Emergency Medicine Clerkship Handbook Created by:
Emergency Medicine Clerkship Seminar Series Objectives All seminars are small group, case based sessions, with an emphasis on interaction
1. Toxicology Describe the specific components of ABC’s as they refer to emergency
assessment. Take a goal directed history in order to identify the offending toxin, and quantifying the amount of toxin ingested and the tempo of symptom
progression Outline the common toxidromes (ASA, Acetominophen, TCA, Cocaine, Benzodiazepines) with the findings on physical exam . Basic treatment will
be outlined, but in not an objective Describe the indications for charcoal, multi-dose charcoal, gastric lavage,
and whole bowel irrigation Describe the role of the lab and “tox screens” in the assessment of poisoned patients. 2. X-Rays Develop and organized approach for interpretation of plain x-ray films. Extremity and chest films of common types of injuries will be the focus. Although treatment will be discussed, this is not the emphasis of the seminar 3. Mini ACLS Develop a differential diagnosis for life threatening causes of chest pain Discuss various ECG’s and the role of 15 lead ECG Describe the indications and contraindications for thrombolysis Discuss the ECG and rhythm strip characteristics and treatment of Ventricular Fibrillation
Canadian Triage and Acuity Scale (CTAS)
This can be found at the top corner of all charts in emerg – aside from their other uses,
you may find these triage designations useful in determining what type of patient presentation awaits you. Level I - Resuscitation Conditions that are threats to life or limb (or imminent risk of deterioration) requiring immediate aggressive interventions. Time to physician IMMEDIATE Usual presentations:
1. Code / Arrest 2. Major trauma 3. Shock states 4. Unconscious 5. Severe Respiratory Distress
Level II Emergent Conditions that are a potential threat to life, limb, or function, requiring rapid medical intervention. Time to physician assessment/interview < 15 min. Typical presentations include: altered LOC, head injury, severe trauma, chest pain, overdose, stroke, dyspnea, febrile neutropenia. Level III Urgent Conditions that could potentially progress to a serious problem, requiring emergency intervention. May be associated with significant discomfort or affecting ability to function at work or activities of daily living. Time to physician < 30 min. Presentations include: patients with moderate trauma (ex. fractures, dislocations), moderate asthma, vaginal bleeding, suicidal patients. Level IV Less Urgent (Semi urgent) Conditions that related to patient age, distress, or potential for deterioration or complications would benefit from intervention or reassurance within 1-2 hours. Time to physician < 1 hour Presentations include: minor head injuries, lacerations, ear ache, chronic low back pain, upper respiratory tract infections, depression. Level V Non Urgent Conditions that may be acute but non-urgent as well as conditions which may be part of a chronic problem with or without evidence of deterioration. The investigation or interventions for some of these illnesses or injuries could be delayed or even referred to other areas of the hospital or health care system. Time to physician < 2 hours. Presentations include abrasions, minor lacerations, sore throat, chronic mild abdominal pain. The Primary Survey Airway maintenance (w/ c-spine control) Breathing & Ventilation Circulation (pulses & hemorrhage control) Disability (neurological status) Exposure & Environment
Airway (with C-spine protection)
Assume a cervical spine injury in any pt with multi-system trauma, especially with an altered LOC or blunt injury above the clavicle.
In a conscious patient, the airway is most easily assessed by patient’s ability to speak to you.
Also note adventitious sounds, cyanosis, agitation, nasal flaring/indrawing in children.
1. decreased LOC 2. airway lumen: foreign body, vomit, secretions 3. airway wall: edema, fractures 4. extrinsic causes: trauma, mass, hematoma
Management: Basic vs. Definitive (intubation or surgical airway)
1. chin lift or jaw thrust 2. suction to clear oropharynx 3. nasopharyngeal or oropharyngeal airway
1. unable to protect airway 2. inadequate spontaneous ventilation 3. O2 saturation < 90% with 100% O2 4. profound shock 5. GCS < 9 6. anticipate in trauma, overdose, CHF, asthma, COPD 7. anticipate in transfer of critically ill patients
Breathing
Assessed by looking, listening, and feeling…
Look: anxiety / agitation, skin colour, chest movement, respiratory rate & effort Listen: stridor, wheezing, symmetry of air entry on auscultation Feel: tracheal shift, crepitus, flail segments, subcutaneous emphysema
o Typically 1-6 L/min, provides oxygen concentrations of 24-44%
o Allows for oxygen concentration of 40-60%
o Oxygen concentration >60% is possible
Circulation
control external bleeding: direct pressure, brachial/axillary/femoral pressure points
immediate surgical consultation for suspected internal bleeding
infusion of 1-2L RL or NS (14-16 gauge IV)
type-specific: often available w/in 10 minutes
o O negative used for children & women of child-bearing age o O positive for everyone else
Disability
Level of consciousness, the quick & dirty method: AVPU
o size & reactivity of pupils o movement of upper/lower extremities
GCS, the not so quick and dirty method -
reported in three parts: Eyes + Verbal + Motor = Total
note that, perhaps surprisingly, a dead person still scores 3/15 (there is no 0)
Verbal (5) Motor (6) Open spontaneously =
Incomprehensible sounds = 2 Decorticate / flexion = 3
Exposure / Environment
important to assess all areas of possible injury
keep patient warm with blanket, heaters to prevent hypothermia
Then What?
