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Profyoshikawabook
1. Zen K, Yasui K, Nakajima T, Zen Y, Zen K, Gen Y, Mitsuyoshi H, Minami
M, Mitsufuji S, Tanaka S, Itoh Y, Nakanuma Y, Taniwaki M, Arii S, Okanoue T,
Yoshikawa T. ERK5 is a target for gene amplification at 17p11 and promotes cell
growth in hepatocellular carcinoma by regulating mitotic entry. Genes
2. Taniguchi H, Sakagami J, Suzuki N, Hasegawa H, Shinoda M, Tosa M,
Baba T, Yasuda H, Kataoka K, Yoshikawa T. Adenoendocrine cell carcinoma of the
gallbladder clinically mimicking squamous cell carcinoma. Int J Clin Oncol
3. Takano H, Inoue KI, Shimada A, Sato H, Yanagisawa R, Yoshikawa T.
Urinary trypsin inhibitor protects against liver injury and coagulation pathway
dysregulation induced by lipopolysaccharide/D-galactosamine in mice. Lab Invest
4. Takagi T, Naito Y, Inoue M, Akagiri S, Mizushima K, Handa O, Kokura S,
Ichikawa H, Yoshikawa T. Inhalation of carbon monoxide ameliorates
collagen-induced arthritis in mice and regulates the articular expression of IL-1beta
and MCP-1. Inflammation 2009;32:83-8.
5. Piga R, Naito Y, Kokura S, Handa O, Yoshikawa T. Inhibitory effect of
serotonin derivatives on high glucose-induced adhesion and migration of monocytes
on human aortic endothelial cells. Br J Nutr 2009:1-9.
6. Omatsu T, Naito Y, Handa O, Hayashi N, Mizushima K, Qin Y, Hirata I,
Adachi S, Okayama T, Kishimoto E, Takagi T, Kokura S, Ichikawa H, Yoshikawa T.
Involvement of reactive oxygen species in indomethacin-induced apoptosis of small
intestinal epithelial cells. J Gastroenterol 2009;44 Suppl 19:30-4.
7. Okayama T, Yoshida N, Uchiyama K, Takagi T, Ichikawa H, Yoshikawa T.
Mast cells are involved in the pathogenesis of indomethacin-induced rat enteritis. J
Gastroenterol 2009;44 Suppl 19:35-9.
8. Okayama T, Kokura S, Ishikawa T, Adachi S, Hattori T, Takagi T, Handa
O, Naito Y, Yoshikawa T. Antitumor effect of pretreatment for colon cancer cells
with hyperthermia plus geranylgeranylacetone in experimental metastasis models
and a subcutaneous tumor model of colon cancer in mice. Int J Hyperthermia
9. Nomura K, Fujimoto Y, Yamashita M, Morimoto Y, Ohshiro M, Sato K,
Oyake T, Kowata S, Konishi H, Yoshikawa T, Ishida Y, Taniwaki M. Absence of
pseudomembranes in Clostridium difficile-associated diarrhea in patients using
immunosuppression agents. Scand J Gastroenterol 2009;44:74-8.
10. Nin M, Katoh N, Kokura S, Handa O, Yoshikawa T, Kishimoto S.
Dichotomous effect of ultraviolet B on the expression of corneodesmosomal
enzymes in human epidermal keratinocytes. J Dermatol Sci 2009;54:17-24.
11. Naito Y, Yoshikawa T. Oxidative Stress-Induced Posttranslational
Modification of Proteins as a Target of Functional Food. Forum Nutr
12. Mitsuyoshi H, Yasui K, Harano Y, Endo M, Tsuji K, Minami M, Itoh Y,
Okanoue T, Yoshikawa T. Analysis of hepatic genes involved in the metabolism of
fatty acids and iron in nonalcoholic fatty liver disease. Hepatol Res 2009;39:366-73.
13. Hirata I, Naito Y, Handa O, Hayashi N, Mizushima K, Adachi S, Omatsu
T, Okayama T, Kishimoto E, Ichikawa H, Takagi T, Kokura S, Otaka M, Yoshikawa
T. Heat-Shock Protein 70-Overexpressing Gastric Epithelial Cells Are Resistant to
Indomethacin-Induced Apoptosis. Digestion 2009;79:243-250.
14. Gen Y, Yasui K, Zen K, Nakajima T, Tsuji K, Endo M, Mitsuyoshi H,
Minami M, Itoh Y, Tanaka S, Taniwaki M, Arii S, Okanoue T, Yoshikawa T. A novel
amplification target, ARHGAP5, promotes cell spreading and migration by
negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells. Cancer Lett
15. Adachi S, Kokura S, Okayama T, Ishikawa T, Takagi T, Handa O, Naito Y,
Yoshikawa T. Effect of hyperthermia combined with gemcitabine on apoptotic cell
death in cultured human pancreatic cancer cell lines. Int J Hyperthermia
16. Tsubouchi Y, Fukuda W, Kawahito Y, Kohno M, Wada M, Ishino H,
Hamaguchi M, Yamamoto A, Kadoya M, Niimi M, Yoshikawa T. A case of lupus
nephritis improved after appropriately adjusting the dosage of mizoribine. Mod
17. Suzuki T, Yoshida N, Nakabe N, Isozaki Y, Kajikawa H, Takagi T, Handa
O, Kokura S, Ichikawa H, Naito Y, Matsui H, Yoshikawa T. Prophylactic effect of
rebamipide on aspirin-induced gastric lesions and disruption of tight junctional
protein zonula occludens-1 distribution. J Pharmacol Sci 2008;106:469-77.
18. Soga K, Yamauchi J, Kawai Y, Yamada M, Uchikawa R, Tegoshi T,
Mitsufuji S, Yoshikawa T, Arizono N. Alteration of the expression profiles of acidic
mucin, sialytransferase, and sulfotransferases in the intestinal epithelium of rats
infected with the nematode Nippostrongylus brasiliensis. Parasitol Res
19. Soga K, Tomikashi K, Miyawaki KI, Okuda K, Sugiyama Y, Sekikawa S,
Wakabayashi N, Konishi H, Mitsufuji S, Kataoka K, Yoshikawa T. Endoscopic
Injection Sclerotherapy with Ethanolamine Oleate with Iopamidol for
Esophagojejunal Varices in Idiopathic Portal Hypertension. Dig Dis Sci 2008.
20. Okuda T, Yoshida N, Takagi T, Handa O, Kokura S, Ichikawa H, Naito Y,
Yoshikawa T. CV-11974, angiotensin II type I receptor antagonist, reduces the
severity of indomethacin-induced rat enteritis. Dig Dis Sci 2008;53:657-63.
21. Nomura K, Fujimoto Y, Yamashita M, Morimoto Y, Ohshiro M, Sato K,
Oyake T, Kowata S, Konishi H, Yoshikawa T, Ishida Y, Taniwaki M. Absence of
pseudomembranes in Clostridium difficile-associated diarrhea in patients using
immunosuppression agents. Scand J Gastroenterol 2008:1-5.
22. Naito Y, Iinuma S, Yagi N, Boku Y, Imamoto E, Takagi T, Handa O,
Kokura S, Yoshikawa T. Prevention of Indomethacin-Induced Gastric Mucosal
Injury in Helicobacter pylori-Negative Healthy Volunteers: A Comparison Study
Rebamipide vs Famotidine. J Clin Biochem Nutr 2008;43:34-40.
23. Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Fukuda K, Kin S,
Nakase Y, Shimomura K, Oue N, Yasui W, Hayasizaki H, Okazaki Y, Yamagishi H,
Hagiwara A, Otsuji E. Overexpression of RegIV in peritoneal dissemination of
gastric cancer and its potential as A novel marker for the detection of peritoneal
micrometastasis. Anticancer Res 2008;28:1169-79.
24. Manabe E, Handa O, Naito Y, Mizushima K, Akagiri S, Adachi S, Takagi
T, Kokura S, Maoka T, Yoshikawa T. Astaxanthin protects mesangial cells from
hyperglycemia-induced oxidative signaling. J Cell Biochem 2008;103:1925-37.
25. Kawata E, Ashihara E, Kimura S, Takenaka K, Sato K, Tanaka R, Yokota
A, Kamitsuji Y, Takeuchi M, Kuroda J, Tanaka F, Yoshikawa T, Maekawa T.
Administration of PLK-1 small interfering RNA with atelocollagen prevents the
growth of liver metastases of lung cancer. Mol Cancer Ther 2008;7:2904-12.
26. Kawahito Y, Ichinose S, Sano H, Tsubouchi Y, Kohno M, Yoshikawa T,
Tokunaga D, Hojo T, Harasawa R, Nakano T, Matsuda K. Mycoplasma fermentans
glycolipid-antigen as a pathogen of rheumatoid arthritis. Biochem Biophys Res
27. Katada K, Yoshida N, Suzuki T, Okuda T, Mizushima K, Takagi T,
Ichikawa H, Naito Y, Cepinskas G, Yoshikawa T. Dextran sulfate sodium-induced
acute colonic inflammation in angiotensin II type 1a receptor deficient mice.
28. Kamitsuji Y, Kuroda J, Kimura S, Toyokuni S, Watanabe K, Ashihara E,
Tanaka H, Yui Y, Watanabe M, Matsubara H, Mizushima Y, Hiraumi Y, Kawata E,
Yoshikawa T, Maekawa T, Nakahata T, Adachi S. The Bcr-Abl kinase inhibitor
INNO-406 induces autophagy and different modes of cell death execution in
Bcr-Abl-positive leukemias. Cell Death Differ 2008;15:1712-1722.
29. Ito R, Kita M, Shin-Ya M, Kishida T, Urano A, Takada R, Sakagami J,
Imanishi J, Iwakura Y, Okanoue T, Yoshikawa T, Kataoka K, Mazda O. Involvement
of IL-17A in the pathogenesis of DSS-induced colitis in mice. Biochem Biophys
30. Ishino H, Kawahito Y, Tsubouchi Y, Kohno M, Wada M, Yamamoto A,
Hamaguchi M, Kadoya M, Tokunaga D, Hojo T, Matsuyama M, Yoshimura R,
Yoshikawa T. Feedback Control of the Arachidonate Cascade in Osteoblastic Cells
by 15-deoxy-Delta-Prostaglandin J(2). J Clin Biochem Nutr 2008;42:64-9.
31. Hosoda H, Fukui M, Nakayama I, Asano M, Kadono M, Hasegawa G,
Yoshikawa T, Nakamura N. Bone mass and bone resorption in postmenopausal
women with type 2 diabetes mellitus. Metabolism 2008;57:940-5.
32. Hasegawa G, Kajiyama S, Tanaka T, Imai S, Kozai H, Fujinami A, Ohta
M, Obayashi H, Park H, Nakano K, Tanaka M, Shiraishi E, Fukui M, Yoshikawa T,
Nakamura N. The alpha-glucosidase inhibitor acarbose reduces the net
electronegative charge of low-density lipoprotein in patients with newly diagnosed
type 2 diabetes. Clin Chim Acta 2008;390:110-4.
33. Hamaguchi M, Kawahito Y, Omoto A, Tsubouchi Y, Kohno M, Seno T,
Kadoya M, Yamamoto A, Ishino H, Matsuyama M, Yoshimura R, Yoshikawa T.
Eicosapentaenoic Acid suppresses the proliferation of synoviocytes from
rheumatoid arthritis. J Clin Biochem Nutr 2008;43:126-8.
34. Fukui M, Tanaka M, Shiraishi E, Harusato I, Hosoda H, Asano M,
Kadono M, Hasegawa G, Yoshikawa T, Nakamura N. Serum uric acid is associated
with microalbuminuria and subclinical atherosclerosis in men with type 2 diabetes
35. Fukui M, Tanaka M, Kadono M, Imai S, Hasegawa G, Yoshikawa T,
Nakamura N. Serum prostate-specific antigen levels in men with type 2 diabetes.
36. Fukui M, Tanaka M, Hasegawa G, Yoshikawa T, Nakamura N.
Association between serum bioavailable testosterone concentration and the ratio of
glycated albumin to glycated hemoglobin in men with type 2 diabetes. Diabetes
37. Fukui M, Kitagawa Y, Kamiuchi K, Hasegawa G, Yoshikawa T,
Nakamura N. Association between serum estradiol concentrations and carotid
atherosclerosis in men with type 2 diabetes mellitus. Metabolism 2008;57:285-9.
38. Fukase K, Kato M, Kikuchi S, Inoue K, Uemura N, Okamoto S, Terao S,
Amagai K, Hayashi S, Asaka M. Effect of eradication of Helicobacter pylori on
incidence of metachronous gastric carcinoma after endoscopic resection of early
gastric cancer: an open-label, randomised controlled trial. Lancet 2008;372:392-7.
39. Aoi W, Naito Y, Takanami Y, Ishii T, Kawai Y, Akagiri S, Kato Y, Osawa T,
Yoshikawa T. Astaxanthin improves muscle lipid metabolism in exercise via
inhibitory effect of oxidative CPT I modification. Biochem Biophys Res Commun
40. Ando T, Ishikawa T, Kokura S, Naito Y, Yoshida N, Yoshikawa T.
Endoscopic analysis of gastric ulcer after one week's treatment with omeprazole and
rabeprazole in relation to CYP2C19 genotype. Dig Dis Sci 2008;53:933-7.
41. Akagiri S, Naito Y, Ichikawa H, Mizushima K, Takagi T, Handa O,
Kokura S, Yoshikawa T. A Mouse Model of Metabolic Syndrome; Increase in
Visceral Adipose Tissue Precedes the Development of Fatty Liver and Insulin
Resistance in High-Fat Diet-Fed Male KK/Ta Mice. J Clin Biochem Nutr
42. Akagiri S, Naito Y, Ichikawa H, Mizushima K, Takagi T, Handa O,
Kokura S, Yoshikawa T. Bofutsushosan, an Oriental Herbal Medicine, Attenuates
the Weight Gain of White Adipose Tissue and the Increased Size of Adipocytes
Associated with the Increase in Their Expression of Uncoupling Protein 1 in
High-Fat Diet-Fed Male KK/Ta mice. J Clin Biochem Nutr 2008;42:158-66.
43. Akabame S, Hamaguchi M, Tomiyasu K, Tanaka M, Kobayashi-Takenaka
Y, Nakano K, Oda Y, Yoshikawa T. Evaluation of vulnerable coronary plaques and
non-alcoholic fatty liver disease (NAFLD) by 64-detector multislice computed
tomography (MSCT). Circ J 2008;72:618-25.
