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Nfcr.org
Research For A Cure A newsletter of the National Foundation for Cancer Research New Progress in Cancer Research - Michael Wang, M.D., Ph.D. Each year, over 50,000
confronted with cancer is the ability for
with other types of cancer. With NFCR’s
Center in California, is working to raise
modification, the T-cells are returned to
today about your suitability for clinical
locating and destroying the cancer cells.
information on Dr. Cooper’s research visit
heard to say “the body makes its ownmedicine.” They were referring to theamazing ability of our body’s immune
Year End Giving
system to heal and defend us fromwithin. However, even the best defensesneed a little reinforcement when a
particularly powerful foe, such as cancer,
donation to NFCR’s cancer research. years to come. If you’re planning forthe future, don’t overlook the benefitsof tax-deductible gifts! Charitable giftannuities, gifts of stock and bequestsare all important considerations in
4600 East West Highway ■ Suite 525 ■ Bethesda, MD 20814 ■ 1-800-321-CURE(2873) ■ www.NFCR.org
President’s Message
centers and more than 30 individual laboratories.
The progress they’ve made and the opportunities at
first Holiday edition of Research for
hand are more exciting than ever, and you have
a Cure. In it you’ll find recent updates on
our research programs, a new paradigm for
To help keep you informed about the advances
you are supporting, we will be expanding our
make tax-wise, year-end gifts, a delicious
newsletter to four editions in 2005. I hope you will
continue to read them and provide us with your
valuable feedback. Thank you so much for your
NFCR. Over the last three months we’ve received
annual progress reports from our nine research
A Toast to Your Health - Sophia Teng, M.A. The relatively low incidence of heart disease among the development of tumor cells.
French, whose diet contains high levels of saturated fat,
A recent study by Drs. Marty Mayo and Fan Yeung at the
is commonly known as the French Paradox. Many have
University of Virginia demonstrated that resveratrol can
attributed this phenomenon to their consumption of red wine.
facilitate the initiation of cancer cells’ self-destruction by
We know now that resveratrol, a compound found in the skins
inhibiting the activity of nuclear factor-kappa B (NF-kB),
which activates genes critical for cell survival. Additionally,
its minimal toxicity to blood-forming cells makes it an
appealing candidate as an anti-cancer agent.
Although present in foods such as mulberries and peanuts,
resveratrol can be found most abundantly in the skins of red
fermentation process of wine making.
fungus invasion. It is also an antioxidant that can inhibit
lipid peroxidation of Low-Density Lipoprotein (LDL), which
plays an important role in preventing the occurrence of heart
production. Of the different types of red wine, resveratrol
disease. Resveratrol also appears to intervene in cancer
concentration is the highest in pinot noir, followed by
progression by inhibiting enzymes such as COX-1 and
cabernet Franc, merlot, and it varies greatly in cabernet
ribonucleotide reductase which play important roles in the
sauvignon. Grape juice, which is not a fermented beverage, isnot a significant source of resveratrol.
While there are many known benefits associated with
Subscribe to Survive !
resveratrol, doctors do not encourage heavy intake ofresveratrol supplements, nor do they recommend a population-wide red wine consumption increase. Currently, we have
to your cancer care needs iscritical! That is why NFCR
limited knowledge about the absorption and clearance of
resveratrol, the identities of its metabolic products, and its
effects on the liver. Therefore, you should consult with your
physician first to determine the amount of wine intake that
can offer you the most health benefits. ■
material, to deliver cancer-specific newsletters on colon,
NFCR’s website, www.NFCR.org is an excellent
source for obtaining information on cancer
prevention tips, new breakthroughs in cancer
issues that concern you. Visit our website
today and register to receive NFCR’s free
New Frontiers in Cancer Drug Development Targeted Therapies: A New Paradigm for Treating Cancer
NFCR Fellow, Dr. Stanley Cohen at Stanford
University School of Medicine is a leadingresearcher in the field of cancer molecular
Biofunding Summit 2004 in October, OSIPharmaceutical’s Colin Goddard, Ph.D.
described clinical trial results which showed
homozygous knockout (RHKO) technology that
identifies, isolates, and characterizes genes that
Pharmaceutical’s Tarceva™, provides a “one-two”
Today, with NFCR’s support, Dr. Cohen’s research
(NSCLC), the nation’s leading cancer killer. And
is focusing on understanding and curing liver
that’s not all: results of a phase III clinical trial
cancer using microarray (gene chip) technology.
Microarray is a technology that can analyze gene
another anti-cancer drug, gemcitabine, also
expressions by identifying differences in biological
properties between normal and cancerous tissues.
Dr. Daniel Von Hoff, Co-Director of the NFCR
Dr. Cohen and his team have identified 703 genes that are highly expressed
Center for New Therapy Development remarked
in liver cancer. Many of those 703 genes have biological functions related to
that these combinations represent a "targeted
cell proliferation, cell cycle control, DNA repair, or RNA transcription – all
therapy" approach that focuses on the abnormal
important steps involved in cancer formation. Researchers can now identify
signals that drive cancer cells and lead to the
tumor markers, cancer promoting genes, and therapeutic targets for liver
cancers. Targeted therapies try to reduce
Why are Dr. Cohen’s recent discoveries so important? Liver cancer is one
tumors and keep cancer at bay by blocking the
of the leading causes of cancer death in the world today. Dr. Cohen’s
process by which cancer cells divide, grow and
comprehensive approach to analyzing gene expression has allowed scientists
spread. Because targeted therapies potentially
to quickly extract more detailed information from limited sets of data,
target cancer cells while sparing healthy cells,
accelerating the pace at which better diagnostics and treatments will become
there is great hope for them as a new and more
available to help liver cancer patients.
