laxatives. Plant bitters and sweeteners.
Historical development of plant tissue culture, types of cultures, nutritional requirements,
growth and their maintenance. Applications of plant tissue culture in pharmacognosy.
Novel medicinal agents from marine sources.
Natural allergens and photosensitizing agents and fungal toxins. Herbs as health foods. Herbal cosmetics.
Standardization and quality control of herbal drugs, WHO guidelines for the standardization of herbal drugs.
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THE JOURNEY HOME by Selina I. Glater, M.A., R.M.T. For many of my young adult years I had no hope. In August of 1987, following my 30th birthday, the demons began to crowd in around me. I had just finished my Master's degree in musicology and was headed off to take a job in arts management in Dallas, Texas when the bottom fell out of my life raft. For years tremendous mood swings ravaged m