The rapid primary survey is often done simultaneously with resuscitation, followed by
the more detailed secondary survey, and any definitive care.
Allegies Medications Past Medical History Last Meal Events related to injury
Head & Neck: pupils, LOC, facial bones, tympanic membranes Chest: breath sounds, flail segment, subcutaneous emphysema Abdomen: bowel sounds, distention, tenderness, etc. MSK: include log roll, palpation of T and L spine Neurological Exam: GCS, cranial nerves, focal deficits, papilledema
An Approach to Chest Pain
Differential Diagnosis for Chest Pain Musculoskeletal Cardiac Pulmonary
Life-Threatening Causes of Chest Pain – consider these first:
- unstable angina / acute MI - thoracic aortic dissection - pulmonary embolism - spontaneous pneumothorax / tension pneumothorax - esophageal rupture - cardiac tamponade
o Position of Pain o Quality of Pain o Radiation: to arm, neck, jaw, back o Severity o Timing: including onset, as well as aggravating & alleviating factors
- Classic pain of Coronary Artery Disease:
o Retrosternal pressure/heaviness o Radiating to arm/neck/jaw o Often with SOB, Nausea, Diaphoresis
- Be aware of atypical presentations in:
o Patients with diabetes o Elderly patients o Women
o Smoking o Diabetes o HTN o Hyperlipidemia o Personal hx of CAD o Family hx of CAD
Physical Exam
- Vitals, including BP in both arms - Palpate chest wall for tenderness (although a positive finding does not rule out MI, as
25% of patients with an MI have tenderness)
Investigations
o In London currently: CK, Myoglobin, Troponin o Be aware that “routine cardiac markers” vary from city to city
Localization of MI based on ECG findings ST Changes Likely Infarct Location
Right Ventricular (often associated with Inferior)
Treatment
- Commonly used medications in MI management:
o ASA 160-325mg o Oxygen o B-Blockers o Nitroglycerine o Morphine o Heparin or Low Molecular Weight Heparin (ex Enoxaparin) o Thrombolytics: ex. TPA, TNK, Streptokinase
- Symptoms consistent with MI, onset within 12 hours, and - > 1mm ST elevation in 2 or more contiguous limb leads, or - >2mm ST elevation in 2 or more contiguous chest leads, or - new LBBB
Thrombolysis – Absolute Contraindications
- Active internal bleeding - History of CVA < 6 months, or any hemorrhagic CVA - Intracranial or intraspinous surgery or trauma < 2 months - Intracranial or intraspinous neoplasm or AVM - Suspected aortic dissection or pericarditis
Thrombolysis – Relative Contraindications
- Severe HTN (systolic > 200 or diastolic > 120) - Active PUD - Pregnancy - Puncture of noncompressible vessel - Significant chest trauma from CPR - Bleeding diathesis
Trauma – A Brief Overview
Usually divided into blunt (ex. MVA, fall, sports injury) vs. penetrating (gunshot, stabbing).
Always ask about head injury, loss of consciousness, amnesia, headache, vomiting, seizure activity.
Chest Trauma Life threatening chest injuries
Potentially Life-Threatening Chest Injuries
Contusion: pulmonary or myocardial Hernia: traumatic diaphragmatic Esophageal Perforation Traumatic aortic injury / tracheobronchial disruption
Abdominal Trauma
Blunt trauma: more common; typically leads to solid organ injury Penetrating trauma: often causes hol ow organ injury Physical Exam
Note that it is important to have a high clinical suspicion for abd injury in trauma, even in the absence of any immediate physical findings.