44. Yuba T, Nagata K, Yamada T, Osugi S, Kuwahara H, Iwasaki Y, Handa O,
Naito Y, Fushiki S, Yoshikawa T, Marunaka Y. A novel potent inhibitor of inducible
nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice. Respir
45. Yoshida N, Katada K, Handa O, Takagi T, Kokura S, Naito Y, Mukaida N,
Soma T, Shimada Y, Yoshikawa T, Okanoue T. Interleukin-8 production via
protease-activated receptor 2 in human esophageal epithelial cells. Int J Mol Med
46. Wada M, Kawahito Y, Kimura S, Kohno M, Ishino H, Kimura M, Omoto
A, Yamamoto A, Hamaguchi M, Tsubouchi Y, Tokunaga D, Hojo T, Ashihara E,
Maekawa T, Yoshikawa T. siRNA targeting PLK-1 induces apoptosis of
synoviocytes in rheumatoid arthritis. Biochem Biophys Res Commun
47. Tsuboi H, Naito Y, Katada K, Takagi T, Handa O, Kokura S, Ichikawa H,
Yoshida N, Tsukada M, Yoshikawa T. Role of the thrombin/protease-activated
receptor 1 pathway in intestinal ischemia-reperfusion injury in rats. Am J Physiol
Gastrointest Liver Physiol 2007;292:G678-83.
48. Sakakura C, Miyagawa K, Fukuda KI, Nakashima S, Yoshikawa T, Kin S,
Nakase Y, Ida H, Yazumi S, Yamagishi H, Okanoue T, Chiba T, Ito K, Hagiwara A,
Ito Y. Frequent silencing of RUNX3 in esophageal squamous cell carcinomas is
associated with radioresistance and poor prognosis. Oncogene 2007;26:5927-38.
49. Piga R, Naito Y, Kokura S, Handa O, Yoshikawa T. Short-term high
glucose exposure induces monocyte-endothelial cells adhesion and transmigration
by increasing VCAM-1 and MCP-1 expression in human aortic endothelial cells.
50. Okuda T, Yoshida N, Takagi T, Handa O, Kokura S, Ichikawa H, Naito Y,
Yoshikawa T. CV-11974, angiotensin II type I receptor antagonist, reduces the
severity of indomethacin-induced rat enteritis. Dig Dis Sci 2007.
51. Nakashima S, Nakamura T, Miyagawa K, Yoshikawa T, Kin S, Kuriu Y,
Nakase Y, Sakakura C, Otsuji E, Hagiwara A, Yamagishi H. In situ tissue
engineering of the bile duct using polypropylene mesh-collagen tubes. Int J Artif
52. Nakase Y, Nakamura T, Kin S, Nakashima S, Yoshikawa T, Kuriu Y,
Miyagawa K, Sakakura C, Otsuji E, Ikada Y, Yamagishi H, Hagiwara A. Endocrine
cell and nerve regeneration in autologous in situ tissue-engineered small intestine. J
53. Nakabe N, Kokura S, Shimozawa M, Katada K, Sakamoto N, Ishikawa T,
Handa O, Takagi T, Naito Y, Yoshida N, Yoshikawa T. Hyperthermia attenuates
TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human
arterial endothelial cells. Int J Hyperthermia 2007;23:217-24.
54. Naito Y, Takagi T, Yoshikawa T. Molecular fingerprints of
neutrophil-dependent oxidative stress in inflammatory bowel disease. J
55. Manabe E, Handa O, Naito Y, Mizushima K, Akagiri S, Adachi S, Takagi
T, Kokura S, Maoka T, Yoshikawa T. Astaxanthin protects mesangial cells from
hyperglycemia-induced oxidative signaling. J Cell Biochem 2007.
56. Kokura S, Yoshida N, Okuda T, Nakabe N, Sakamoto N, Isozaki Y,
Hattori T, Handa O, Takagi T, Naito Y, Yoshikawa T. Hyperthermia ameliorates
2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: the role of heat shock
proteins. Int J Hyperthermia 2007;23:17-28.
57. Kokura S, Adachi S, Manabe E, Mizushima K, Hattori T, Okuda T,
Nakabe N, Handa O, Takagi T, Naito Y, Yoshida N, Yoshikawa T. Whole body
hyperthermia improves obesity-induced insulin resistance in diabetic mice. Int J
58. Kobayashi Y, Kamitsuji Y, Kuroda J, Tsunoda S, Uoshima N, Kimura S,
Wada K, Matsumoto Y, Nomura K, Horiike S, Shimazaki C, Yoshikawa T, Taniwaki
M. Comparison of human herpes virus 8 related primary effusion lymphoma with
human herpes virus 8 unrelated primary effusion lymphoma-like lymphoma on the
basis of HIV: report of 2 cases and review of 212 cases in the literature. Acta
59. Kitamura R, Takahashi T, Nakajima N, Isodono K, Asada S, Ueno H,
Ueyama T, Yoshikawa T, Matsubara H, Oh H. Stage-specific role of endogenous
Smad2 activation in cardiomyogenesis of embryonic stem cells. Circ Res
60. Kin S, Hagiwara A, Nakase Y, Kuriu Y, Nakashima S, Yoshikawa T,
Sakakura C, Otsuji E, Nakamura T, Yamagishi H. Regeneration of skeletal muscle
using in situ tissue engineering on an acellular collagen sponge scaffold in a rabbit
61. Kimura M, Kawahito Y, Obayashi H, Ohta M, Hara H, Adachi T,
Tokunaga D, Hojo T, Hamaguchi M, Omoto A, Ishino H, Wada M, Kohno M,
Tsubouchi Y, Yoshikawa T. A critical role for allograft inflammatory factor-1 in the
pathogenesis of rheumatoid arthritis. J Immunol 2007;178:3316-22.
62. Kimura M, Kawahito Y, Hamaguchi M, Nakamura T, Okamoto M,
Matsumoto Y, Endo H, Yamamoto A, Ishino H, Wada M, Omoto A, Tsubouchi Y,
Kohno M, Yoshikawa T. SKL-2841, a dual antagonist of MCP-1 and MIP-1 beta,
prevents bleomycin-induced skin sclerosis in mice. Biomed Pharmacother
63. Handa O, Naito Y, Yoshikawa T. CagA protein of Helicobacter pylori: a
hijacker of gastric epithelial cell signaling. Biochem Pharmacol 2007;73:1697-702.
64. Hamaguchi M, Kojima T, Takeda N, Nagata C, Takeda J, Sarui H,
Kawahito Y, Yoshida N, Suetsugu A, Kato T, Okuda J, Ida K, Yoshikawa T.
Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World
65. Hamaguchi M, Kojima T, Itoh Y, Harano Y, Fujii K, Nakajima T, Kato T,
Takeda N, Okuda J, Ida K, Kawahito Y, Yoshikawa T, Okanoue T. The Severity of
Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the
Metabolic Syndrome and Visceral Fat Accumulation. Am J Gastroenterol 2007.
66. Hamaguchi M, Kawahito Y, Tsubouchi Y, Kohno M, Yamamoto A, Ishino
H, Wada M, Yoshikawa T. Combination therapy of prednisolone and mizoribine
improves cryoglobulinemic vasculitis with purpura and skin ulcers. Clin Rheumatol
67. Fukui M, Ose H, Nakayama I, Hosoda H, Asano M, Kadono M, Mogami
SI, Hasegawa G, Yoshikawa T, Nakamura N. Association between urinary albumin
excretion and serum dehydroepiandrosterone sulfate concentration in women with
type 2 diabetes. Diabetes Care 2007.
68. Fukui M, Ose H, Nakayama I, Hosoda H, Asano M, Kadono M, Mogami
S, Yamazaki M, Hasegawa G, Yoshikawa T, Nakamura N. Association between
serum testosterone concentration and collagen degradation fragments in men with
type 2 diabetes mellitus. Metabolism 2007;56:1228-32.
69. Fukui M, Ose H, Nakayama I, Hosoda H, Asano M, Kadono M, Mogami
S, Hasegawa G, Yoshikawa T, Nakamura N. Association between urinary albumin
excretion and serum dehydroepiandrosterone sulfate concentrations in women with
type 2 diabetes. Diabetes Care 2007;30:1886-8.
70. Fukui M, Ose H, Kitagawa Y, Yamazaki M, Hasegawa G, Yoshikawa T,
Nakamura N. Relationship between low serum endogenous androgen concentrations
and arterial stiffness in men with type 2 diabetes mellitus. Metabolism
71. Fukui M, Ose H, Kitagawa Y, Kamiuchi K, Nakayama I, Ohta M,
Obayashi H, Yamasaki M, Hasegawa G, Yoshikawa T, Nakamura N. Metabolic
syndrome is not associated with markers of subclinical atherosclerosis, serum
adiponectin and endogenous androgen concentrations in Japanese men with Type 2
diabetes. Diabet Med 2007;24:864-71.
72. Fukui M, Ose H, Hasegawa G, Yoshikawa T, Nakamura N. Association
between urinary albumin excretion and plasma 5-hydroxyindole-3-acetic acid
concentration in men with type 2 diabetes. Diabetes Care 2007;30:2649-51.
73. Aoi W, Niisato N, Sawabe Y, Miyazaki H, Tokuda S, Nishio K,
Yoshikawa T, Marunaka Y. Abnormal expression of ENaC and SGK1 mRNA
induced by dietary sodium in Dahl salt-sensitively hypertensive rats. Cell Biol Int
74. Aoi W, Naito Y, Nakamura T, Akagiri S, Masuyama A, Takano T,
Mizushima K, Yoshikawa T. Inhibitory effect of fermented milk on delayed-onset
muscle damage after exercise. J Nutr Biochem 2007;18:140-5.
75. Yoshida N, Isozaki Y, Takagi T, Takenaka S, Uchikawa R, Arizono N,
Yoshikawa T, Okanoue T. Review article: anti-tryptase therapy in inflammatory
bowel disease. Aliment Pharmacol Ther 2006;24 Suppl 4:249-55.
76. Yoshida N, Imamoto E, Uchiyama K, Kuroda M, Naito Y, Mukaida N,
Kawabe A, Shimada Y, Yoshikawa T, Okanoue T. Molecular mechanisms involved
in interleukin-8 production by normal human oesophageal epithelial cells. Aliment
Pharmacol Ther 2006;24 Suppl 4:219-26.
77. Yamaguchi T, Kamada K, Dayton C, Gaskin FS, Yusof M, Yoshikawa T,
Carter P, Korthuis RJ. Role of eNOS-derived NO in the Postischemic
Anti-inflammatory Effects of Antecedent Ethanol Ingestion in Murine Small
Intestine. Am J Physiol Heart Circ Physiol 2006.
78. Takagi T, Yoshida N, Isozaki Y, Shimozawa M, Katada K, Manabe H,
Hanada O, Kokura S, Ichikawa H, Naito Y, Okanoue T, Yoshikawa T. CV-11974,
angiotensin II type I receptor antagonist, protects against ischemia-reperfusion
injury of the small intestine in rats. Eur J Pharmacol 2006;535:283-90.
79. Takagi T, Naito Y, Tsuboi H, Isozaki Y, Katada K, Suzuki T, Terao K,
Handa O, Kokura S, Ichikawa H, Yoshida N, Okuyama Y, Yagi N, Ueda H,
Yoshikawa T. Increased intestinal luminal carbon monoxide gas in patients with
ulcerative colitis. Aliment Pharmacol Ther 2006;24 Suppl 4:233-8.
80. Sugimoto N, Yoshida N, Nakamura Y, Ichikawa H, Naito Y, Okanoue T,
Yoshikawa T. Influence of vitamin E on gastric mucosal injury induced by
Helicobacter pylori infection. Biofactors 2006;28:9-19.
81. Ohnishi M, Hasegawa G, Yamasaki M, Obayashi H, Fukui M, Nakajima T,
Ichida Y, Ohse H, Mogami S, Yoshikawa T, Nakamura N. Integrin-linked kinase
acts as a pro-survival factor against high glucose-associated osmotic stress in human
mesangial cells. Nephrol Dial Transplant 2006;21:1786-93.
82. Nakajima T, Hasegawa G, Kamiuchi K, Fukui M, Yamasaki M, Tominaga
M, Asano M, Hosoda H, Yoshikawa T, Nakamura N. Differential regulation of
intracellular redox state by extracellular matrix proteins in glomerular mesangial
cells: potential role in diabetic nephropathy. Redox Rep 2006;11:223-30.
83. Naito Y, Yoshikawa T. Oxidative stress involvement and gene expression
in indomethacin-induced gastropathy. Redox Rep 2006;11:243-53.
84. Naito Y, Uchiyama K, Mizushima K, Kuroda M, Akagiri S, Takagi T,
Handa O, Kokura S, Yoshida N, Ichikawa H, Takahashi J, Yoshikawa T. Microarray
profiling of gene expression patterns in glomerular cells of astaxanthin-treated
diabetic mice: a nutrigenomic approach. Int J Mol Med 2006;18:685-95.
85. Naito Y, Uchiyama K, Kuroda M, Takagi T, Kokura S, Yoshida N,
Ichikawa H, Yoshikawa T. Role of pancreatic trypsin in chronic esophagitis induced
by gastroduodenal reflux in rats. J Gastroenterol 2006;41:198-208.
86. Naito Y, Takagi T, Mizushima K, Ueta M, Kinoshita S, Handa O, Kokura
S, Ichikawa H, Yoshida N, Yoshikawa T. Gene expression clusters of a
lipopolysaccharide-stimulated pathway in peripheral blood monocytes of Japanese
patients with Crohn's disease. Aliment Pharmacol Ther 2006;24 Suppl 4:256-65.
87. Naito Y, Takagi T, Katada K, Uchiyama K, Kuroda M, Kokura S,
Ichikawa H, Watabe J, Yoshida N, Okanoue T, Yoshikawa T. Partially hydrolyzed
guar gum down-regulates colonic inflammatory response in dextran sulfate
sodium-induced colitis in mice. J Nutr Biochem 2006;17:402-9.
88. Naito Y, Shimozawa M, Manabe H, Nakabe N, Katada K, Kokura S,
Yoshida N, Ichikawa H, Kon T, Yoshikawa T. Azelnidipine, a new calcium channel
blocker, inhibits endothelial inflammatory response by reducing intracellular levels
of reactive oxygen species. Eur J Pharmacol 2006;546:11-8.
