Cnpru.bsd.uchicago.edu

ANGER RESEARCH STUDIES
Social Information Processing: This study
Is anger a problem for you? Are you quick to act
is investigating how individuals with aggression on your anger? Is it creating trouble at home, at
The University of
work, or with friends? If so, you may have an
anger problem called Intermittent Explosive
interpreted. Subjects will be between 21-55, Disorder (IED) and may be eligible to take part in
our research studies.
requires 3-4 visits over 2-8 months (total time DEPARTMENT OF PSYCHIATRY
Anger Drug Study (Flu/Dep): In this study, we are
commitment about 10 hours). Principal testing men and women, ages 21 to 55 years old CLINICAL NEUROSCIENCE &
to see if Fluoxetine (Prozac) or Divalproex (Depakote) compared to placebo can reduce the BORDERLINE PERSONALITY DISORDER
PSYCHOPHARMACOLOGY
symptoms of Intermittent Explosive Disorder (IED). RESEARCH STUDIES
Do you feel like you’re on an emotional
RESEARCH UNIT
This study will require weekly visits for four months. rollercoaster? Have your relationships been
Principal Investigator: Emil Coccaro, M.D. stormy? Do you get angry and irritable
FMRI of the Anger Drug Study: In this study, we
frequently? If so, you may be suffering from
Borderline Personality Disorder and may be
are testing men and women, ages 21 to 55 years eligible to take part in our research studies.
old to see if Fluoxetine (Prozac), Divalproex (Depakote), or placebo (a sugar pill) can reduce the Benzodiazepine Study:
symptoms of IED. The imaging portion of this study is only open to people enrolled in the full Flu/Dep women ages 21-50 differ in their sensitivity to study. This study will require 2 sessions of up to 4 benzodiazepine drugs while in a brain scanner. hours each scheduled approximately 14 weeks This study will require 2 sessions, up to 4 apart. Principal Investigator: Emil Coccaro, M.D. hours each, scheduled approximately 1 week JOIN US IN OUR RESEARCH
Psychotherapy for Anger Study: In this study we
apart. If participants have never been involved are providing men and women, ages 18-55, 12 in a research study at the CNPRU previously, Director
session psychotherapy to see if two different types an additional 3-hour visit will be scheduled of anger management therapy can reduce the first for a diagnostic interview. Principal symptoms of Intermittent Explosive Disorder (IED) Associate Director
and impulsive, aggressive behavior. Participation in PERSONALITY DISORDER RESEARCH
this study will require 16 visits over approximately four months of time and 3 follow-up visits at Does your personality cause you problems?
three months, six months, and 12 months post- CNPRU Faculty
People with a personality disorder can have a
lifelong history of trouble with “moodiness,”
relationship problems, and impulsiveness. If this
sounds like you, you may have a personality
Vasopressin/Oxytocin Study: The objective of
disorder and maybe eligible to take part in our
this study is to validate the function of brain The University of Chicago
research studies.
vasopressin and oxytocin receptors in human aggression. Both of these drugs are FDA approved 5841 S. Maryland Avenue
Intranasal CRF: The purpose of this study is
Dept. of Psychiatry MC 3077
and being used to treat nighttime bed-wetting to increase our understanding of the role of Chicago, IL 60637
(vasopressin) and to stimulate labor or breast- corticotrophin releasing factor in human Phone: 773.834.6835
feeding (oxytocin). The study is recruiting men and behavior. We are specifically interested in the effects of these hormones on attention. This Fax: 773.834.4536
women, healthy and those with symptoms of IED, study involves a series of 4 visits over a one to ages 18-55, willing to participate in 5 visits over a 2- two month period for subjects between the month period. Principal Investigator: Royce Lee, ages of 21 and 55. Principal Investigator: HEALTHY VOLUNTEER STUDIES:
Genetics of Vulnerability to Antisocial
Behavior (Chicago Twin Study): If you are
If you are a healthy adult man or woman and
a twin between the ages of 18-55 years old, have no prior history of any psychiatric
and you and your twin sibling both live in the illness, neurological disorders, or problems
Chicago land area, you may be eligible to with drugs or alcohol, you may be eligible to
participate in a twin study. This study is take part in our research studies.
designed to see how certain behaviors run in twin pairs. The study requires a single visit Vasopressin/Oxytocin Study: The objective of
of six to eight hours. Principle Investigator: The Clinical Neuroscience and
this study is to validate the function of brain Psychopharmacology Research Unit
vasopressin and oxytocin receptors in human aggression. Both of these drugs are FDA approved and being used to treat nighttime bed-wetting (vasopressin) and to stimulate labor or breast-feeding Principle Investigators
(oxytocin). The study is recruiting men and women, healthy and those with symptoms of IED, ages 18-55, • Emil Coccaro, M.D.
willing to participate in 5 visits over a 2-month period. Director CNPRU & Professor of Psychiatry Principal Investigator: Royce Lee, M.D. Intranasal CRF: This study will test the effect of an
Neurobiology, lab measures, neuroimaging, intranasal challenge with CRH (Corticotrophin- and psychotherapy in aggression, impulsive Releasing Hormone) vs. Placebo on measures of &physiological causes of aggression, as emotional informational processing known to be • Royce Lee, M.D.
abnormal in depression. We are specifically interested in the effects of these hormones on attention. We will be testing men and women between the ages of 18-55 who are currently non- Primary research interests are the effects of depressed but have a lifetime history of depression early life trauma and the neurobiology of and those without any history of depression. The study requires a total of 4 visits over a 2-month • Michael McCloskey, PhD.
their time &participation. Transportation period. Principal Investigator: Royce Lee, M.D. Primary research interests are the etiology of Social Information Processing: This study is
aggression and psychotherapy and lab investigating how individuals with aggression Location: The CNPRU is located at the
measures for self- and other-directed problems differ from those without by comparing University of Chicago Wyler Children’s how social interactions are interpreted. Subjects • Kristen Jacobson, PhD.
Please contact us at:
will be between 21-55, and be healthy or have IED. The study requires 3-4 visits over 2-8 months (total time commitment about 10 hours). Associate Director of Twin Projects, CNPRU 773-834-6835
Principal Investigator: Emil Coccaro, M.D. Primary research interests are in genetics The Effect of Oxytocin on a Competitive
or you can email us at:
Computer Task : This study will test the effect of
a single dose of intranasal oxytocin vs. placebo on
self aggressive behavior. Subjects will be between 18-50 who are currently non-depressed but with a lifetime ** Some of the drugs being studied are not You can also visit us on the web at
history of depression. The study requires a total of FDA approved for the uses being studied*** two (2) visits over a 2 week period of time. http://psychiatry.uchicago.edu/cnpru
Principle Investigator: Royce Lee, M.D.

Source: http://cnpru.bsd.uchicago.edu/CNPRU_Brochure.pdf