effective way to treat cancers with fewer side
Until a cure for liver cancer is found, prevention and early detection are
still your best defense - if you smoke, quit; and limit alcohol intake. If
you’re traveling abroad, make sure to have your Hepatitis B & C vaccinationscompleted. Call NFCR today at 1-800-321-2873 to receive a free Liver CancerFAQ booklet. ■
Giving and Receiving – A Holiday Tradition Order your Poinsettias for the Holidays and help
With a charitable gift annuity, you will:
Receive fixed payments, guaranteed for life benefit cancer research Earn an immediate income tax deduction Support life-saving cancer research
of every purchase of a Poinsettia or one of
arrangements goes to benefit the National
You can direct payments to yourself,An Integrated Approach to Treating Cancer
provide solid scientific evidence and shed light on
how these approaches work against cancer.
(CAM) to combat cancer. In one year alone, it
NFCR supports research that utilizes advanced
was reported in the Journal of the American Medical
technology to develop new anti-cancer therapies from
Association that Americans spent upwards of $21.2
natural herbal substances while following FDA clinical
billion on complementary and alternative medicine
protocols. NFCR Fellow, Dr. Yung-Chi Cheng at Yale
therapies. Not currently regulated by the FDA, these
University School of Medicine is exploring the use of
approaches include dietary supplements, megadose
a Chinese medicine formula as complementary therapy
vitamins, herbal preparations, acupuncture and other
for the treatment of liver cancer. Dr. Cheng has
non-conventional ways to seek help from cancer.
discovered that when used in combination with
available drugs, such as Xeloda, this formula can
researchers have begun to apply the same standards
decrease side effects while enhancing its cancer-
of scientific rigor required for conventional medical
fighting effectiveness. Please be sure to consult your
treatments. One such integrative medical approach
physician before taking any natural remedies or
combines cutting-edge technologies such as
natural products. Not all natural remedies and
proteomics and combinatorial chemistry with CAM to
products are compatible with chemotherapies. ■
A Gift That Lives On… Holiday Treat - Apple Maple Brined Turkey Prep Time: 30 minutes, plus 12-18 hours brining time
prepare to celebrate with our family andloved ones. Unfortunately for many
families, the season may also bring a sense of
loss as we remember those who are no longer
celebrating with us. Many people want to do
something meaningful to honor that person’s
1 Tbsp. coarsely cracked black pepper 6 whole cloves
Fund to paytribute to someone who is battling cancer or
has lost their fight against this terrible
Boil 2 cups of water with salt. Cool to room temperature, and then pour
into a large, tall stock pot or sterilized food grade pail just wide enough
individual you specify and will serve as a
to hold the turkey. Stir in remaining ingredients, except turkey. Set the
lasting tribute to your loved one, and an
turkey in ensuring it is completely submerged in the brine. Refrigerate
ongoing source of support for cancer research.
turkey in brine for 12-18 hours, turning occasionally. Preheat the oven to
Some of our donors have chosen to ask their
325°F. Drain turkey well; discard brine. Pat turkey dry inside and out.
family to make gifts to a Rose Fund in lieu of
Place the turkey in a roasting pan. Roast turkey, basting with pan juices
holiday gifts. Others choose to simply make a
occasionally, 3 hours, or until a thermometer inserted into thickest part of
gift in honor of someone special, intending to
thigh registers 180°F. Rest the turkey 15 minutes before carving. Make
occasions in the future. Still others take thisopportunity to begin making monthly
Recipe courtesy of Thriftyfoods (www.thriftyfoods.com) ■
donations through a named Rose Fund to helpsupport cancer research so others may one day
Want More Healthy and Delicious Recipes?
live without fear of this terrible disease.
Eating healthy is a primary way to reduce your risk of cancer. As a special
There is no limit to the number of people
thank you for your support of NFCR, we are offering a free 2005 “To Your
who can contribute to your Rose Fund, and
Health” Calendar, full of cancer fighting recipes, to anyone who makes a
you can set up separate funds for different
gift of $15 or more. Simply check the box on the reply envelope to receive
establishing a Rose Fund, call Ann Mariani, our
Offer valid while supplies last. Thank you for your contribution to cancer research! You can
Rose Fund specialist, at 800-321-2873. ■
also view our 2005 recipe collection by visiting us at www.NFCR.org. ■
REVISIÓN EL CONTROL ANTIDOPAJE DE LOS JUEGOS OLÍMPICOS: DE LOS ANGELES (1984) A ATENAS (2004) EL CONTROL ANTIDOPAJE DE LOS JUEGOS OLÍMPICOS: DE LOS ANGELES (1984) A ATENAS (2004) OLYMPIC GAMES DOPING CONTROL: FROM LOS ANGELES (1894) TO ATHENS (2004) INTRODUCCIÓN to. El Príncipe Alexandre de Merode, de gran Eduardo Henrique recuerdo, fundador y presidente de esa Com
TOUR I DUE VOLTI DI CIPRO 1° giorno - ITALIA/LARNACA/AYIA NAPA Partenza dall’Italia per Larnaca, con voli di linea diretti. All’arrivo trasferimento all’hotel prescelto di Ayia Napa. Cena e pernottamento. 2° giorno - AYIA NAPA Prima colazione. Giornata intera a disposizione per escursioni facoltative o relax in spiaggia. Pranzo, cena e pernottamento in hotel. 3° g