Resources to guide effective professional practice: jognn special reports new resources for evidence-based practice, carol sakala, phd, msph, january/february 2004
SPECIAL REPORTS Resources for Evidence-Based Practice, January/February 2004 Carol Sakala
Published simultaneously in Journal of Midwifery Comment: Continuous labor support has no
and Women’s Health (2004); 49(1).
known downsides and can help women have a satis-fying childbirth experience and avoid risks associat-
This column highlights new and recently updated
ed with cesareans and other major interventions.
systematic reviews and overviews of best research
The organization of care in modern maternity units
evidence that clarify knowledge about effects of spe-
appears to limit the effectiveness of labor support
cific practices in maternal/newborn and women’s
provided by members of the hospital staff. It is a pri-
ority to clarify whether this basic component of safeand effective maternity care also offers economic
From Cochrane Database of Systematic
advantages. Full text of the review is available with-out charge from http://www.maternitywise.org/
Reviews (CDSR), Issue 3, 2003 Featured review: Hodnett, E. D., Gates, S., Hofmeyr, G. J., & Sakala, C. Continuous support New Systematic Reviews for women during childbirth.
• Amniocentesis and chorionic villus sampling
The Cochrane labor support review has been
entirely reconstructed with the following new ele-
• Deep versus shallow suction of endotracheal
ments: reviewer team, title, protocol, large random-
tubes in ventilated neonates and young infants
ized controlled trials (RCTs), and subgroup analy-
• Early intravenous nutrition for the prevention
ses. It also includes expanded background and
discussion sections. The new review summarizes
• G-CSF and GM-CSF for treating or preventing
experiences of nearly 13,000 women who partici-
pated in 15 RCTs. Women who received continuous
• Gowning by attendants and visitors in new-
labor support were less likely than women who did
born nurseries for prevention of neonatal mor-
not have continuous labor support to have regional
analgesia or any analgesia/anesthesia, give birth with
• Male circumcision for prevention of heterosex-
vacuum extraction or forceps, give birth by cesare-
an, and report dissatisfaction or negatively rate their
• Oestrogen supplementation, mainly diethyl-
experience. A subgroup analysis examined the
stilbestrol, for preventing miscarriages and
impact of the type of person providing continuous
support. Effects were stronger when the person was
• Oral immunoglobulin for the prevention of
not a regular member of the hospital staff and was
rotavirus infection in low birth weight infants
an outsider present expressly to provide support.
• Rectal analgesia for pain from perineal trauma
Compared to women without continuous support,
those with support from nonhospital caregivers were
• Regional (spinal, epidural, caudal) versus gen-
26% less likely to give birth by cesarean section,
eral anaesthesia in preterm infants undergoing
41% less likely to have an instrumental birth, 28%
less likely to use any analgesia or anesthesia, and
• Repeat doses of prenatal corticosteroids for
36% less likely to be dissatisfied with their child-
women at risk of preterm birth for preventing
• Surgical versus medical treatment with
cyclooxygenase inhibitors for symptomatic patent
compend-babyfriendlywho.htm) provides evidence-based
recommendations for breastfeeding support during hospi-
• Treatments for gestational diabetes and impaired
talization for childbirth. BFHI and the review featured
here together provide guidance to help clinicians effec-
• Vitamin E supplementation for prevention of mor-
tively support breastfeeding throughout the childbearing
cycle. Optimal breastfeeding support in primary care mayrequire services that go beyond routine prenatal and
Updated Systematic Reviews
• Dopamine versus dobutamine for hypotensive
Recent Abstract Entries Assessing Quality
• Growth hormone for in vitro fertilization
of Systematic Reviews
• Oral beta-blockers for mild to moderate hyperten-
• Accuracy of outpatient endometrial biopsy in the
diagnosis of endometrial cancer: a systematic quan-
• Ovulation suppression for endometriosis
• Phenobarbital prior to preterm birth for preventing
• Are fluid-based cytologies superior to the conven-
tional Papanicolaou test: a systematic review
• Planned cesarean section for term breech delivery
• Diagnostic accuracy of large-core needle biopsy for
• Support during pregnancy for women at increased
nonpalpable breast disease: a meta-analysis
• Efficacy of physical therapy methods and exercise
after a breast cancer operation: a systematic review
• Fetal bradycardia due to intrathecal opioids for
Cochrane Reviews are available by subscription to TheCochrane Library or through various publishing partners.