- X-Ray: free air under diaphragm, diaphragmatic herniation -
FAST (focused abdominal sonogram for trauma) Ultrasound
o Looking for free fluid in peritoneal cavity
Direct Injury Possible Associated Injuries
Duodenum, Pancreas, Small bowel mesentery
Genitourinary trauma
History:
Renal: blunt (contusions, hematomas) vs penetrating Management
o if hemodynamically unstable o all penetrating wounds o renal pedicle injury
rarely due to blunt or penetrating trauma
extraperitoneal: typically rupture due to pelvic fracture fragments
o often needs only Foley drainage unless major rupture
intraperitoneal: rupture from trauma in patient with full bladder
Contraindications to foley catheterization:
high riding prostate on DRE in male patients
C-Spine Injuries
Assessment of a Suspected C-spine injury
o Midline neck pain o Numbness, paresthesias o Loss of consciousness
o Altered mental state o Neck tenderness o Neurologic deficits
o AP o Lateral C1-T1 (+ swimmer’s view if needed) o Odontoid
What to look for on the lateral films? (ABCS)
Alignment
o must see C1 to C7/T1 junction o assess 5 lines of contour
anterior vertebral line posterior vertebral line posterior border of facets laminar fusion line posterior spinous line
o including height, width, shape of vertebral bodies
Cartilage Soft Tissues
o widening of retropharyngeal or retrotracheal spaces
Defined as inadequate end-organ perfusion; ie inadequate transport of oxygen to organs and tissues. Classified in various different ways, including SHOCK:
o Septic & Spinal shock o Hemorrhagic / Hypovolemic shock o Obstructive shock (ex. tension pneumothorax, cardiac tamponade) o Cardiogenic shock (ex. MI) o AnaphylaKtic (so it’s not a perfect mnemonic)
In a trauma patient, assume shock is hemorrhagic unless proven otherwise. Early: o Incr. HR o Incr. RR o Narrow pulse pressure o Decr. Urine output o Prolonged Cap Refill o Pale, cool extremities Late: o Hypotension o Altered LOC Replacemen Class <15%
All patients in whom shock is suspected need:
control external bleeding: direct pressure, brachial/axillary/femoral pressure points
immediate surgical consultation for suspected internal bleeding
infusion of 1-2L RL or NS (14-16 gauge IV)
Toxicology – General Principles
ABCs of Toxicology Airway Breathing Circulation Drugs: ACLS if needed for resuscitation, universal antidotes Draw Blood Decontamination: if possible to decrease absorption or increase elimination Expose / Examine Full vitals, Foley, monitors Give specific antidotes, treatments
Universal Antidotes
These include the following interventions with little chance of harm, but the potential for significant benefit:
a necessary cofactor for glucose metabolism
may be given to any pt presenting with altered LOC, though many will check chemstrip glucose at the bedside before administering
Administration of naloxone may be diagnostic as well as therapeutic
Adults: 2mg initial bolus IV/IM/SC/ETT (in suspected chronic opioid users, some recommend 0.1-0.4mg every 2 minutes to prevent sudden acute withdrawal)
Children: 0.01mg/kg initial bolus IV/IO/ETT
may need maintenance dose, as narcotics typically have longer half life than naloxone
Decontamination
Skin - removal of contaminated clothing, flushing of eyes, etc.
o prevents absorption of many drugs/toxins, with the exception of acids,
o 500ml (child) to 2000ml (adult) of balanced electrolyte solution by mouth o indications
awake, alert patient with recent ingestion (4-6 hours) drug/toxin not bound to charcoal drug packages (body packers)
suspected ileus, perforation, obstruction
Essential Bloodwork
Differential Dx for Metabolic Acidosis with increased anion gap (MUDPILES CAT)
Methanol Paraldehyde Iron / Isoniazid Ethylene glycol Salicylates
Osmolar gap = Measured Osm. – Calculated Osm.
Calculated Osm. Gap = 2Na + BUN + Glucose (mmol/L)
Normal Osmolar Gap < 10mOsm/L Differential Dx for increased osmolar gap
Methanol, Ethanol, Ethylene Glycol, Isopropyl Alcohol
Some Common Toxidromes Toxidrome Typical agents Other findings Specific findings interventions Sympathomimet Cocaine Cholinergic Anticholinergic Salicylates Benzodiazepines Ativan Serotonin syndrome
used as an “antidote” for benzodiazepine overdose
useful, in theory, as it may reduce the need for intubation in benzodiazepine overdose
but, increases risk of seizure, specifically in cases of TCA co-ingestion or pre-existing seizure disorder
also, most patients with a benzodiazepine overdose do well with supportive care
many therefore limit the use of flumazenil to reversal of therapeutic benzodiazepine sedation in controlled settings
Evaluation
Please complete at the end of your rotation and return to the Emergency Medicine office at South Street, Room C21
1. The material in this booklet enhanced my ability to participate in the Emergency
2. The material in this booklet was relevant and useful to me during my clerkship
3. I anticipate that the material in this booklet will be useful to me during my future
training – ex.during 4th year electives, residency, etc.
(Please comment on sections you found particularly helpful, areas in which you’d like
more information, and any additional web resources you think others would find useful.) ______________________________________________________________________________
______________________________________________________________________________
______________________________________________________________________________
______________________________________________________________________________
______________________________________________________________________________
______________________________________________________________________________
NINDS GENSAT BAC TRANSGENIC PROJECT Supported by NINDS Contract # N01-NS-7-2370 The Rockefeller University 1. BAC Transgene Construction Shiaoching Gong The plasmid, pLD53.SC2, used to generate EGFP lines is a derivative of pLD53. PLD53 was digested with BamHI and SacI to get rid of the tetAR and oriT origin and it was replaced by a NotI-SalI-SpeI adaptor. A 1.1 kb EGFP-P
Malaria update 2012 Gunnar Holmgren, Infectious diseases clinic, Ryhov Hospital, Jönköping, Sweden May 2012 About 3.3 billion people are at risk of malaria globally, 350 million have the parasite in their body and 250 million will be ill with malaria in 2011 with almost 1 million dying as a result. Some new research suggests that 1.24 million died of malaria in 2010 with 85% of the dea