Impotentie brengt een constant ongemak met zich mee, net als fysieke en psychologische problemen in uw leven cialis kopen terwijl generieke medicijnen al bewezen en geperfectioneerd zijn
Microsoft word - 04_ijpsn-1-19-13-hetal-accepted-corrected
Int J Pharm Sci Nanotech Vol 6;
December 2013 (extra issue)
International Journal of Pharmaceutical Sciences and Nanotechnology
Volume 6 •
Issue 4 • December 2013 (extra issue)
Development of Colon Delivery Tablets of Albendazole using pH-Dependent Polymers
Kansagara Hetal*, Bhagat Shreel and Singh Sudarshan
Department of Pharmaceutics, H.N. Shukla institute of Pharmacy, Affiliate of Gujarat Technical University, Near Lalpari Lake, Amargadh (Bhichari)-360001, Gugarat, India.
Received January 19, 2013; accepted August 14, 2013
Albendazole is a banzimidazole derivative with broad with pH dependent polymers and plasticizers. The spectrum anthelmentic activity and excellent tolerability.
prepared tablets were evaluated for hardness, friability,
Albendazole was selected for colon delivery because the
drug content and in vitro dissolution. Among all
colon is the major site of residence for several types of
formulations, Eudragit S100 coated tablets showed the
worms and only a very small amount of drug reaches the
best outcome to protect the drug in stomach environment
colon after oral administration. The objective of this work
as compare to CAP. Tablets coated with 8% Eudragit S100
was to deliver Albendazole to colon by coating it with
showed 98.08% drug release within 12 hr. These findings
various pH dependent polymers and plasticizers. The indicate the potential viability using pH dependent formulations were prepared with lactose monohydrate by
polymers for colon specific drug delivery.
wet granulation method using Starch paste and coated
Albendazole; pH dependent polymers; Eudragit S100; CAP.
targeting. However, colonic transit time can last for up to
78 hr, thereby allowing the absorption of even drugs of
Albendazole is a banzimidazole derivative with broad
low permeability (Chauhan et al., 2010).
spectrum anthelmentic activity and excellent tolerability.
The goal of this study was to develop albendazole
Albendazole was selected for colon delivery because the colon targeted tablets using pH dependent polymers and
colon is the major site of residence for several types of plasticizers which target the delivery within the colon.
worms and only a very small amount of drug reaches the colon after oral administration (Khokra et al., 2012).
Targeting of drugs to the large intestine has number of
important implication in the field of pharmacotherapy.
Materials and Methods
Various approaches have been used for oral delivery of
Albendazole was procured as a gift sample from
drugs to colon, which include pH-dependent systems, Mepro Labs, Surendranagar, India. Sodium
time-dependent systems and systems which are Carboxymethyl Cellulose, Lactose Monohydrate,
bacterially triggered in the colon. Among these Crosscarmellose Sodium, Magnesium Stearate, Talc and
strategies, systems relying on the metabolic activity of Starch were used from college. Eudragit S100 (Evonik
colonic micro flora are not significant. There are many industry), CAP (cellulose acetyl phthalate, Deep coat
problem related to enzymatic degradation like expensive
polymers), diethyl phthalate, acetone and isopropyl
raw material, rare source of natural polymer, microbial alcohol are of standard quality.
contamination of natural polymer (Chauhan et al., 2010).
Time-controlled release systems such as sustained or
Preparation of Core Tablets
delayed-release dosage forms are very promising due to the potentially large variation in gastric emptying time
Tablets were prepared by conventional wet granulation
for dosage form in human. In this approach the colon method. The various excipients used were listed in Table
arrival time of dosage forms cannot be accurately 1. Ingredients except glidants and lubricant were predicted resulting in poor colonical availability. The pH-
thoroughly mixed and passed through sieve no. 60.
dependent systems are more preferable for colon delivery
Granulation was done with a 5% starch paste. The wet
systems. Various polymers are available like Eudragit mass was passed through sieve no. 12 and dried at 50°C ES, Eudragit FS, Eudragit S, CAP, HPMC Phthalate, for 1 hr. The dried granules were lubricated with
and Shellac (Chauhan et al., 2010). Drugs can be magnesium stearate and talc, then compressed into delivered with pH-dependent system to colon by specific tablets using single station tablet punch machine.
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