• Laparoscopic surgery is not inherently dangerous
Abstracts of Cochrane Reviews are available without
for patients presenting with benign gynaecologic
charge. See http://www.cochrane.org/reviews/ for abstracts
• Luteal phase support in infertility treatment: a meta-
From Database of Abstracts of Reviews of
• Management of mild chronic hypertension during
Effects (DARE)
• Patient-controlled epidural analgesia versus contin-
Featured review: Couto de Oliveira, M. I., Bastos
uous infusion for labour analgesia: a meta-analysis
Camacho, & L. A., Tedstone, A. E. Extending breast-
• Psychological consequences of predictive genetic
feeding duration through primary care: a systematic review of prenatal and postnatal interventions. [Abstract
• Tolterodine versus oxybutynin in the treatment of
20025027]
urge urinary incontinence: a meta-analysis
This review of prenatal and/or postpartum interven-
• US characterization of ovarian masses: a meta-
tions was performed to determine effective ways to pro-
mote, protect, and support breastfeeding within primarycare. The authors report results from 27 internally valid
DARE abstracts are available without charge from
randomized controlled trials and 10 internally valid
quasi-random studies enrolling a total of 20,253 women. The most effective interventions tended to span the pre-
Evidence-Based Reviews From Other Sources
natal period or both prenatal and postpartum periods andto offer face-to-face information, guidance, and support. Featured review: (May 2003). Results of systematic
The research supports intensive interventions that com-
review of research on diagnosis and treatment of coro-
bine group sessions, individual sessions, and/or home vis-
nary heart disease in women; summary. Evidence
its over time. It does not support breastfeeding promotion
Report/Technology Assessment: Number 80. AHRQ Pub-
with mixed messages (e.g., concurrent with providing
lication Number 03-E034. Rockville, MD: Agency for
infant formula) and brief nonintensive interventions
Healthcare Research and Quality. Available without
(including giving breastfeeding messages among other
charge at: http://www.ahrq.gov/clinic/epcindex.htm#
topics and through isolated printed materials). The
gynecologic. DARE abstract authors give a high rating to the overall
Although coronary heart disease (CHD) is the most
common cause of death in women, most CHD research
Comment: The WHO/UNICEF Baby-Friendly Hospi-
reports do not provide useful data about its prevention
tal Initiative (BFHI, see http://www.cdc.gov/breastfeeding/
diagnosis and treatment in women. The Agency for
Healthcare Research and Quality commissioned this evi-
AHRQ Publication No. 03-E036. Rockville, MD:
dence overview to assess the best available research about
Agency for Healthcare Research and Quality. Avail-
women with a focus on 1) accurate noninvasive tests for
able without charge and with full report at
identifying CHD; 2) effective treatments for CHD; 3) risk
http://www.ahrq.gov/clinic/epcindex.htm#cardiovascular.
factors for CHD and effects of modifying these; 4) relative
• Farquhar, C., Ekeroma, A., Furness, S., & Arroll, B.
use of tests, risk factor modification, and treatments in
(2003). A systematic review of transvaginal ultra-
women and men; and 5) prognostic value of biochemical
sonography, sonohysterography and hysteroscopy
markers for diagnosing acute myocardial infarction or
for the investigation of abnormal uterine bleeding in
unstable angina. This comprehensive search for evidence
premenopausal women. Acta Obstetricia et Gyne-
focused on 42 specified subtopics and yielded just 162
cologica Scandinavica, 82(6), 493-504.