89. Naito Y, Kuroda M, Uchiyama K, Mizushima K, Akagiri S, Takagi T,
Handa O, Kokura S, Yoshida N, Ichikawa H, Yoshikawa T. Inflammatory response
of esophageal epithelium in combined-type esophagitis in rats: a transcriptome
analysis. Int J Mol Med 2006;18:821-8.
90. Naito Y, Katada K, Takagi T, Tsuboi H, Kuroda M, Handa O, Kokura S,
Yoshida N, Ichikawa H, Yoshikawa T. Rosuvastatin reduces rat intestinal
ischemia-reperfusion injury associated with the preservation of endothelial nitric
oxide synthase protein. World J Gastroenterol 2006;12:2024-30.
91. Naito Y, Katada K, Takagi T, Tsuboi H, Isozaki Y, Handa O, Kokura S,
Yoshida N, Ichikawa H, Yoshikawa T. Rosuvastatin, a new HMG-CoA reductase
inhibitor, reduces the colonic inflammatory response in dextran sulfate
sodium-induced colitis in mice. Int J Mol Med 2006;17:997-1004.
92. Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Kin S, Nakase Y,
Ito K, Yamagishi H, Ida H, Yazumi S, Chiba T, Ito Y, Hagiwara A. Down-regulation
of RUNX1, RUNX3 and CBFbeta in hepatocellular carcinomas in an early stage of
hepatocarcinogenesis. Anticancer Res 2006;26:3633-43.
93. Kuroda M, Yoshida N, Ichikawa H, Takagi T, Okuda T, Naito Y, Okanoue
T, Yoshikawa T. Lansoprazole, a proton pump inhibitor, reduces the severity of
indomethacin-induced rat enteritis. Int J Mol Med 2006;17:89-93.
94. Kitawaki J, Kiyomizu M, Obayashi H, Ohta M, Ishihara H, Hasegawa G,
Nakamura N, Yoshikawa T, Honjo H. Synergistic effect of interleukin-6 promoter
(IL6 -634C/G) and intercellular adhesion molecule-1 (ICAM-1 469K/E) gene
polymorphisms on the risk of endometriosis in Japanese women. Am J Reprod
95. Kimura M, Kawahito Y, Hamaguchi M, Nakamura T, Okamoto M,
Matsumoto Y, Endo H, Yamamoto A, Ishino H, Wada M, Omoto A, Tsubouchi Y,
Kohno M, Yoshikawa T. SKL-2841, a dual antagonist of MCP-1 and MIP-1 beta,
prevents bleomycin-induced skin sclerosis in mice. Biomed Pharmacother 2006.
96. Katada K, Naito Y, Mizushima K, Takagi T, Handa O, Kokura S, Ichikawa
H, Yoshida N, Matsui H, Yoshikawa T. Gene expression profiles on hypoxia and
reoxygenation in rat gastric epithelial cells: a high-density DNA microarray analysis.
97. Isozaki Y, Yoshida N, Kuroda M, Takagi T, Handa O, Kokura S, Ichikawa
H, Naito Y, Okanoue T, Yoshikawa T. Effect of a novel water-soluble vitamin E
derivative as a cure for TNBS-induced colitis in rats. Int J Mol Med
98. Isozaki Y, Yoshida N, Kuroda M, Handa O, Takagi T, Kokura S, Ichikawa
H, Naito Y, Okanoue T, Yoshikawa T. Anti-tryptase treatment using nafamostat
mesilate has a therapeutic effect on experimental colitis. Scand J Gastroenterol
99. Iida Y, Oda Y, Nakamori S, Tsunoda S, Kishida T, Gojo S, Shin-Ya M,
Asada H, Imanishi J, Yoshikawa T, Matsubara H, Mazda O. Transthoracic direct
current shock facilitates intramyocardial transfection of naked plasmid DNA infused
via coronary vessels in canines. Gene Ther 2006;13:906-16.
100. Ichida Y, Hasegawa G, Fukui M, Obayashi H, Ohta M, Fujinami A, Ohta
K, Nakano K, Yoshikawa T, Nakamura N. Effect of atorvastatin on in vitro
expression of resistin in adipocytes and monocytes/macrophages and effect of
atorvastatin treatment on serum resistin levels in patients with type 2 diabetes.
101. Handa O, Yoshida N, Fujita N, Tanaka Y, Ueda M, Takagi T, Kokura S,
Naito Y, Okanoue T, Yoshikawa T. Molecular mechanisms involved in
anti-inflammatory effects of proton pump inhibitors. Inflamm Res 2006;55:476-80.
102. Handa O, Kokura S, Adachi S, Takagi T, Naito Y, Tanigawa T, Yoshida N,
Yoshikawa T. Methylparaben potentiates UV-induced damage of skin keratinocytes.
103. Hamaguchi M, Kawahito Y, Tsubouchi Y, Kohno M, Yamamoto A, Ishino
H, Wada M, Yoshikawa T. Combination therapy of prednisolone and mizoribine
improves cryoglobulinemic vasculitis with purpura and skin ulcers. Clin Rheumatol
104. Fukui M, Kitagawa Y, Kamiuchi K, Hasegawa G, Yoshikawa T,
Nakamura N. Low serum dehydroepiandrosterone sulfate concentration is a
predictor for deterioration of urinary albumin excretion in male patients with type 2
diabetes. Diabetes Res Clin Pract 2006;73:47-50.
105. Yoshikawa T, Kawahito Y. [Autoimmune disease]. Nippon Rinsho
106. Yamaguchi T, Yoshida N, Tomatsuri N, Takayama R, Katada K, Takagi T,
Ichikawa H, Naito Y, Okanoue T, Yoshikawa T. Cytokine-induced neutrophil
accumulation in the pathogenesis of acute reflux esophagitis in rats. Int J Mol Med
107. Wada S, Satomi Y, Murakoshi M, Noguchi N, Yoshikawa T, Nishino H.
Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett
108. Ueda-Nishimura T, Niisato N, Miyazaki H, Naito Y, Yoshida N,
Yoshikawa T, Nishino H, Marunaka Y. Synergic action of insulin and genistein on
Na+/K+/2Cl- cotransporter in renal epithelium. Biochem Biophys Res Commun
109. Tsunoda S, Mazda O, Oda Y, Iida Y, Akabame S, Kishida T, Shin-Ya M,
Asada H, Gojo S, Imanishi J, Matsubara H, Yoshikawa T. Sonoporation using
microbubble BR14 promotes pDNA/siRNA transduction to murine heart. Biochem
110. Takakura Y, Yoshioka K, Umekawa T, Kogure A, Toda H, Yoshikawa T,
Yoshida T. Thr54 allele of the FABP2 gene affects resting metabolic rate and
visceral obesity. Diabetes Res Clin Pract 2005;67:36-42.
111. Sakamoto N, Kokura S, Okuda T, Hattori T, Katada K, Isozaki Y, Nakabe
N, Handa O, Takagi T, Ishikawa T, Naito Y, Yoshida N, Yoshikawa T. Heme
oxygenase-1 (Hsp32) is involved in the protection of small intestine by whole body
mild hyperthermia from ischemia/reperfusion injury in rat. Int J Hyperthermia
112. Sakakura C, Miyagawa K, Fukuda K, Kin S, Nakase Y, Kuriu Y,
Nakashima S, Yoshikawa T, Yamaoka N, Sagara Y, Hagiwara A, Yamagishi H. [A
long-term survival case with multiple liver metastases from duodenal
gastrointestinal stromal tumor that was drastically reduced by the treatment with
imatinib]. Gan To Kagaku Ryoho 2005;32:1739-41.
113. Sakakura C, Hasegawa K, Miyagawa K, Nakashima S, Yoshikawa T, Kin
S, Nakase Y, Yazumi S, Yamagishi H, Okanoue T, Chiba T, Hagiwara A. Possible
involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers.
114. Sakakura C, Hagiwara A, Yoshikawa T, Hamada T, Yamagishi H. Huge
ovarian metastasis from jejunal cancer occurring immediately after initial operation.
Hepatogastroenterology 2005;52:425-8.
115. Sakakura C, Hagiwara A, Miyagawa K, Nakashima S, Yoshikawa T, Kin
S, Nakase Y, Ito K, Yamagishi H, Yazumi S, Chiba T, Ito Y. Frequent
downregulation of the runt domain transcription factors RUNX1, RUNX3 and their
cofactor CBFB in gastric cancer. Int J Cancer 2005;113:221-8.
116. Ose H, Fukui M, Kitagawa Y, Hirata C, Ichio N, Kadono M, Mogami S,
Onishi M, Ichida Y, Nakajima T, Hasegawa G, Yoshikawa T, Nakamura N. Efficacy
of glimepiride in patients with poorly controlled insulin-treated type 2 diabetes
117. Omoto A, Kawahito Y, Prudovsky I, Tubouchi Y, Kimura M, Ishino H,
Wada M, Yoshida M, Kohno M, Yoshimura R, Yoshikawa T, Sano H. Copper
chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and
inflammation-associated cachexia in rats. Arthritis Res Ther 2005;7:R1174-82.
118. Nakamura M, Asada M, Atsuda K, Matsui H, Watanabe T, Higuchi K,
Arakawa T, Hibi N, Tsuchimoto K. Lansoprazole binding to the neutrophils in
dextran sulfate sodium-induced rat colitis. Inflammopharmacology 2005;13:303-15.
119. Naito Y, Yoshikawa T. Role of matrix metalloproteinases in inflammatory
bowel disease. Mol Aspects Med 2005;26:379-90.
120. Naito Y, Yoshikawa T. [Role of nitric oxide derived from inducible nitric
oxide synthase in H. pylori-infected gastric mucosal injury]. Nippon Rinsho
121. Naito Y, Takano H, Yoshikawa T. Oxidative stress-related molecules as a
therapeutic target for inflammatory and allergic diseases. Curr Drug Targets
122. Naito Y, Shimozawa M, Kuroda M, Nakabe N, Manabe H, Katada K,
Kokura S, Ichikawa H, Yoshida N, Noguchi N, Yoshikawa T. Tocotrienols reduce
25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting
the surface expression of adhesion molecules. Atherosclerosis 2005;180:19-25.
123. Naito Y, Mizushima K, Yoshikawa T. Global analysis of gene expression
in gastric ischemia-reperfusion: a future therapeutic direction for mucosal protective
drugs. Dig Dis Sci 2005;50 Suppl 1:S45-55.
124. Naito Y, Kajikawa H, Mizushima K, Shimozawa M, Kuroda M, Katada K,
Takagi T, Handa O, Kokura S, Ichikawa H, Yoshida N, Matsui H, Yoshikawa T.
Rebamipide, a gastro-protective drug, inhibits indomethacin-induced apoptosis in
cultured rat gastric mucosal cells: association with the inhibition of growth arrest
and DNA damage-induced 45 alpha expression. Dig Dis Sci 2005;50 Suppl
125. Naito Y, Akagiri S, Uchiyama K, Kokura S, Yoshida N, Hasegawa G,
Nakamura N, Ichikawa H, Toyokuni S, Ijichi T, Yoshikawa T. Reduction of
diabetes-induced renal oxidative stress by a cantaloupe melon extract/gliadin
biopolymers, oxykine, in mice. Biofactors 2005;23:85-95.
126. Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Kin S, Nakase Y,
Fukuda K, Hagiwara A, Okazaki Y, Hayashizaki Y, Yamagishi H. [Analysis of Reg
IV expression in peritoneal dissemination of gastric cancer using real-time RT-PCR].
127. Kokura S, Yoshida N, Sakamoto N, Ishikawa T, Takagi T, Higashihara H,
Nakabe N, Handa O, Naito Y, Yoshikawa T. The radical scavenger edaravone
enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing
apoptosis via inhibition of NF-kappaB. Cancer Lett 2005;229:223-33.
128. Kokura S, Yoshida N, Ishikawa T, Higashihara H, Sakamoto N, Takagi T,
Uchiyama K, Naito Y, Mazda O, Okanoue T, Yoshikawa T. Interleukin-10 plasmid
DNA inhibits subcutaneous tumor growth of Colon26 adenocarcinoma in mice.
129. Kogure A, Yoshida T, Takakura Y, Umekawa T, Hioki C, Yoshioka K,
Yoshimoto K, Yoshikawa T. Effect of ultrasonic stimulation on mRNA abundance
of uncoupling protein (UCP) 2 and UCP 3 in gastrocnemius muscle of rats. Clin Exp
130. Katada K, Yoshida N, Isozaki Y, Tomatsuri N, Ichikawa H, Naito Y,
Okanoue T, Yoshikawa T. Prevention by rebamipide of acute reflux esophagitis in
rats. Dig Dis Sci 2005;50 Suppl 1:S97-S103.
131. Isozaki Y, Yoshida N, Ichikawa H, Kuroda M, Kokura S, Naito Y,
Okanoue T, Yoshikawa T. A novel water-soluble vitamin E derivative protects
against aspirin-induced gastric mucosal injury in rats. Int J Mol Med
132. Ishii M, Hasegawa G, Fukui M, Obayashi H, Ohta M, Ogata M, Yoshioka
K, Kitagawa Y, Nakano K, Yoshikawa T, Nakamura N. Clinical and genetic
characteristics of diabetic patients with high-titer (>10,000 U/ml) of antibodies to
glutamic acid decarboxylase. Immunol Lett 2005;99:180-5.
133. Inoue K, Takano H, Yanagisawa R, Sakurai M, Shimada A, Sato H, Kato
Y, Yoshikawa T. Antioxidative role of urinary trypsin inhibitor in acute lung injury
induced by lipopolysaccharide. Int J Mol Med 2005;16:1029-33.
134. Hasegawa G, Yamamoto Y, Zhi JG, Tanino Y, Yamasaki M, Yano M,
Nakajima T, Fukui M, Yoshikawa T, Nakamura N. Daily profile of plasma %CoQ10
level, a biomarker of oxidative stress, in patients with diabetes manifesting
postprandial hyperglycaemia. Acta Diabetol 2005;42:179-81.
135. Hasegawa G, Ohta M, Ichida Y, Obayashi H, Shigeta M, Yamasaki M,
Fukui M, Yoshikawa T, Nakamura N. Increased serum resistin levels in patients
with type 2 diabetes are not linked with markers of insulin resistance and adiposity.
