Pediatric Allergic Rhinitis:
Antihistamine Selection

As the most common of mediated inflammation of the are not serious and do not endan- Allergic Rhinitis
and Children
19 years.5,8 As with adults, the im-pact of AR in children extends be-yond the immediate symptomsand has a profound effect on chil-dren’s QoL, the extent of which Allergy/Asthma Associates, Mission Viejo, California.
the severity of disease.9 Trouble-some, repeated nose blowing, fa- This paper was supported by an educational grant from Aventis Pharmaceuticals.
Reprint requests and correspondence to: William E. Berger, MD, Allergy/Asthma Associates,
27800 Medical Center Road, 244 Mission Viejo, CA 92691.
2005 Westminster Publications, Inc., 708 Glen Cove Avenue, Glen Head, NY 11545, U.S.A.
A n t i h i s t a m i n e s a n d A l l e r g i c R h i n i t i s cost, availability, and advertisingplay a significant role in deter- mining which antihistamine achild receives.
Loratadine rapidly disintegrating tablets avoiding the adverse events (AEs)obser ved with older agents. Al-though these agents are credited Cetirizine (Zyrtec®) tablets (5 mg, 10 mg) Cetirizine (Zyrtec®) syrup (5 mL [2.5mg]) gous. Therefore, each agentshould be judged separately interms of relative efficacy and 60 mg (30 mg BID) (children 6–11 yrof age) safety. To date, three oral newer-generation antihistamines areavailable for use in children in the gra® [Aventis Pharm.], indicatedfor use in children aged 6 yearsand older), loratadine (Claritin®[Schering-Plough], 2 years orolder) and cetirizine (Zyrtec® Clinical Efficacy and
Safety of Newer-
Antihistamines in
rated ‘good’ or ‘excellent’ in 82% A n t i h i s t a m i n e s a n d A l l e r g i c R h i n i t i s A n t i h i s t a m i n e s a n d A l l e r g i c R h i n i t i s Conclusions
with trials of these antihistamines.
a fast onset of action is desirable.
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blind, placebo controlled study. J Al- of present clinical experience. Drug lergy Clin Immunol. 2003;111:1244- J Allergy Clin Immunol. 2001;108(1 22. Lutsky BN, Klose P, Melon J, Krupp P.
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Pediatrics. 2004;113:e116-e121.
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the United States in 1990. Ann Allergy. study. Pediatr Asthma Allergy Immunol. gic rhinitis. J Allergy Clin Immunol. children. In: Simons FER, ed: Hista- 25. Masi M, Candiani R, van de Venne H.
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38. Wober W, Diez Crespo CD, Bahre M.
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