useable articles. Most articles used less definitive observa-
• Fraser. A. B., & Grimes, D. A. (2003). Effect of lac-
tional designs (versus experimental designs or systematic
tation on maternal body weight: A systematic
reviews), and good-quality data were only available to
review. Obstetrical and Gynecological Survey,
address six of the subtopics. For specific details on the
quality and results of currently available research, readers
• Green, B. B., & Taplin, S. H. (2003). Breast cancer
are referred to the summary and full report, available
screening controversies. Journal of the AmericanBoard of Family Practice, 16(3), 233-241. Comment: .Although federal policies have succeeded in
• Green, J., Berrington de Gonzalez, A., Smith, J. S.,
increasing the proportion of female participants in
Franceschi, S., Appleby, P., Plummer, M., & Beral,
research, few subgroup results or focused studies are
V. (2003). Human papillomavirus infection and use
available to guide practice for women relating to these
of oral contraceptives. British Journal of Cancer,
• Harvey, M. A. (2003). Pelvic floor exercises during
Recent Evidence-Based Reviews
and after pregnancy: A systematic review of their
• Bachmann, L. M., Coomarasamy, A., Honest, H., &
role in preventing pelvic floor dysfunction. Journal
Khan, K. S. (2003). Elective cervical cerclage for
of Obstetrics and Gynaecology Canada, 25(6), 487-
prevention of preterm birth: A systematic review. Acta Obstetricia et Gynecologica Scandinavica,
• Kroumpouzos, G., & Cohen, L. M. (2003). Specific
dermatoses of pregnancy: An evidence-based sys-
• Barnhart, K. T., Gosman, G., Ashby, R., & Sammel,
tematic review. American Journal of Obstetrics and
M. (2003). The medical management of ectopic
Gynecology, 188(4), 1083-1092.
pregnancy: A meta-analysis comparing “single
• Malik, A., Hui, C. P., Pennie, R. A., & Kirpalani, H.
dose” and “multidose” regimens. Obstetrics and
(2003). Beyond the complete blood cell count and
Gynecology, 101(4), 778-784.
C-reactive protein: A systematic review of modern
• Berkman, N. D., Thorp, J. M., Lohr, K. N., Carey,
diagnostic tests for neonatal sepsis. Archives of
T. S., Hartmann, K. E., Gavin, N. I., Hasselblad, V.,
Pediatrics and Adolescent Medicine, 157(6), 511-
& Idicula, A. E. (2003). Tocolytic treatment for the
management of preterm labor: A review of the evi-
• Merialdi, M., Carroli, G., Villar, J., Abalos, E., Gul-
dence. American Journal of Obstetrics and Gyne-
mezoglu, A. M., Kulier, R., & de Onis, M. (2003). cology, 188(6), 1648-1659.
Nutritional interventions during pregnancy for the
• Carfoot, S., Williamson, P. R., & Dickson, R.
prevention or treatment of impaired fetal growth:
(2003). A systematic review of randomised con-
An overview of randomized controlled trials. Jour-
trolled trials evaluating the effect of mother/baby
nal of Nutrition, 133(5 Suppl 2), 1626s-1631s.
skin-to-skin care on successful breast feeding. Mid-
• Pritchard, M. A., Flenady, V., & Woodgate, P. wifery, 19(2), 148-155.
(2003). Systematic review of the role of pre-
• Coomarasamy, A., Honest, H., Papaioannou, S.,
oxygenation for tracheal suctioning in ventilated
Gee, H., & Khan, K. S. (2003). Aspirin for preven-
newborn infants. Journal of Paediatrics and Child
tion of preeclampsia in women with historical risk
Health, 39(3), 163-165.
factors: A systematic review. Obstetrics and Gyne-
• Ray, J. G., & Blom, H. J. (2003). Vitamin B12 insuf-
cology, 101(6), 1319-1332.
ficiency and the risk of fetal neural tube defects.