136. Fukui M, Kitagawa Y, Nakamura N, Kadono M, Hasegawa G, Yoshikawa
T. Association between alcohol consumption and serum dehydroepiandrosterone
sulphate concentration in men with Type 2 diabetes: a link to decreased
cardiovascular risk. Diabet Med 2005;22:1446-50.
137. Yoshikawa T, Hagiwara A, Nakashima S, Miyagawa K, Kuriu Y, Kin S,
Nakase Y, Fukuda K, Sakakura C, Otsuji E, Sonoyama T, Yamagishi H. [A trial of
the new procedure of sentinel node biopsy in the lower rectal cancer by a transsacral
approach]. Gan To Kagaku Ryoho 2004;31:1746-8.
138. Yoshikawa K, Nakata Y, Yamada K, Nakagawa M. Early pathological
changes in the parkinsonian brain demonstrated by diffusion tensor MRI. J Neurol
139. Yoshida T, Shiga K, Yoshikawa K, Yamada K, Nakagawa M. White matter
loss in the splenium of the corpus callosum in a case of posterior cortical atrophy: a
diffusion tensor imaging study. Eur Neurol 2004;52:77-81.
140. Yoshida N, Uchiyama K, Kuroda M, Sakuma K, Kokura S, Ichikawa H,
Naito Y, Takemura T, Yoshikawa T, Okanoue T. Interleukin-8 expression in the
esophageal mucosa of patients with gastroesophageal reflux disease. Scand J
141. Yoshida N, Kassai K, Murase H, Tanaka Y, Kokura S, Ichikawa H, Naito
Y, Okanoue T, Yoshikawa T. Effects of Helicobacter pylori water extract on
expression of endothelial adhesion molecules. Can J Gastroenterol 2004;18:387-91.
142. Yano M, Hasegawa G, Ishii M, Yamasaki M, Fukui M, Nakamura N,
Yoshikawa T. Short-term exposure of high glucose concentration induces generation
of reactive oxygen species in endothelial cells: implication for the oxidative stress
associated with postprandial hyperglycemia. Redox Rep 2004;9:111-6.
143. Uchiyama K, Takano H, Yanagisawa R, Inoue K, Naito Y, Yoshida N,
Yoshino S, Murase H, Ichinose T, Yoshikawa T. A novel water-soluble vitamin E
derivative prevents acute lung injury by bacterial endotoxin. Clin Exp Pharmacol
144. Tomatsuri N, Yoshida N, Takagi T, Katada K, Isozaki Y, Imamoto E,
Uchiyama K, Kokura S, Ichikawa H, Naito Y, Okanoue T, Yoshikawa T. Edaravone,
a newly developed radical scavenger, protects against ischemia-reperfusion injury of
the small intestine in rats. Int J Mol Med 2004;13:105-9.
145. Teramoto M, Kitawaki J, Koshiba H, Kitaoka Y, Obayashi H, Hasegawa G,
Nakamura N, Yoshikawa T, Matsushita M, Maruya E, Saji H, Ohta M, Honjo H.
Genetic contribution of tumor necrosis factor (TNF)-alpha gene promoter (-1031,
-863 and -857) and TNF receptor 2 gene polymorphisms in endometriosis
susceptibility. Am J Reprod Immunol 2004;51:352-7.
146. Takano H, Osakabe N, Sanbongi C, Yanagisawa R, Inoue K, Yasuda A,
Natsume M, Baba S, Ichiishi E, Yoshikawa T. Extract of Perilla frutescens enriched
for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic
rhinoconjunctivitis in humans. Exp Biol Med (Maywood) 2004;229:247-54.
147. Takagi T, Naito Y, Ichikawa H, Tomatsuri N, Katada K, Isozaki Y, Kuroda
M, Kokura S, Yoshida N, Yoshikawa T. A PPAR-gamma ligand,
15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced
by ischemia-reperfusion in rats. Redox Rep 2004;9:376-81.
148. Shimozawa M, Naito Y, Manabe H, Uchiyama K, Kuroda M, Katada K,
Yoshida N, Yoshikawa T. 7-Ketocholesterol enhances the expression of adhesion
molecules on human aortic endothelial cells by increasing the production of reactive
oxygen species. Redox Rep 2004;9:370-5.
149. Shimozawa M, Naito Y, Manabe H, Uchiyama K, Katada K, Kuroda M,
Nakabe N, Yoshida N, Yoshikawa T. The inhibitory effect of alacepril, an
angiotensin-converting enzyme inhibitor, on endothelial inflammatory response
induced by oxysterol and TNF-alpha. Redox Rep 2004;9:354-9.
150. Sakakura C, Takemura M, Miyagawa K, Fukuda K, Shimomura K, Kin S,
Nakase Y, Kuriu Y, Nakashima S, Yoshikawa T, Ueda Y, Fujiyama J, Sonoyama T,
Okazaki Y, Hayashizaki Y, Hagiwara A, Yamagishi H. [Utility of dopa
decarboxylase as a novel marker for the detection of peritoneal micro-metastases of
gastric cancer with realtime RT-PCR]. Gan To Kagaku Ryoho 2004;31:1906-8.
151. Sakakura C, Takemura M, Hagiwara A, Shimomura K, Miyagawa K,
Nakashima S, Yoshikawa T, Takagi T, Kin S, Nakase Y, Fujiyama J, Hayasizaki Y,
Okazaki Y, Yamagishi H. Overexpression of dopa decarboxylase in peritoneal
dissemination of gastric cancer and its potential as a novel marker for the detection
of peritoneal micrometastases with real-time RT-PCR. Br J Cancer 2004;90:665-71.
152. Omoto A, Kawahito Y, Muraguchi N, Takao T, Yamamoto A, Kimura M,
Tsubouchi Y, Inoue M, Yoshikawa T. [A case report of Churg-Strauss syndrome
combined with various vessel diseases]. Nihon Rinsho Meneki Gakkai Kaishi
153. Naito Y, Yoshikawa T. [Oxidative stress evaluated by oxidative stress
profile (OSP)]. Nippon Rinsho 2004;62 Suppl 11:525-8.
154. Naito Y, Yoshikawa T. Thiazolidinediones: a new class of drugs for the
therapy of ischemia-reperfusion injury. Drugs Today (Barc) 2004;40:423-30.
155. Naito Y, Yoshida N, Yoshikawa T. [Pro-inflammatory chemokine IL-8 in
gastroesophageal reflux disease]. Nippon Rinsho 2004;62:1447-53.
156. Naito Y, Uchiyama K, Kuroda M, Mizushima K, Aoi W, Kokura S,
Ichikawa H, Yoshida N, Yoshikawa T. Laser capture microdissection/GeneChip
analysis of gene expression in glomerular cells in diabetic db/db mice. Redox Rep
157. Naito Y, Uchiyama K, Aoi W, Hasegawa G, Nakamura N, Yoshida N,
Maoka T, Takahashi J, Yoshikawa T. Prevention of diabetic nephropathy by
treatment with astaxanthin in diabetic db/db mice. Biofactors 2004;20:49-59.
158. Naito Y, Takagi T, Yoshikawa T. Heme oxygenase-1: a new therapeutic
target for inflammatory bowel disease. Aliment Pharmacol Ther 2004;20 Suppl
159. Naito Y, Takagi T, Uchiyama K, Kuroda M, Kokura S, Ichikawa H,
Yanagisawa R, Inoue K, Takano H, Satoh M, Yoshida N, Okanoue T, Yoshikawa T.
Reduced intestinal inflammation induced by dextran sodium sulfate in
interleukin-6-deficient mice. Int J Mol Med 2004;14:191-6.
160. Naito Y, Takagi T, Kuroda M, Katada K, Ichikawa H, Kokura S, Yoshida
N, Okanoue T, Yoshikawa T. An orally active matrix metalloproteinase inhibitor,
ONO-4817, reduces dextran sulfate sodium-induced colitis in mice. Inflamm Res
161. Naito Y, Takagi T, Ichikawa H, Tomatsuri N, Kuroda M, Isozaki Y, Katada
K, Uchiyama K, Kokura S, Yoshida N, Okanoue T, Yoshikawa T. A novel potent
inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal
ischemia-reperfusion injury in rats. Nitric Oxide 2004;10:170-7.
162. Naito Y, Shimozawa M, Manabe H, Kuroda M, Tomatsuri N, Uchiyama K,
Takagi T, Yoshida N, Yoshikawa T. Inhibitory effects of red wine extracts on
endothelial-dependent adhesive interactions with monocytes induced by oxysterols.
163. Kon T, Tanigawa T, Hayamizu K, Shen M, Tsuji T, Naito Y, Yoshikawa T.
Singlet oxygen quenching activity of human serum. Redox Rep 2004;9:325-30.
164. Kokura S, Yoshida N, Imamoto E, Ueda M, Ishikawa T, Uchiyama K,
Kuchide M, Naito Y, Okanoue T, Yoshikawa T. Anoxia/reoxygenation
down-regulates the expression of E-cadherin in human colon cancer cell lines.
165. Kitawaki J, Koshiba H, Kitaoka Y, Teramoto M, Hasegawa G, Nakamura
N, Yoshikawa T, Ohta M, Obayashi H, Honjo H. Interferon-gamma gene
dinucleotide (CA) repeat and interleukin-4 promoter region (-590C/T)
polymorphisms in Japanese patients with endometriosis. Hum Reprod
166. Katada K, Naito Y, Shimozawa M, Mizushima K, Kuroda M, Takagi T,
Kokura S, Ichikawa H, Yoshida N, Matsui H, Yoshikawa T. Gene expression
analysis following hypoxia-reoxygenation in rat gastric epithelial cells using a
high-density oligonucleotide array. Redox Rep 2004;9:337-42.
167. Ito K, Shimada J, Kato D, Toda S, Takagi T, Naito Y, Yoshikawa T,
Kitamura N. Protective effects of preischemic treatment with pioglitazone, a
peroxisome proliferator-activated receptor-gamma ligand, on lung
ischemia-reperfusion injury in rats. Eur J Cardiothorac Surg 2004;25:530-6.
168. Imamoto E, Yoshida N, Uchiyama K, Kuroda M, Kokura S, Ichikawa H,
Naito Y, Tanigawa T, Yoshikawa T. Inhibitory effect of pioglitazone on expression
of adhesion molecules on neutrophils and endothelial cells. Biofactors
169. Ichikawa H, Yoshida N, Takagi T, Tomatsuri N, Katada K, Isozaki Y,
Uchiyama K, Naito Y, Okanoue T, Yoshikawa T. Lansoprazole ameliorates intestinal
mucosal damage induced by ischemia-reperfusion in rats. World J Gastroenterol
170. Ichikawa H, Takagi T, Uchiyama K, Higashihara H, Katada K, Isozaki Y,
Naito Y, Yoshida N, Yoshikawa T. Rotenone, a mitochondrial electron transport
inhibitor, ameliorates ischemia-reperfusion-induced intestinal mucosal damage in
171. Hioki C, Yoshida T, Kogure A, Takakura Y, Umekawa T, Yoshioka K,
Shimatsu A, Yoshikawa T. Effects of growth hormone (GH) on mRNA levels of
uncoupling proteins 1, 2, and 3 in brown and white adipose tissues and skeletal
muscle in obese mice. Horm Metab Res 2004;36:607-13.
172. Higashihara H, Kokura S, Imamoto E, Ueda M, Naito Y, Yoshida N,
Yoshikawa T. Hypoxia-reoxygenation enhances interleukin-8 production from U937
human monocytic cells. Redox Rep 2004;9:365-9.
173. Hashimoto T, Ibi M, Matsuno K, Nakashima S, Tanigawa T, Yoshikawa T,
Yabe-Nishimura C. An endogenous metabolite of dopamine,
3,4-dihydroxyphenylethanol, acts as a unique cytoprotective agent against oxidative
stress-induced injury. Free Radic Biol Med 2004;36:555-64.
174. Harusato A, Naito Y, Hattori T, Yoshida N, Hagiwara A, Okanoue T,
Yoshikawa T. [A case of Castleman disease arising from lesser sac]. Nippon
Shokakibyo Gakkai Zasshi 2004;101:168-72.
175. Handa O, Naito Y, Takagi T, Shimozawa M, Kokura S, Yoshida N, Matsui
H, Cepinskas G, Kvietys PR, Yoshikawa T. Tumor necrosis factor-alpha-induced
cytokine-induced neutrophil chemoattractant-1 (CINC-1) production by rat gastric
epithelial cells: role of reactive oxygen species and nuclear factor-kappaB. J
176. Fukui M, Kitagawa Y, Nakamura N, Kadono M, Hasegawa G, Yoshikawa
T. Association between urinary albumin excretion and serum
dehydroepiandrosterone sulfate concentration in male patients with type 2 diabetes:
a possible link between urinary albumin excretion and cardiovascular disease.
177. Aoi W, Naito Y, Takanami Y, Kawai Y, Sakuma K, Ichikawa H, Yoshida N,
Yoshikawa T. Oxidative stress and delayed-onset muscle damage after exercise.
178. Aoi W, Ichiishi E, Sakamoto N, Tsujimoto A, Tokuda H, Yoshikawa T.
Effect of exercise on hepatic gene expression in rats: a microarray analysis. Life Sci
179. Yoshikawa K, Matsumoto M, Hamanaka M, Nakagawa M. A case of
manganese induced parkinsonism in hereditary haemorrhagic telangiectasia. J
Neurol Neurosurg Psychiatry 2003;74:1312-4.
180. Yoshida N, Yoshikawa T. Defense mechanism of the esophageal mucosa
and esophageal inflammation. J Gastroenterol 2003;38 Suppl 15:31-4.
181. Yoshida N, Ishikawa T, Ichiishi E, Yoshida Y, Hanashiro K, Kuchide M,
Uchiyama K, Kokura S, Ichikawa H, Naito Y, Yamamura Y, Okanoue T, Yoshikawa
T. The effect of rebamipide on Helicobacter pylori extract-mediated changes of gene
expression in gastric epithelial cells. Aliment Pharmacol Ther 2003;18 Suppl
182. Yamada K, Mori S, Nakamura H, Ito H, Kizu O, Shiga K, Yoshikawa K,
Makino M, Yuen S, Kubota T, Tanaka O, Nishimura T. Fiber-tracking method
reveals sensorimotor pathway involvement in stroke patients. Stroke
183. Ueda M, Kokura S, Imamoto E, Naito Y, Handa O, Takagi T, Yoshida N,
Yoshikawa T. Blocking of NF-kappaB activation enhances the tumor necrosis factor
alpha-induced apoptosis of a human gastric cancer cell line. Cancer Lett
184. Tsunoda S, Takano H, Inoue K, Yoshikawa T. A case of lupus peritonitis
and cystitis after ovulation induction therapy. Am J Obstet Gynecol 2003;189:888-9.
