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MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Candida albicans SYNONYM OR CROSS REFERENCE: Candidiasis, Thrush, Moniliasis CHARACTERISTICS: Oval, budding yeast, produces pseudohyphae in culture and in tissues and exudates SECTION II - HEALTH HAZARD PATHOGENICITY: Mycosis of superficial layers of skin or mucous membranes (oral thrush, vulvovaginitis, paronychia, onychomycosis, intertrigo); ulcers or pseudomembranes in esophagus, gastrointestinal tract or bladder; hematogenous dissemination may produce lesions in kidney, spleen, lung, liver, prosthetic cardiac valve, eye, meninges, brain EPIDEMIOLOGY: Worldwide HOST RANGE: Humans INFECTIOUS DOSE: Unknown MODE OF TRANSMISSION: Endogenous spread (part of normal human flora); by contact with excretions of mouth, skin, and feces from patients or carriers; from mother to infant during childbirth; disseminated candidiasis may originate from mucosal lesions, unsterile narcotic injections, catheters INCUBATION PERIOD: Variable COMMUNICABILITY: Communicable for duration of lesions SECTION III - DISSEMINATION RESERVOIR: Humans (normal human flora) ZOONOSIS: None VECTORS: None SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: Sensitive to nystatin, clotrimazole, ketoconazole, fluconazole, amphotericin B for invasive candidiasis DRUG RESISTANCE: Resistant strains have been described for all the above antifungal drugs SUSCEPTIBILITY TO DISINFECTANTS: Sensitive to 1% sodium hypochlorite, 2% glutaraldehyde, formaldehyde; only moderately sensitive to 70% ethanol
PHYSICAL INACTIVATION: Inactivated by moist heat (121°C for at least 15 min) SURVIVAL OUTSIDE HOST: Survives outside of host, especially in moist, dark areas SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms; microscopic demonstration of pseudohyphae and/or yeast cells in infected tissue or fluid; confirmation by culture FIRST AID/TREATMENT: Administer antibiotic therapy as required IMMUNIZATION: None PROPHYLAXIS: None SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: 2 reported laboratory-acquired infections with Candida SOURCES/SPECIMENS: Sputum, bronchial washings, stool, urine, mucosal surfaces, skin or wound exudates, CSF, blood PRIMARY HAZARDS: Accidental parenteral inoculation, exposure of mucous membranes to droplets and aerosols, ingestion SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment equipment and facilities for the manipulation of this organism PROTECTIVE CLOTHING: Laboratory coat; gloves when contact with infectious materials is unavoidable OTHER PRECAUTIONS: None SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill with absorbent paper towel and apply 1% sodium hypochlorite, starting at perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: November 1999 Prepared by: Office of Laboratory Security, PHAC
Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date.
PARECER HOMOLOGADO(*) (*) Despacho do Ministro, publicado no Diário Oficial da União de 14/01/2009 MINISTÉRIO DA EDUCAÇÃO CONSELHO NACIONAL DE EDUCAÇÃO INTERESSADO: André Gustavo de Oliveira Tavares ASSUNTO: Autorização para cursar o período do internato do curso de Medicina, ministrado na Faculdade de Medicina de Valença – FMV, de Valença/RJ, no Hospital Ana Costa