• (May 2003). Diagnosis and treatment of coronary
Quality Journal of Medicine, 96(4), 289-295.
heart disease in women: Systematic reviews of evi-
• Rietman, J. S., Dijkstra. P. U., Hoekstra, H. J.,
dence on selected topics; summary. Evidence
Eisma, W. H., Szabo, B. G., Groothoff, J. W., &
Report/Technology Assessment: Number 81.
Geertzen, J. H. (2003). Late morbidity after treat-
ment of breast cancer in relation to daily activities
their knowledge and increase their participation in deci-
and quality of life: A systematic review. European
sion making? Does editorial peer review improve the
Journal of Surgical Oncology, 29(3), 229-238.
quality of reports of biomedical studies? A growing num-
• Sanchez-Ramos, L., Olivier, F., Delke, I., & Kaunitz,
ber of systematic reviews are available to help clarify
A. M. (2003). Labor induction versus expectant
results of the best available research about these and other
management for postterm pregnancies: A systemat-
questions relating to effective professional practice and
ic review with meta-analysis. Obstetrics and Gyne-cology, 101(6):1312-1318.
Within the Cochrane Collaboration, three review
• Smith, J. S., Green, J., Berrington de Gonzalez, A.,
groups prepare and maintain systematic reviews in this
Appleby, P., Peto, J., Plummer, M., Franceschi, S., &
broad area. The Effective Practice and Organization of
Beral, V. (2003). Cervical cancer and use of hor-
Care Group evaluates continuing education, regulatory,
monal contraceptives: A systematic review. The
organizational, quality assurance, and other interventions
Lancet, 361, 1159-1167.
to improve service delivery. The Consumers and Commu-
• Van Kessel, K., Assefi, N., Marrazzo, J., & Eckert,
nication Group evaluates interventions that affect con-
L. (2003). Common complementary and alternative
sumers’ interactions with health professionals, services,
therapies for yeast vaginitis and bacterial vaginosis:
and researchers; and the Methodology Review Group
A systematic review. Obstetrical and Gynecological
evaluates aspects of carrying out research and disseminat-
Survey, 58(5), 351-358.
ing research results. Issue 4, 2003 of The Cochrane
• Villar, J., Merialdi, M., Gulmezoglu, A. M., Abalos,
Library includes 48 completed systematic reviews from
E., Carroli, G., Kulier, R., & de Onis, M. (2003).
these groups and 42 protocols of additional reviews in
Nutritional interventions during pregnancy for the
preparation. The Cochrane Collaboration Web site
prevention or treatment of maternal morbidity and
(http://www.cochrane.org/) contains abstracts of complet-
preterm delivery: An overview of randomized con-
ed reviews and titles of reviews under development from
trolled trials. Journal of Nutrition, 133(5 Suppl 2),
these groups, along with links to their Web sites and PDF
files of their newsletters. These resources can help policy
• Yabroff, K. R., Mangan, P., & Mandelblatt, J.
makers, administrators, educators, researchers, and clini-
(2003). Effectiveness of interventions to increase
Papanicolaou smear use. Journal of the AmericanBoard of Family Practice, 16(3), 188-203. Carol Sakala, PhD, MSPH, is Director of Programs at the Commentary: Resources to Guide Effective Maternity Center Association (MCA). MCA’s long-term nation- Professional Practice al Maternity Wise program works with health professionals and other audiences to promote evidence-based maternity care
Do continuing education meetings improve profession-
(http://www.maternitywise.org). E-mail: sakala@maternity-
al practice and health outcomes? Do decision aids for
wise.org.
people facing treatment or screening decisions improve
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Comparison of 2 D Similarity and 3 D Superposition. Application to Searching a Conformational Drug Database Martin Thimm,*,† Andrean Goede,‡ Stefan Hougardy,† and Robert Preissner‡Institut fu¨r Informatik, Humboldt-Universita¨t zu Berlin, 10099 Berlin, Germany, and Institut fu¨r Biochemie,Charite´, Monbijoustrasse 2, 10117 Berlin, GermanyIn a database of about 2000 appro