185. Omatsu T, Ichikawa H, Kawahito Y, Ashihara E, Yamamoto A, Kadoya M,
Takegami T, Takanashi Y, Naito Y, Yoshida N, Sugino S, Yoshikawa T. [A case of
advanced gastric cancer with bone metastases and DIC responding to oral
administration of TS-1]. Gan To Kagaku Ryoho 2003;30:869-73.
186. Nakamura N, Hasegawa G, Obayashi H, Yamazaki M, Ogata M, Nakano
K, Yoshikawa T, Watanabe A, Kinoshita S, Fujinami A, Ohta M, Imamura Y, Ikeda
T. Increased concentration of pentosidine, an advanced glycation end product, and
interleukin-6 in the vitreous of patients with proliferative diabetic retinopathy.
Diabetes Res Clin Pract 2003;61:93-101.
187. Naito Y, Takagi T, Handa O, Ishikawa T, Nakagawa S, Yamaguchi T,
Yoshida N, Minami M, Kita M, Imanishi J, Yoshikawa T. Enhanced intestinal
inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha
deficient mice. J Gastroenterol Hepatol 2003;18:560-9.
188. Matsumoto N, Manabe H, Ochiai J, Fujita N, Takagi T, Uemura M, Naito
Y, Yoshida N, Oka S, Yoshikawa T. An AT1-receptor antagonist and an
angiotensin-converting enzyme inhibitor protect against hypoxia-induced apoptosis
in human aortic endothelial cells through upregulation of endothelial cell nitric
oxide synthase activity. Shock 2003;19:547-52.
189. Kuchide M, Tokuda H, Takayasu J, Enjo F, Ishikawa T, Ichiishi E, Naito Y,
Yoshida N, Yoshikawa T, Nishino H. Cancer chemopreventive effects of oral
feeding alpha-tocopherol on ultraviolet light B induced photocarcinogenesis of
hairless mouse. Cancer Lett 2003;196:169-77.
190. Kokura S, Yoshikawa T. [Gene therapy for colon cancer targeting
NF-kappa B]. Nippon Rinsho 2003;61 Suppl 7:515-8.
191. Kokura S, Yoshida N, Ueda M, Imamoto E, Ishikawa T, Takagi T, Naito Y,
Okanoue T, Yoshikawa T. Hyperthermia enhances tumor necrosis factor
alpha-induced apoptosis of a human gastric cancer cell line. Cancer Lett
192. Kimura F, Hasegawa G, Obayashi H, Adachi T, Hara H, Ohta M, Fukui M,
Kitagawa Y, Park H, Nakamura N, Nakano K, Yoshikawa T. Serum extracellular
superoxide dismutase in patients with type 2 diabetes: relationship to the
development of micro- and macrovascular complications. Diabetes Care
193. Ishikawa T, Yoshida N, Tokuda H, Ichiishi E, Kuchide M, Kokura S, Naito
Y, Toyokuni S, Nishino H, Yoshikawa T. Tumor initiating activity of Helicobacter
pylori water extract on mouse skin carcinogenesis. Cancer Lett 2003;191:41-7.
194. Ishikawa T, Yoshida N, Higashihara H, Inoue M, Uchiyama K, Takagi T,
Handa O, Kokura S, Naito Y, Okanoue T, Yoshikawa T. Different effects of
constitutive nitric oxide synthase and heme oxygenase on pulmonary or liver
metastasis of colon cancer in mice. Clin Exp Metastasis 2003;20:445-50.
195. Ichikawa H, Yoshida N, Takano H, Ishikawa T, Handa O, Takagi T, Naito
Y, Murase H, Yoshikawa T. A novel vitamin E derivative (TMG) protects against
gastric mucosal damage induced by ischemia and reperfusion in rats. Dig Dis Sci
196. Hasegawa G, Obayashi H, Kamiuchi K, Nakai M, Kanatsuna T,
Yamaguchi M, Tanaka T, Shigeta H, Fujii M, Yoshikawa T, Nakamura N. The
association between end-stage diabetic nephropathy and methylenetetrahydrofolate
reductase genotype with macroangiopathy in type 2 diabetes mellitus. Exp Clin
197. Aoi W, Naito Y, Sakuma K, Kuchide M, Tokuda H, Maoka T, Toyokuni S,
Oka S, Yasuhara M, Yoshikawa T. Astaxanthin limits exercise-induced skeletal and
cardiac muscle damage in mice. Antioxid Redox Signal 2003;5:139-44.
198. Yoshikawa T. Introduction to serial reviews: vascular dysfunction and free
radicals. Free Radic Biol Med 2002;33:425-6.
199. Yoshida N, Yoshikawa T. Effect of Helicobacter pylori-mediated
inflammation on nonsteroidal anti-inflammatory drugs-induced gastric mucosal
injury. Keio J Med 2002;51 Suppl 2:45-50.
200. Yoshida N, Sugimoto N, Ochiai J, Nakamura Y, Ichikawa H, Naito Y,
Yoshikawa T. Role of elastase and active oxygen species in gastric mucosal injury
induced by aspirin administration in Helicobacter pylori-infected Mongolian gerbils.
Aliment Pharmacol Ther 2002;16 Suppl 2:191-7.
201. Yoshida N, Sugimoto N, Hirayama F, Nakamura Y, Ichikawa H, Naito Y,
Yoshikawa T. Helicobacter pylori infection potentiates aspirin induced gastric
mucosal injury in Mongolian gerbils. Gut 2002;50:594-8.
202. Yoshida N, Murase H, Kunieda T, Toyokuni S, Tanaka T, Terao J, Naito Y,
Tanigawa T, Yoshikawa T. Inhibitory effect of a novel water-soluble vitamin E
derivative on atherosclerosis in rabbits. Atherosclerosis 2002;162:111-7.
203. Uemura M, Manabe H, Yoshida N, Fujita N, Ochiai J, Matsumoto N,
Takagi T, Naito Y, Yoshikawa T. Alpha-tocopherol prevents apoptosis of vascular
endothelial cells via a mechanism exceeding that of mere antioxidation. Eur J
204. Uchiyama K, Naito Y, Hasegawa G, Nakamura N, Takahashi J, Yoshikawa
T. Astaxanthin protects beta-cells against glucose toxicity in diabetic db/db mice.
205. Tegoshi H, Hasegawa G, Obayashi H, Nakano K, Kitagawa Y, Fukui M,
Matsuo S, Deguchi M, Ohta M, Nishimura M, Nakamura N, Yoshikawa T.
Polymorphisms of interferon-gamma gene CA-repeat and interleukin-10 promoter
region (-592A/C) in Japanese type I diabetes. Hum Immunol 2002;63:121-8.
206. Takagi T, Naito Y, Tomatsuri N, Handa O, Ichikawa H, Yoshida N,
Yoshikawa T. Pioglitazone, a PPAR-gamma ligand, provides protection from
dextran sulfate sodium-induced colitis in mice in association with inhibition of the
NF-kappaB-cytokine cascade. Redox Rep 2002;7:283-9.
207. Sakamoto S, Okanoue T, Itoh Y, Nakagawa Y, Nakamura H, Morita A,
Daimon Y, Sakamoto K, Yoshida N, Yoshikawa T, Kashima K. Involvement of
Kupffer cells in the interaction between neutrophils and sinusoidal endothelial cells
208. Ochiai J, Takano H, Ichikawa H, Naito Y, Yoshida N, Yanagisawa R,
Yoshino S, Murase H, Yoshikawa T. A novel water-soluble vitamin E derivative,
2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol, protects
against acute lung injury and mortality in endotoxemic rats. Shock 2002;18:580-4.
209. Nakata Y, Shiga K, Yoshikawa K, Mizuno T, Mori S, Yamada K,
Nakajima K. Subclinical brain hemorrhages in Alzheimer's disease: evaluation by
magnetic resonance T2*-weighted images. Ann N Y Acad Sci 2002;977:169-72.
210. Naito Y, Yoshikawa T. [Reactive oxygen species and free radical reactions
are involved in the pathogenesis of non-steroidal anti-inflammatory drugs-induced
gastric mucosal injury]. Nippon Rinsho 2002;60 Suppl 2:211-6.
211. Naito Y, Yoshikawa T. Molecular and cellular mechanisms involved in
Helicobacter pylori-induced inflammation and oxidative stress. Free Radic Biol
212. Naito Y, Takagi T, Uchiyama K, Handa O, Tomatsuri N, Imamoto E,
Kokura S, Ichikawa H, Yoshida N, Yoshikawa T. Suppression of intestinal
ischemia-reperfusion injury by a specific peroxisome proliferator-activated
receptor-gamma ligand, pioglitazone, in rats. Redox Rep 2002;7:294-9.
213. Naito Y, Takagi T, Ishikawa T, Handa O, Matsumoto N, Yagi N,
Matsuyama K, Yoshida N, Yoshikawa T, Kotake Y.
alpha-Phenyl-N-tert-butylnitrone provides protection from dextran sulfate
sodium-induced colitis in mice. Antioxid Redox Signal 2002;4:195-206.
214. Naito Y, Handa O, Takagi T, Ishikawa T, Imamoto E, Nakagawa S,
Yamaguchi T, Yoshida N, Matsui H, Yoshikawa T. Ubiquitin-proteasome inhibitor
enhances tumour necrosis factor-alpha-induced apoptosis in rat gastric epithelial
cells. Aliment Pharmacol Ther 2002;16 Suppl 2:59-66.
215. Murotani Y, Kuroda J, Kimura S, Terao K, Fukiya E, Ozawa M,
Kobayashi Y, Yoshikawa T. Non-myeloablative haematopoietic stem cell
transplantation for severe aplastic anaemia with various complications. Clin Lab
216. Kuroda J, Kimura S, Kobayashi Y, Wada K, Uoshima N, Yoshikawa T.
Unusual myelodysplastic syndrome with the initial presentation mimicking
idiopathic thrombocytopenic purpura. Acta Haematol 2002;108:139-43.
217. Kokura S, Yoshida N, Yoshikawa T. Anoxia/reoxygenation-induced
leukocyte-endothelial cell interactions. Free Radic Biol Med 2002;33:427-32.
218. Kokura S, Nakagawa S, Hara T, Boku Y, Naito Y, Yoshida N, Yoshikawa
T. Enhancement of lipid peroxidation and of the antitumor effect of hyperthermia
upon combination with oral eicosapentaenoic acid. Cancer Lett 2002;185:139-44.
219. Kogure A, Sakane N, Takakura Y, Umekawa T, Yoshioka K, Nishino H,
Yamamoto T, Kawada T, Yoshikawa T, Yoshida T. Effects of caffeine on the
uncoupling protein family in obese yellow KK mice. Clin Exp Pharmacol Physiol
220. Kitawaki J, Obayashi H, Ohta M, Kado N, Ishihara H, Koshiba H, Kusuki
I, Tsukamoto K, Hasegawa G, Nakamura N, Yoshikawa T, Honjo H. Genetic
contribution of the interleukin-10 promoter polymorphism in endometriosis
susceptibility. Am J Reprod Immunol 2002;47:12-8.
221. Kitamura A, Hasegawa G, Obayashi H, Kamiuchi K, Ishii M, Yano M,
Tanaka T, Yamaguchi M, Shigeta H, Ogata M, Nakamura N, Yoshikawa T.
Interleukin-6 polymorphism (-634C/G) in the promotor region and the progression
of diabetic nephropathy in type 2 diabetes. Diabet Med 2002;19:1000-5.
222. Kawata E, Kuroda J, Kimura S, Kamitsuji Y, Kobayashi Y, Yoshikawa T.
Aplastic anemia evolving into overt myelodysplastic syndrome/acute myeloid
leukemia with t(3;5)(p25;q31). Cancer Genet Cytogenet 2002;137:91-4.
223. Kashiwagi N, Nakano M, Saniabadi AR, Adachi M, Yoshikawa T.
Anti-inflammatory effect of granulocyte and monocyte adsorption apheresis in a
rabbit model of immune arthritis. Inflammation 2002;26:199-205.
224. Kamiuchi K, Hasegawa G, Obayashi H, Kitamura A, Ishii M, Yano M,
Kanatsuna T, Yoshikawa T, Nakamura N. Intercellular adhesion molecule-1
(ICAM-1) polymorphism is associated with diabetic retinopathy in Type 2 diabetes
225. Kamiuchi K, Hasegawa G, Obayashi H, Kitamura A, Ishii M, Yano M,
Kanatsuna T, Yoshikawa T, Nakamura N. Leukocyte-endothelial cell adhesion
molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in
type 2 diabetes mellitus. J Diabetes Complications 2002;16:333-7.
226. Kado N, Kitawaki J, Obayashi H, Ishihara H, Koshiba H, Kusuki I,
Tsukamoto K, Hasegawa G, Nakamura N, Yoshikawa T, Honjo H. Association of
the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in
Japanese women. Hum Reprod 2002;17:897-902.
227. Ichikawa H, Naito Y, Takagi T, Tomatsuri N, Yoshida N, Yoshikawa T. A
specific peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand,
pioglitazone, ameliorates gastric mucosal damage induced by ischemia and
reperfusion in rats. Redox Rep 2002;7:343-6.
228. Handa O, Yoshida N, Tanaka Y, Ueda M, Ishikawa T, Takagi T,
Matsumoto N, Naito Y, Yoshikawa T. Inhibitory effect of polaprezinc on the
inflammatory response to Helicobacter pylori. Can J Gastroenterol 2002;16:785-9.
229. Handa O, Naito Y, Takagi T, Ishikawa T, Ueda M, Matsumoto N, Kokura
S, Ichikawa H, Yoshida N, Shimoi K, Yoshikawa T. Inhibitory effects of catechins
on neutrophil-dependent gastric inflammation. Redox Rep 2002;7:324-8.
