Separation and Quantitation of R and SEnantiomers using Normal PhaseChromatography on an API 3000™LC/MS/MS System Normal phase chromatography can
strates that it is possible to safely and be used for the analysis of chiral
compounds using the API 3000™
LC/MS/MS System.
Key Features
Figure 1. Verapamil calibration curves for enantiomer R and S.
Figure 2. Methylphenidate calibration curves for enantiomer R and S.
Experimental Conditions
APCI (Nitrogen gas used for all connections) animals dosed with racemic mixtures.
the coronary vasodilator, verapamil.
Figure 3. Fluoxetine calibration curves for enantiomer R and S.
Figure 4. Verapamil, 0.1 ng/mL racemate concentration, extracted from
Figure 5. Methylphenidate, 0.1 ng/mL racemate concentration,
rat plasma.
extracted from rat plasma.
Results and Discussion
centration range of 0–1,000 ng/mL.
separation, approximately 65 minutes.
Worldwide Sales Offices
Applied Biosystems vast distribution
office locations, please call the division at www.appliedbiosystems.com.
Figure 6. Fluoxetine, 100 ng/mL racemate concentration, extracted from rat
plasma and fluoxetine, 10 ng/mL racemate concentration, extracted from rat
plasma plus integrating a switching valve to overcome mobile phase incom-

patibility. Note that the intensity is comparable despite the ten-fold
decrease in analyte concentration.
Not for use in diagnostic procedures.
Applied Biosystems is a registered trademarkof Applera Corporation or its subsidiaries in the US and certain other countries. MDS and SCIEX are trademarks of MDS Inc.
Prozac is a registered trademark of Eli Lilly and company.
Ciba-Geigy Corporation.
Daicel is a trademark and Chiralpak is a registered trademark of Daicel ChemicalIndustries, Ltd.
Sigma is a registered trademark of Sigma Chemical Company.
2000 Applied Biosystems. All rights reserved. Information subject to change without notice. Printed in the USA, 12/2000, BHLPublication 114AP12-01 www.appliedbiosystems.com

Source: http://www3.appliedbiosystems.com/cms/groups/psm_marketing/documents/generaldocuments/cms_039792.pdf

003056 1.5

sollte die Antikoagulation solange erfolgen,frühes Absetzen vergrößert die Thrombose-gefahr. Nach Operationen und Geburtensollte Marcumar vom 2. oder 3. Tag an ge-höhtes Risiko für thromboem-bolische Ereignisse gegebenhender Embolie ist die Einleitung der Anti-Die vollständige Auflistung der sonstigenHerzklappenersatz, biologisch 2,0 bis 3,0koagulanzientherapie durch intravenöse Ap

History new knee sports (14198

Sports Knee Patient History © 1998-2008, Sparrow Systems, Inc., Patent Pending If you are seeing us for more than one problem, which ONE is the worst?Please describe your current problem (If you are seeing the doctor for multiple problems, answer for the most severe)New Injury or problem (less than 6 weeks duration)Subacute problem (began slowly with no identifiable cause and progressively

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