Impotentie brengt een constant ongemak met zich mee, net als fysieke en psychologische problemen in uw leven cialis kopen terwijl generieke medicijnen al bewezen en geperfectioneerd zijn
I N T E R N A L M E D I C I N E N E W S • S e p t e m b e r 1 5 , 2 0 0 6
Risedronate Gains Approval for Male Osteoporosis
B Y N A N C Y W A L S H
porosis,” said Dr. Petak, who is director of
The Food and Drug Administration porosis center at the Texas Institute for Re-
2.2%, respectively, were seen in the control
tions for males, this approval will enable
groups was statistically significant, Dr.
osteoporosis is 35 mg taken once a week.
patients in the risedronate-treated patients
Risedronate, an oral bisphosphonate first
ages of 36 and 84 to receive either 35 mg
risedronate once a week, or placebo. Dur-
months, respectively, while a mean change
ing the study, all patients received daily
of 0.4% seen in controls at 12 months re-
ticoid-induced osteoporosis and Paget’s
differences, too, were statistically signifi-
disease. It is the second of the three oral
statistically significant difference of 4.53%
those receiving only the vitamin D and cal-
Neglected bones: About 2 million U.S.
men reportedly have osteoporosis.
fractures. By 2 years, with 14 and 35 new
to in June, was the largest thus far to eval-
Significant differences also were seen in
fractures in the two groups, respectively,
uate antiresorptive therapy for idiopathic
fracture risk reduction was 61% for those
osteoporosis in men, and the first to use
events. Again, the safety is similar to what
trochanter at months 12 and 24 and at the
to the trial’s principal investigator, Dr.
for Better Bone Health (Procter & Gamble
“Osteoporosis in men is still widely ne-
type I collagen C-telopeptide, type I col-
Pharmaceuticals and Sanofi-Aventis U.S.).
lagen N-telopeptide/creatinine, and bone-
In 2000, risedronate at a 5-mg oral daily
about 2 million men have the condition.
therapy in a prospective open-label trial
dose was approved for preventing and treat-
ing glucocorticoid-induced osteoporosis in
out the study. “Beginning at the first mea-
were below –2.5 at the lumbar spine and
porosis but are close to developing it, the
below –2.0 at the femoral neck, Dr. Johann
treatment with systemic glucocorticoids. It
is also approved for treating and preventing
million,” he said at the congress.
A total of 158 of the patients received 5
mg risedronate, plus 1,000 mg calcium and
women,” Dr. Boonen said in an interview.
800 IU vitamin D, daily for 2 years. Among
every day, and for treating Paget’s disease
teoporosis and to treat those at risk for
of the bone at an oral dose of 30 mg once
fractures,” added Dr. Boonen, professor of
dronate and those receiving placebo, with
were given the alfacalcidol form of vita-
and 73% of the groups, respectively. A to-
ly, while those without vertebral fractures
were treated with 800 IU plain vitamin D,
gists, welcomed the approval. “It is of
Single-Dose Zoledronic Acid Effective, Safe in Osteoporosis
B Y N A N C Y W A L S H
gen (NTx) fell from 46.1 to 15.2 nmol bone
chest pain) and by three patients in the al-
endronate group (one patella fracture and
T O R O N T O — A single intravenous dose
the alendronate group at 1 week. This rel-
ative change from baseline in NTx was sig-
zoledronic acid group and 86% of those in
Dr. Kenneth Saag reported in a poster ses-
Zoledronic acid is
pants expressing a “strong preference” for
sion at a world congress on osteoporosis.
the most powerful
weekly regimen (66% versus 20%), Dr.
available, and its
long duration of
effect now has
aged 45-79 years to a single infusion of 5
adverse events during the 3 days following
ogy, University of Alabama, Birmingham.
preference for the single-dose treatment,
received oral placebo, and those receiving
according to Dr. Lindsay of the clinical re-
the adverse event rates were similar in the
search center, Helen Hayes Hospital, West
line through week 24 in both groups.
While reductions in BASP levels were sig-
cross-linked N-telopeptide of type I colla-
nificantly greater in the zoledronic acid
two patients in the zoledronic acid group
Chapter 16 Solving Differential Equations This chapter describes how to solve both ordinary and partial differential equations having real-valued solutions. Mathcad Standard comes with the rkfixed function, a general-purpose Runge-Kutta solver that can be used on n th order differential equations with initial conditions or on systems of differential equations. Mathcad Professional includes a
Keynote address presented at the conference, “Building Bridges for Wellness Through Counseling and Psychotherapy,” Sampurna Montfort College, Bangalore, INDIA, Disease Entity or Culture-Bound Syndrome? The Troubled History of DSM-IV’s Major Depressive Disorder Richard Noll, Ph.D. Associate Professor of Psychology DeSales University Center Valley, PA 18034-9568 rich