230. Yoshikawa T, Uchiyama K, Naito Y, Yoshida N. [Gastrointestinal
manifestations in collagen disease]. Nippon Shokakibyo Gakkai Zasshi
231. Yoshikawa T, Naito Y. The Role of Neutrophils and Inflammation in
Gastric Mucosal Injury. Free Radic Res 2001;33:785-794.
232. Yoshida N, Yamaguchi T, Nakagawa S, Nakamura Y, Naito Y, Yoshikawa
T. Role of P-selectin and intercellular adhesion molecule-1 in TNB-induced colitis
in rats. Digestion 2001;63 Suppl 1:81-6.
233. Naito Y, Yoshikawa T, Yagi N, Matsuyama K, Yoshida N, Seto K, Yoneta
T. Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and
TNF-alpha expression in rats with aspirin-induced gastric mucosal injury. Dig Dis
234. Naito Y, Takagi T, Matsuyama K, Yoshida N, Yoshikawa T. Pioglitazone,
a specific PPAR-gamma ligand, inhibits aspirin-induced gastric mucosal injury in
rats. Aliment Pharmacol Ther 2001;15:865-73.
235. Naito Y, Takagi T, Ishikawa T, Handa O, Matsumoto N, Yagi N,
Matsuyama K, Yoshida N, Yoshikawa T. The inducible nitric oxide synthase
inhibitor ONO-1714 blunts dextran sulfate sodium colitis in mice. Eur J Pharmacol
236. Naito Y, Takagi T, Handa O, Ishikawa T, Matsumoto N, Yoshida N, Kato
H, Ando T, Takemura T, Itani K, Hisatomi H, Tsuchihashi Y, Yoshikawa T.
Telomerase activity and expression of telomerase RNA component and catalytic
subunits in precancerous and cancerous colorectal lesions. Tumour Biol
237. Kuroda J, Omoto A, Fujiki H, Okugawa K, Tamai H, Yamagishi H,
Kobayashi Y, Yoshikawa T. Primary hepatic Burkitt's lymphoma with chronic
hepatitis C. Acta Haematol 2001;105:237-40.
238. Inoue K, Kawahito Y, Tsubouchi Y, Kohno M, Yoshimura R, Yoshikawa T,
Sano H. Expression of peroxisome proliferator-activated receptor gamma in renal
cell carcinoma and growth inhibition by its agonists. Biochem Biophys Res
239. Higashihara H, Yoshida N, Yoshikawa T. [Hyperthermia for
hepatocellular carcinoma]. Nippon Rinsho 2001;59 Suppl 6:650-3.
240. Yoshikawa T, Yoshida N. Vitamin E and leukocyte-endothelial cell
interactions. Antioxid Redox Signal 2000;2:821-5.
241. Yoshikawa T, Tanigawa M, Tanigawa T, Imai A, Hongo H, Kondo M.
Enhancement of nitric oxide generation by low frequency electromagnetic field.
242. Yoshikawa T, Naito Y. The role of neutrophils and inflammation in gastric
mucosal injury. Free Radic Res 2000;33:785-94.
243. Yoshikawa T, Mori A. Preface. Pathophysiology 2000;7:81.
244. Yoshida N, Yoshikawa T, Tanaka Y, Fujita N, Kassai K, Naito Y, Kondo
M. A new mechanism for anti-inflammatory actions of proton pump
inhibitors--inhibitory effects on neutrophil-endothelial cell interactions. Aliment
Pharmacol Ther 2000;14 Suppl 1:74-81.
245. Yoshida N, Manabe H, Terasawa Y, Nishimura H, Enjo F, Nishino H,
Yoshikawa T. Inhibitory effects of vitamin E on endothelial-dependent adhesive
interactions with leukocytes induced by oxidized low density lipoprotein. Biofactors
246. Terasawa Y, Manabe H, Yoshida N, Uemura M, Sugimoto N, Naito Y,
Yoshikawa T, Kondo M. Alpha-tocopherol protects against monocyte Mac-1
(CD11b/CD18) expression and Mac-1-dependent adhesion to endothelial cells
induced by oxidized low-density lipoprotein. Biofactors 2000;11:221-33.
247. Sugimoto N, Yoshida N, Yoshikawa T, Nakamuara Y, Ichikawa H, Naito Y,
Kondo M. Effect of vitamin E on aspirin-induced gastric mucosal injury in rats. Dig
248. Nakamura N, Obayashi H, Fujii M, Fukui M, Yoshimori K, Ogata M,
Hasegawa G, Shigeta H, Kitagawa Y, Yoshikawa T, Kondo M, Ohta M, Nishimura
M, Nishinaka T, Nishimura CY. Induction of aldose reductase in cultured human
microvascular endothelial cells by advanced glycation end products. Free Radic Biol
249. Naito Y, Yoshikawa T, Boku Y, Fujii T, Masui Y, Tanaka Y, Fujita N,
Yoshida N, Kondo M. Protective role of intracellular glutathione against nitric
oxide-induced necrosis in rat gastric mucosal cells. Aliment Pharmacol Ther
250. Ichiishi E, Yoshikawa T, Kogawa T, Yoshida N, Kondo M. Possible
paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony
stimulating factor produced by squamous cell carcinoma of the oesophagus. Gut
251. Fujita N, Manabe H, Yoshida N, Matsumoto N, Ochiai J, Masui Y,
Uemura M, Naito Y, Yoshikawa T. Inhibition of angiotensin-converting enzyme
protects endothelial cell against hypoxia/reoxygenation injury. Biofactors
252. Asai K, Kato H, Hirose K, Akaogi K, Kimura S, Mukai S, Inoue M,
Yamamura Y, Sano H, Sugino S, Yoshikawa T, Kondo M. PSK and
OK-432-induced immunomodulation of inducible nitric oxide (NO) synthase gene
expression in mouse peritoneal polymorphonuclear leukocytes and NO-mediated
cytotoxicity. Immunopharmacol Immunotoxicol 2000;22:221-35.
253. Arimoto T, Ichinose T, Yoshikawa T, Shibamoto T. Effect of the natural
antioxidant 2"-O-glycosylisovitexin on superoxide and hydroxyl radical generation.
254. Yoshikawa T, Naito Y, Kondo M. Ginkgo biloba leaf extract: review of
biological actions and clinical applications. Antioxid Redox Signal 1999;1:469-80.
255. Yoshida N, Yoshikawa T, Yamaguchi T, Naito Y, Tanigawa T, Murase H,
Kondo M. A novel water-soluble vitamin E derivative protects against experimental
colitis in rats. Antioxid Redox Signal 1999;1:555-62.
256. Yoshida N, Yoshikawa T, Nakagawa S, Sakamoto K, Nakamura Y, Naito
Y, Kondo M. Effect of shear stress and a stable prostaglandin I2 analogue on
adhesive interactions of colon cancer cells and endothelial cells. Clin Exp Immunol
257. Yoshida N, Yoshikawa T, Nakagawa S, Miyajima T, Nakamura Y, Naito Y,
Tanigawa T, Kondo M. Characteristics of the production of active oxygen species
from adherent and non-adherent neutrophils. Biofactors 1999;9:19-26.
258. Yoshida N, Yoshikawa T, Manabe H, Terasawa Y, Kondo M, Noguchi N,
Niki E. Vitamin E protects against polymorphonuclear leukocyte-dependent
adhesion to endothelial cells. J Leukoc Biol 1999;65:757-63.
259. Toyama K, Yoshikawa K, Yoshida Y, Kondo Y, Tomita S, Takanashi Y,
Ejima Y, Yoshizawa S. A new method for magnetoencephalography: a
three-dimensional magnetometer-spatial filter system. Neuroscience
260. Naito Y, Yoshikawa T, Matsuyama K, Yagi N, Kasai K, Sugimoto N,
Masui Y, Yoshida N, Kondo M. Effect of vitamin E in gastric mucosal injury
induced by ischaemia-reperfusion in nitric oxide-depleted rats. Aliment Pharmacol
261. Kassai K, Yoshikawa T, Yoshida N, Hashiramoto A, Kondo M, Murase H.
Helicobacter pylori water extract induces interleukin-8 production by gastric
epithelial cells. Dig Dis Sci 1999;44:237-42.
262. Ishikawa T, Kobayashi Y, Omoto A, Adachi Y, Nakagawa S, Kaneko T,
Nishida K, Miyamoto Y, Chimori Y, Yoshikawa T, Kondo M. Calcification in
untreated non-Hodgkin's lymphoma of the jejunum. Acta Haematol 1999;102:185-9.
263. Imamoto E, Naito Y, Minami M, Boku Y, Inuma S, Masuyama M,
Taniguchi H, Yoshikawa T, Kondo M. [A case of advanced hepatocellular
carcinoma treated by repeated arterial infusion chemotherapy of 5-FU, LV, CDDP
with an implanted reservoir]. Nippon Shokakibyo Gakkai Zasshi 1999;96:675-9.
264. Hongo H, Takano H, Imai A, Yamaguchi T, Boku Y, Fujii T, Naito Y,
Yoshida N, Yoshikawa T, Kondo M. Pancreatic phospholipase A2 induces bacterial
translocation in rats. Immunopharmacol Immunotoxicol 1999;21:717-26.
265. Ding Y, Matsukawa Y, OhtaniFujita N, Kato D, Dao S, Fujii T, Naito Y,
Yoshikawa T, Sakai T, Rosenthal GA. Growth inhibition of A549 human lung
adenocarcinoma cells by L-canavanine is associated with p21/WAF1 induction. Jpn
266. Capodicasa E, De Bellis F, Pelli MA. Effect of lansoprazole on human
leukocyte function. Immunopharmacol Immunotoxicol 1999;21:357-77.
267. Arimoto T, Yoshikawa T, Takano H, Kohno M. Generation of reactive
oxygen species and 8-hydroxy-2'-deoxyguanosine formation from diesel exhaust
particle components in L1210 cells. Jpn J Pharmacol 1999;80:49-54.
268. Yoshikawa T, Yoshida N, Sugimoto N, Kondo M. [Neutrophil-endothelial
cell interactions in gastrointestinal diseases]. Nippon Rinsho 1998;56:2240-6.
269. Yoshikawa T, Yoshida N, Manabe H, Terasawa Y, Takemura T, Kondo M.
alpha-Tocopherol protects against expression of adhesion molecules on neutrophils
and endothelial cells. Biofactors 1998;7:15-9.
270. Yoshikawa T, Takano H, Kondo M. Role of nitric oxide and reactive
oxygen species in endotoxin shock. Prog Clin Biol Res 1998;397:357-63.
271. Naito Y, Yoshikawa T, Yoshida N, Kondo M. Role of oxygen radical and
lipid peroxidation in indomethacin-induced gastric mucosal injury. Dig Dis Sci
272. Naito Y, Yoshikawa T, Matsuyama K, Yagi N, Arai M, Nakamura Y,
Kaneko T, Yoshida N, Kondo M. Neutrophils, lipid peroxidation, and nitric oxide in
gastric reperfusion injury in rats. Free Radic Biol Med 1998;24:494-502.
273. Naito Y, Yoshikawa T, Iinuma S, Yagi N, Matsuyama K, Boku Y, Fujii T,
Yoshida N, Kondo M, Sasaki S. Rebamipide protects against indomethacin-induced
gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled
study. Dig. Dis. Sci. 1998;43:83S-89S.
274. Morita Y, Yoshikawa T, Takeda S, Matsuyama K, Takahashi S, Yoshida N,
Clemens MG, Kondo M. Involvement of lipid peroxidation in free fatty
acid-induced isolated rat pancreatic acinar cell injury. Pancreas 1998;17:383-9.
275. Makino M, Takanashi Y, Iwamoto K, Yoshikawa K, Ohshima H,
Nakajima K, Hayashi K, Hayashi R, Endo K. [Auditory evoked magnetic fields in
patients of pure word deafness]. No To Shinkei 1998;50:51-5.
276. Iinuma S, Yoshikawa T, Yoshida N, Naito Y, Kondo M. Role of active
oxygen species and lipid peroxidation in mepirizole-induced duodenal ulcers in rats.
277. Yoshikawa T, Yamaguchi T, Yoshida N, Yamamoto H, Kitazumi S,
Takahashi S, Naito Y, Kondo M. Effect of Z-103 on TNB-induced colitis in rats.
278. Yoshikawa T, Takano H, Yamamoto H, Nakahashi Y, Yamaguchi T,
Arimoto T, Kondo M. Role of superoxide and nitric oxide in platelet-activating
factor-induced acute lung injury, hypotension, and mortality in rats. Crit Care Med
279. Yoshikawa T, Naito Y, Masui K, Fujii T, Boku Y, Nakagawa S, Yoshida N,
Kondo M. Free radical-scavenging activity of Crassostera gigas extract (JCOE).
280. Yoshikawa T, Minamiyama Y, Ichikawa H, Takahashi S, Naito Y, Kondo
M. Role of lipid peroxidation and antioxidants in gastric mucosal injury induced by
the hypoxanthine-xanthine oxidase system in rats. Free Radic Biol Med
281. Yoshikawa T, Kondo M. [Measurement of reactive oxygen species
generated from neutrophils]. Nippon Rinsho 1997;55 Suppl 1:210-5.
282. Yoshikawa K, Iwamoto K, Sugimoto E, Takanashi Y, Nakajima K. [A case
of porencephaly with mirror movements: pathophysiological investigation by using
long-latency long-loop reflex and dipole tracing method]. Rinsho Shinkeigaku
283. Yoshida N, Yoshikawa T, Nakamura Y, Takenaka S, Sakamoto K, Manabe
H, Nakagawa S, Kondo M. Methylprednisolone inhibits neutrophil-endothelial cell
interactions induced by interleukin-1beta under flow conditions. Life Sci
284. Tenjin H, Yasukochi K, Nakahara Y, Higuchi T, Naruse S, Ueda S,
Horikawa Y, Furuya S, Yoshikawa K. Preoperative detection of the composition of
atherosclerotic plaque in the carotid artery using ultrasonography and magnetic
resonance imaging. Neurol Med Chir (Tokyo) 1997;37:505-10; discussion 510-1.
285. Takano H, Yoshikawa T, Yamaguchi T, Hongo H, Fujii T, Boku Y, Yoshida
N, Yamamoto H, Nakahashi Y, Yanagisawa R, Kondo M. Effects of aminoguanidine
on systemic inflammatory response syndrome induced by platelet activating factor
and by lipopolysaccharide in rats. Eur J Pharmacol 1997;323:107-10.
286. Sha S, Minakuchi K, Higaki N, Sato K, Ohtsuki K, Kurata A, Yoshikawa
H, Kotaru M, Masumura T, Ichihara K, Tanaka K. Purification and characterization
of glutaredoxin (thioltransferase) from rice (Oryza sativa L.). J Biochem (Tokyo)
287. Sakamoto S, Okanoue T, Itoh Y, Sakamoto K, Nishioji K, Nakagawa Y,
Yoshida N, Yoshikawa T, Kashima K. Intercellular adhesion molecule-1 and CD18
are involved in neutrophil adhesion and its cytotoxicity to cultured sinusoidal
endothelial cells in rats. Hepatology 1997;26:658-63.
288. Naito Y, Yoshikawa T, Matsuyama K, Yagi N, Nakamura Y, Nishimura S,
Kaneko T, Yoshida N, Kondo M. Effect of the histamine H2-receptor antagonist
(+/-)-(E)-1-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-3'-[2-[[[5-methylamino )
methyl-2-furyl] methyl]thio]ethyl]-2"-(methylsulfonyl)guanidine on acute gastric
mucosal injury in rats and its free-radical scavenging activities.
Arzneimittelforschung 1997;47:845-8.
289. Naito Y, Yoshikawa T, Fujii T, Boku Y, Yagi N, Dao S, Yoshida N, Kondo
M, Matsui H, Ohtani-Fujita N, Sakai T. Monochloramine-induced cell growth
inhibition and apoptosis in a rat gastric mucosal cell line. J Clin Gastroenterol
290. Kokura S, Yoshikawa T, Naito Y, Ichikawa H, Takano H, Takahashi S,
Tomii T, Yoshida N, Kondo M. Effects of rebamipide, a novel anti-ulcer agent, on
gastric mucosal injury induced by platelet-activating factor in rats. Dig Dis Sci
291. Kokura S, Yoshikawa T, Kaneko T, Iinuma S, Nishimura S, Matsuyama K,
Naito Y, Yoshida N, Kondo M. Efficacy of hyperthermia and polyunsaturated fatty
acids on experimental carcinoma. Cancer Res 1997;57:2200-2.
292. Yoshikawa T, Naito Y, Yoshida N. [Pathogenesis and therapy of
non-steroidal anti-inflammatory drug (NSAID)-induced gastric mucosal injury].
Nippon Seikeigeka Gakkai Zasshi 1996;70:269-73.
293. Yoshida N, Yoshikawa T, Iinuma S, Arai M, Takenaka S, Sakamoto K,
Miyajima T, Nakamura Y, Yagi N, Naito Y, Mukai F, Kondo M. Rebamipide protects
against activation of neutrophils by Helicobacter pylori. Dig Dis Sci
294. Naito Y, Yoshikawa T, Iinuma S, Miyazaki R, Yagi N, Yoshida N, Osumi
T, Hirao Y, Kondo M. Local gastric and serum concentrations of rebamipide
following oral administration to patients with chronic gastritis.
Arzneimittelforschung 1996;46:698-700.
295. Kokura S, Yoshikawa T, Tainaka K, Kaneko T, Iinuma S, Nishimura S,
Matuyama K, Kondo M. Anti-tumor effects of hyperthermia plus granulocyte
colony-stimulating factor. Jpn J Cancer Res 1996;87:862-6.
296. Arimoto T, Yoshikawa T, Komori Y, Kumagai Y. Inhibition of constitutive
nitric oxide synthase by benexate. Life Sci 1996;59:953-9.
297. Yoshikawa T, Takano H, Yoshida N, Kondo M. Simultaneous
intraperitoneal administration of OK-432 and serum enhances superoxide generation
from migrated polymorphonuclear leukocytes, with special emphasis on the role of
complements. Immunopharmacol Immunotoxicol 1995;17:265-82.
298. Yoshikawa T, Kokura S, Tainaka K, Naito Y, Kondo M. A novel cancer
therapy based on oxygen radicals. Cancer Res 1995;55:1617-20.
299. Yoshida N, Yoshikawa T, Nakamura Y, Arai M, Matsuyama K, Iinuma S,
Yagi N, Naito Y, Miyasaka M, Kondo M. Role of neutrophil-mediated inflammation
in aspirin-induced gastric mucosal injury. Dig Dis Sci 1995;40:2300-4.
300. Yoshida N, Yoshikawa T, Nakamura Y, Arai M, Matsuyama K, Iinuma S,
Nishimura S, Kondo M. Role of neutrophil-endothelial cell interactions in gastric
mucosal injury induced by aspirin. J Clin Gastroenterol 1995;21 Suppl 1:S73-7.
301. Suzuki M, Nakamura M, Mori M, Miura S, Tsuchiya M, Ishii H.
Lansoprazole inhibits oxygen-derived free radical production from neutrophils
activated by Helicobacter pylori. J Clin Gastroenterol 1995;20 Suppl 2:S93-6.
302. Naito Y, Yoshikawa T, Yoneta T, Yagi N, Matsuyama K, Arai M,
Tanigawa T, Kondo M. A new gastric ulcer model in rats produced by ferrous iron
and ascorbic acid injection. Digestion 1995;56:472-8.
303. Naito Y, Yoshikawa T, Tanigawa T, Sakurai K, Yamasaki K, Uchida M,
Kondo M. Hydroxyl radical scavenging by rebamipide and related compounds:
electron paramagnetic resonance study. Free Radic Biol Med 1995;18:117-23.
304. Naito Y, Yoshikawa T, Matsuyama K, Yagi N, Arai M, Nakamura Y,
Nishimura S, Yoshida N, Kondo M. Effects of oxygen radical scavengers on the
quality of gastric ulcer healing in rats. J Clin Gastroenterol 1995;21 Suppl 1:S82-6.
305. Naito Y, Yoshikawa T, Matsuyama K, Yagi N, Arai M, Nakamura Y,
Kaneko T, Yoshida N, Kondo M. Effect of a novel histamine H2 receptor antagonist,
IT-066, on acute gastric injury induced by ischemia-reperfusion in rats, and its
antioxidative properties. Eur J Pharmacol 1995;294:47-54.
306. Naito Y, Yoshikawa T, Matsuyama K, Nishimura S, Yagi N, Kondo M.
Effects of free radical scavengers on indomethacin-induced aggravation of gastric
ulcer in rats. Dig Dis Sci 1995;40:2019-21.
307. Matsuki M, Hashimoto K, Yoshikawa K, Yasuno H, Yamanishi K.
Epidermolysis bullosa simplex (Weber-Cockayne) associated with a novel missense
mutation of Asp328 to Val in Linker 12 domain of keratin 5. Hum Mol Genet
308. Kondo M, Yoshikawa T, Takano H. [Free radical and allergy]. Arerugi
309. Kondo M, Itani K, Yoshikawa T, Tanaka Y, Watanabe N, Hiraoka M,
Noguchi M, Miura K. [A prospective randomized clinical trial comparing
intra-arterial chemotherapy alone and when combined with hyperthermia for
metastatic liver cancer]. Gan To Kagaku Ryoho 1995;22:1807-11.
310. Fujita N, Yoshikawa T, Uemura M, Tsukuda C, Matsumoto N, Shimada M,
Arai M, Yagi N, Naito Y, Kondo M. [A case of juvenile hepatocellular carcinoma
arising from normal liver]. Nippon Shokakibyo Gakkai Zasshi 1995;92:1092-7.
311. Yoshikawa T, Takano H, Takahashi S, Ichikawa H, Kondo M. Changes in
tissue antioxidant enzyme activities and lipid peroxides in endotoxin-induced
multiple organ failure. Circ Shock 1994;42:53-8.
312. Yoshikawa T, Naito Y. Reperfusion injury in gastric mucosa. Ann N Y
313. Yoshikawa T, Minamiyama Y, Naito Y, Kondo M. Antioxidant properties
of bromocriptine, a dopamine agonist. J Neurochem 1994;62:1034-8.
314. Yoshikawa T, Kokura S, Oyamada H, Iinuma S, Nishimura S, Kaneko T,
Naito Y, Kondo M. Antitumor effect of ischemia-reperfusion injury induced by
transient embolization. Cancer Res 1994;54:5033-5.
315. Tanigawa T, Yoshikawa T, Takahashi S, Naito Y, Kondo M. Spin trapping
of superoxide in aqueous solutions of fresh and aged cigarette smoke. Free Radic
316. Minamiyama Y, Yoshikawa T, Tanigawa T, Takahashi S, Naito Y,
Ichikawa H, Kondo M. Antioxidative effects of a processed grain food. J Nutr Sci
317. Arai M, Yoshikawa T, Kondo M. [Enterocolitis]. Nippon Rinsho
318. Yoshikawa T, Nakamura S, Takahashi S, Naito Y, Kondo M. Effect of
sofalcone on gastric mucosal injury induced by ischemia-reperfusion and its
antioxidant properties. J Clin Gastroenterol 1993;17 Suppl 1:S111-5.
319. Yoshikawa T, Naito Y, Tanigawa T, Kondo M. Free radical scavenging
activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance.
Arzneimittelforschung 1993;43:363-6.
320. Yoshikawa T, Naito Y, Nakamura S, Nishimura S, Kaneko T, Iinuma S,
Takahashi S, Kondo M, Yamasaki K. Effect of rebamipide on lipid peroxidation and
gastric mucosal injury induced by indometacin in rats. Arzneimittelforschung
321. Yoshikawa T, Naito Y, Kondo M. Antioxidant therapy in digestive
diseases. J Nutr Sci Vitaminol (Tokyo) 1993;39 Suppl:S35-41.
322. Yoshikawa T, Naito Y, Kishi A, Tomii T, Kaneko T, Iinuma S, Ichikawa H,
Yasuda M, Takahashi S, Kondo M. Role of active oxygen, lipid peroxidation, and
antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin
323. Yoshikawa T, Kokura S, Tainaka K, Itani K, Oyamada H, Kaneko T, Naito
Y, Kondo M. The role of active oxygen species and lipid peroxidation in the
antitumor effect of hyperthermia. Cancer Res 1993;53:2326-9.
324. Yoshikawa T, Itani K, Kokura S, Oyamada H, Kondo M. [Effect of
intra-arterial chemotherapy combined with degradable starch microspheres against
liver cancer--a study by experimental VX2 liver tumor model]. Gan To Kagaku
325. Yoshikawa T. Free radicals and their scavengers in Parkinson's disease.
326. Tanigawa T, Yoshikawa T, Minamiyama Y, Takahashi S, Ando T, Naito Y,
Morita Y, Kondo M. Detection of free radicals in the blood of animals using
extracorporeal circulation. Free Radic Res Commun 1993;19 Suppl 1:S171-6.
327. Takahashi S, Yoshikawa T, Naito Y, Minamiyama Y, Tanigawa T, Kondo
M. Antioxidant properties of antiulcer Kampo medicines. Free Radic Res Commun
328. Naito Y, Yoshikawa T, Kaneko T, Iinuma S, Nishimura S, Takahashi S,
Kondo M. Role of oxygen radicals in indomethacin-induced gastric mucosal
microvascular injury in rats. J Clin Gastroenterol 1993;17 Suppl 1:S99-103.
329. Yoshikawa T, Takano H, Naito Y, Oyamada H, Ueda S, Kondo M.
Augmentative effects of tumor necrosis factor-alpha (human, natural type) on
polymorphonuclear leukocyte-derived superoxide generation induced by various
stimulants. Int J Immunopharmacol 1992;14:1391-8.
330. Yoshikawa T, Takahashi S, Naito Y, Ueda S, Tanigawa T, Yoshida N,
Kondo M. Effects of a platelet-activating factor antagonist, CV-6209, on gastric
mucosal lesions induced by ischemia-reperfusion. Lipids 1992;27:1058-60.
331. Yoshikawa T, Takahashi S, Naito Y, Kondo M. Antioxidants in gastric
mucosal injury. J Nutr Sci Vitaminol (Tokyo) 1992;Spec No:556-9.
332. Yoshikawa T, Takahashi S, Kondo M. Possible role of free radicals in the
chronic inflammation of the gut. Exs 1992;62:353-8.
333. Yoshikawa T, Naito Y, Ueda S, Ichikawa H, Takahashi S, Yasuda M,
Kondo M. Ischemia-reperfusion injury and free radical involvement in gastric
mucosal disorders. Adv Exp Med Biol 1992;316:231-8.
334. Yoshikawa T, Ichikawa H, Naito Y, Kondo M. Role of leukotrienes in
gastric mucosal injury induced by ischemia-reperfusion in rats. J Clin Gastroenterol
335. Oda T, Nakai I, Mituo M, Yamagishi H, Oka T, Yoshikawa T. Role of
oxygen radicals and synergistic effect of superoxide dismutase and catalase on
ischemia-reperfusion injury of the rat pancreas. Transplant Proc 1992;24:797-8.
336. Naito Y, Yoshikawa T, Ando T, Kishi A, Ueda S, Oyamada H, Kondo M.
Changes in superoxide dismutase activity in the gastric mucosa of peptic ulcer
patients. J Clin Gastroenterol 1992;14 Suppl 1:S131-4.
337. Kokura S, Yoshikawa T, Kaneko T, Iinuma S, Oyamada H, Tainaka K,
Itani K, Kondo M. [Role of polymorphonuclear leukocytes (PMN) and active
oxygen species in hyperthermia--antitumor effect of hyperthermia combined with
rhG-CSF]. Gan To Kagaku Ryoho 1992;19:1655-8.
338. Kawai T, Wada Y, Kawachi H, Ohga K, Oka T, Yasuda M, Yoshikawa T.
[Metabolism of Ca2+ in myocytes and peroxidation products in
ischemia-reperfusion injury under extracorporeal circulation]. Nippon Kyobu Geka
339. Kaneko T, Yoshikawa T, Kokura S, Nishimura S, Naito Y, Takemura T,
Tainaka K, Kondo M. [Role of polymorphonuclear leukocytes (PMN) and active
oxygen species in hyperthermia--enhancing effect of G-CSF on superoxide
generation from PMN]. Gan To Kagaku Ryoho 1992;19:1659-62.
340. Ichitani Y, Okaichi H, Yoshikawa T, Ibata Y. Learning behaviour in
chronic vitamin E-deficient and -supplemented rats: radial arm maze learning and
passive avoidance response. Behav Brain Res 1992;51:157-64.
341. Fukui M, Kogawa T, Tawara Y, Yamamoto H, Matsuyama K, Tsujigiwa M,
Yoshikawa T, Sugino S, Kondo M. [A case report of huge liver cyst with edema of
lower extremities]. Nippon Shokakibyo Gakkai Zasshi 1992;89:2798-803.
342. Yoshikawa T, Yasuda M, Ueda S, Naito Y, Tanigawa T, Oyamada H,
Kondo M. Vitamin E in gastric mucosal injury induced by ischemia-reperfusion. Am
343. Yoshikawa T, Naito Y, Tanigawa T, Yoneta T, Yasuda M, Ueda S,
Oyamada H, Kondo M. Effect of zinc-carnosine chelate compound (Z-103), a novel
antioxidant, on acute gastric mucosal injury induced by ischemia-reperfusion in rats.
Free Radic Res Commun 1991;14:289-96.
344. Yoshikawa T, Naito Y, Tanigawa T, Yoneta T, Kondo M. The antioxidant
properties of a novel zinc-carnosine chelate compound,
N-(3-aminopropionyl)-L-histidinato zinc. Biochim Biophys Acta 1991;1115:15-22.
345. Takahashi S, Yoshikawa T, Naito Y, Tanigawa T, Yoshida N, Kondo M.
Role of platelet-activating factor (PAF) in superoxide production by human
polymorphonuclear leukocytes. Lipids 1991;26:1227-30.
346. Kondo M, Itani K, Yoshikawa T, Oyamada H, Ichikawa H, Kokura S,
Tainaka K, Sugino S. [Chemoembolization with degradable starch microspheres for
liver metastases of colorectal cancer]. Gan To Kagaku Ryoho 1991;18:535-40.
347. Kokura S, Yoshikawa T, Takahashi S, Oyamada H, Sugino S, Kondo M.
[Role of oxygen species and lipid peroxidation for anti-tumor effect of intra-arterial
injection with degradable starch microspheres]. Gan To Kagaku Ryoho
348. Kawai T, Wada Y, Nishiyama K, Kanki Y, Ohga K, Oka T, Yasuda M,
Yoshikawa T. [Usefulness of ulinastatin as a radical scavenger for protection of
reperfusion injury after myocardial ischemia in open heart surgery]. Nippon Kyobu
349. Yoshikawa T, Ueda S, Takahashi S, Naito Y, Oyamada H, Morita Y,
Tanigawa T, Takemura T, Sugino S, Kondo M. [Role of free radicals and lipid
peroxidation in gastric mucosal injury induced by ischemia-reperfusion in rats].
Nippon Shokakibyo Gakkai Zasshi 1990;87:8-15.
350. Yoshikawa T, Takeda S, Naito Y, Kondo M. Protective effects of
ONO-3307, a new synthetic protease inhibitor against experimental disseminated
intravascular coagulation in rats. Thromb Res 1990;60:1-7.
351. Yoshikawa T, Oyamada H, Ichikawa H, Naito Y, Ueda S, Tainaka K,
Takemura T, Tanigawa T, Sugino S, Kondo M. [Role of active oxygen species and
lipid peroxidation in liver injury induced by ischemia-reperfusion]. Nippon
Shokakibyo Gakkai Zasshi 1990;87:199-205.
352. Yoshikawa T, Naito Y, Ueda S, Takahashi S, Oyamada H, Yoneta T,
Sugino S, Kondo M. Ischemia-reperfusion injury and free radical involvement in
gastric mucosal disorders. Adv Exp Med Biol 1990;264:401-10.
353. Yoshikawa T, Naito Y, Ueda S, Oyamada H, Takemura T, Yoshida N,
Sugino S, Kondo M. Role of oxygen-derived free radicals in the pathogenesis of
gastric mucosal lesions in rats. J Clin Gastroenterol 1990;12 Suppl 1:S65-71.
354. Yoshikawa T, Naito Y, Oyamada H, Ueda S, Tanigawa T, Takemura T,
Sugino S, Kondo M. Scavenging effects of Aspalathus linealis (Rooibos tea) on
active oxygen species. Adv Exp Med Biol 1990;264:171-4.
355. Yoshikawa T, Kondo M. [Free radicals in digestive diseases]. Nippon
Ronen Igakkai Zasshi 1990;27:155-60.
356. Yoshikawa T, Kondo M. [Multiple organ failure and free radicals].
Nippon Naika Gakkai Zasshi 1990;79:1239-43.
357. Yoshikawa T, Kondo M. Free radicals in multiple organ failure. Jpn J Med
358. Yoshikawa H, Furuki J, Takahashi Y, Morioka H, Yoshida Y.
Freeze-fracture study of the bloodstream form of Trypanosoma brucei gambiense. J
359. Ueda S, Yoshikawa T, Takahashi S, Naito Y, Oyamada H, Takemura T,
Morita Y, Tanigawa T, Sugino S, Kondo M. Protection by seleno-organic compound,
Ebselen, against acute gastric mucosal injury induced by ischemia-reperfusion in
rats. Adv Exp Med Biol 1990;264:187-90.
360. Tanigawa T, Yoshikawa T, Naito Y, Yoneta T, Ueda S, Oyamada H,
Takemura T, Morita Y, Tainaka K, Yoshida N, et al. Antioxidative action of
zinc-carnosine compound Z-103. Adv Exp Med Biol 1990;264:223-8.
361. Takemura T, Yoshikawa T, Naito Y, Ueda S, Tanigawa T, Sugino S,
Kondo M. Role of xanthine-xanthine oxidase systems and polymorphonuclear
leukocytes in lipid peroxidation in compound 48/80-induced gastric mucosal injury
in rats. Adv Exp Med Biol 1990;264:415-8.
362. Naito Y, Yoshikawa T, Tanigawa T, Yoneta T, Ueda S, Oyamada H,
Takemura T, Sugino S, Kondo M. Zinc-carnosine chelate compound (Z-103)
attenuates acute gastric mucosal injury induced by ischemia-reperfusion in rats. Adv
363. Kokura S, Yoshikawa T, Kishi A, Tomii T, Tsujigiwa M, Yasuda M,
Ichikawa H, Takano H, Takahashi S, Naito Y, et al. [Role of oxygen-derived free
radicals for antitumor effects of intra-arterial injection with adriamycin]. Gan To
364. Hiraoka N, Yoshikawa T, Kondo M, Nishioka H, Goto I, Fukuoka J,
Ohsawa A, Yokoh S. [Reduction in leukocyte elastase levels in patients with sepsis
by administration of urinastatin]. Masui 1990;39:367-71.
365. Arizono N, Shiota T, Yamada M, Matsumoto Y, Yoshikawa H, Matsuda S,
Tegoshi T. Bromodeoxyuridine labeling studies on the proliferation of intestinal
mucosal mast cells in normal and athymic rats. Apmis 1990;98:369-76.
366. Yoshikawa T, Ueda S, Naito Y, Takahashi S, Oyamada H, Morita Y,
Yoneta T, Kondo M. Role of oxygen-derived free radicals in gastric mucosal injury
induced by ischemia or ischemia-reperfusion in rats. Free Radic Res Commun
367. Yoshikawa H, Yoshida Y. Ultrastructure of Pneumocystis carinii: a
freeze-fracture study. J Protozool 1989;36:51S-52S.
368. Yoshikawa H, Yamada M, Matsumoto Y, Yoshida Y. Variations in egg size
of Trichuris trichiura. Parasitol Res 1989;75:649-54.
369. Yoshikawa H, Tegoshi T, Yoshida Y. Detection of surface carbohydrates of
Pneumocystis carinii. J Protozool 1989;36:63S-64S.
370. Yoshida Y, Shiota T, Yamada M, Yoshikawa H, Tegoshi T, Ikai T, Ogino K.
The present status of Pneumocystis carinii pneumonia in Japan with special
reference to AIDS. J Protozool 1989;36:78S-80S.
371. Yoshida N, Yoshikawa T, Ando T, Naito Y, Oyamada H, Takemura T,
Tanigawa T, Sugino S, Kondo M. Pathogenesis of platelet-activating factor-induced
gastric mucosal damage in rats. Scand J Gastroenterol Suppl 1989;162:210-4.
372. Ueda S, Yoshikawa T, Takahashi S, Ichikawa H, Yasuda M, Oyamada H,
Tanigawa T, Sugino S, Kondo M. Role of free radicals and lipid peroxidation in
gastric mucosal injury induced by ischemia-reperfusion in rats. Scand J
373. Takemura T, Yoshikawa T, Yoshida N, Takano H, Tasaki N, Naito Y, Ueda
S, Sugino S, Kondo M. Role of lipid peroxidation and oxygen radicals in compound
48/80-induced gastric mucosal injury in rats. Scand J Gastroenterol Suppl
374. Oyamada H, Yoshikawa T, Itani K, Ichikawa H, Tainaka K, Seto O,
Sugino S, Kondo M. [Chemo-embolization using degradable starch microspheres
and regional hyperthermia in unresectable hepatocellular carcinoma]. Gan To
375. Matsuda S, Urata Y, Shiota T, Yamada M, Yoshikawa H, Tegoshi T, Okada
M, Nakamura H, Kitaoka T, Ashihara T, et al. Disseminated infection of
Pneumocystis carinii in a patient with the acquired immunodeficiency syndrome.
Virchows Arch A Pathol Anat Histopathol 1989;414:523-7.
376. Kondo M, Yoshikawa T. [Role of free radicals in the treatment of cancer].
Gan To Kagaku Ryoho 1989;16:3655-61.
377. Itani K, Yoshikawa T, Oyamada H, Takano H, Ichikawa H, Tainaka K,
Sugino S, Kondo M. [Chemoembolization with degradable starch microspheres for
liver metastases in colorectal cancer]. Gan To Kagaku Ryoho 1989;16:2897-900.
378. Yoshikawa T, Yoshida N, Miyagawa H, Tanigawa T, Takemura T, Morita
Y, Sugino S, Kondo M. Role of oxygen radicals in endotoxin shock and
disseminated intravascular coagulation. Basic Life Sci 1988;49:933-40.
379. Yoshikawa T, Oyamada H, Itani K, Tainaka K, Seto O, Sugino S, Kondo
M. [Chemoembolization and regional hyperthermia with degradable starch
microspheres in the treatment of malignant hepatic tumors]. Gan To Kagaku Ryoho
380. Yoshikawa T, Giamalva DH, Flory W, Ruhr LP, Church DF, Pryor WA.
Toxicity of aromatic hydrocarbons. VII. Hepatotoxicity of 9-nitrophenanthrene, and
protection against it by beta-naphthoflavone. Biochem Int 1988;16:935-40.
381. Yoshikawa T, Flory W, Giamalva DH, Ruhr LP, Church DF, Pryor WA.
Toxicity of polycyclic aromatic hydrocarbons. VI. Effects of 1-nitropyrene on serum
enzyme levels in rats, and protection against it by beta-naphthoflavone and dimethyl
sulfoxide. Biochem Int 1988;16:929-34.
382. Yoshikawa H, Yamada M, Yoshida Y. Freeze-fracture study of the
trophozoite and the cyst of Entamoeba histolytica. J Protozool 1988;35:268-73.
383. Yoshikawa H, Yamada M, Yoshida Y. Freeze-fracture study of Blastocystis
384. Yoshikawa H, Morioka H, Yoshida Y. Ultrastructural detection of
carbohydrates in the pellicle of Pneumocystis carinii. Parasitol Res 1988;74:537-43.
385. Naito Y, Yoshikawa T, Oyamada H, Tainaka K, Morita Y, Kogawa T,
Sugino S, Kondo M. Esophageal candidiasis. Gastroenterol Jpn 1988;23:363-70.
386. Itani K, Yoshikawa T, Tainaka K, Oyamada Y, Sugino S, Kondo M, Seto
O. [Effects of hyperthermia combined with chemoembolization using degradable
starch microspheres in the treatment of hepatocellular carcinoma]. Gan To Kagaku
387. Itani K, Yoshikawa T, Oyamada Y, Tainaka K, Sugino S, Kondo M.
[Chemoembolization with degradable starch microspheres in metastatic liver
cancer]. Gan To Kagaku Ryoho 1988;15:2606-10.
388. Yoshikawa T, Giamalva DH, Flory W, Ruhr LP, Church DF, Pryor WA.
Toxicity of polycyclic aromatic hydrocarbons. IV. Effects of diphenaldehyde, a
major product of ozonized phenanthrene, in rats. Biochem Int 1987;15:139-46.
389. Yoshikawa T, Flory W, Giamalva DH, Ruhr LP, Church DF, Pryor WA.
Toxicity of polycyclic aromatic hydrocarbons. V. Protective effect of
beta-naphthoflavone against hepatotoxicity induced by diphenaldehyde in rats.
390. Yoshikawa H, Yoshida Y. Freeze-fracture studies on Pneumocystis carinii.
III. Fine structure of the precyst and the cyst. Parasitol Res 1987;74:36-42.
391. Yoshikawa H, Yoshida Y. Localization of silver deposits on Pneumocystis
carinii treated with Gomori's methenamine silver nitrate stain. Zentralbl Bakteriol
392. Yoshikawa H, Tegoshi T, Yoshida Y. Detection of surface carbohydrates
on Pneumocystis carinii by fluorescein-conjugated lectins. Parasitol Res
393. Yamada M, Yoshikawa H, Tegoshi T, Matsumoto Y, Yoshikawa T, Shiota
T, Yoshida Y. Light microscopical study of Blastocystis spp. in monkeys and fowls.
Rekommenderad användning Massera in 1/8 till 1/4 tesked av krämen (1/4 tesked har samma storlek som en kikärta ungefär och 1/8tesked motsvarar storleken på en vanlig ärta), 1-2 gånger om dagen, där du har lite tunnare hud, t.ex. halsen,bröstet, magen, insidan av armarna och låren, handflatorna eller fotsulorna. Variera ställe frångång till gång. Använd efter bad eller dusch, in
Stiche gegen Hitzewallungen Patientinnen mit Brustkrebs haben häufig mit klimakterischen Symptomen zu kämpfen. Da die Therapie der Wahl (Venlafaxin) risikobehaftet und nebenwirkungsreich ist, hat eine randomisierte US-Studie diese gegen Akupunktur getestet. Antiöstrogenbehandlungen (Tamoxifen, Raloxifen), wie sie im Rahmen der konventionellen Brustkrebstherapie häufig verschrieben