Enfin disponible en France, grâce à une étonnante formule France, 100% naturelle, vous pouvez maintenant dire stop à vos problèmes d’impuissance et à vos troubles de la virilité. Cette formule révolutionnaire agit comme un véritable achat levitra naturel. Ses résultats sont immédiats, sans aucun effet secondaire et vos érections sont durables, quelque soit votre âge. Même si vous avez plus de 50 ans !


The Scientist - Antibiotic Corrects Genetic Glitch The Scientist 15[8]:16, Apr. 16, 2001
Antibiotic Corrects Genetic Glitch
By Ricki Lewis
Antibiotics that enable ribosomes to "read through" premature stop codons (nonsense mutations), which truncate proteins, may kick-start a new approach to gene therapy. A team of researchers from the University of Alabama at Birmingham and from the Women's and Children's Hospital in South Australia applied a long-ago observation about the antibiotic gentamicin on ribosomes to correct the enzyme deficiency that causes Hurler syndrome, in cultured fibroblasts from patients.1 The antibiotic apparently enables ribosomes to zip past nonsense mutations,
in which a single base substitution converts an amino-acid encoding codon into a stop codon, shortening the
protein product. "It's been known since the early 1960s that aminoglycoside antibiotics bind the 16S bacterial
ribosomal RNA subunit, affecting translational fidelity, causing read-through of stop codons in bacteria. In
mammalian ribosomes, the region is similar but it has a lower binding affinity, and that's why these antibiotics kill
bacteria before they kill people. We show that the concentrations of antibiotic used clinically to kill bacteria are
tweaking mammalian ribosomes," explains David M.
Bedwell associate professor of microbiology at the
The symptoms of Hurler syndrome--mental retardation, dwarfism, hearing loss, enlarged liver and spleen, and cardiac and respiratory problems--stem from deficiency of alpha-L-iduronidase, which normally breaks down glycosaminoglycans (a type of mucopolysaccharide) in the lysosomes of fibroblasts and white blood cells. Just a modest boost in enzyme production can lessen the severity of symptoms, but attempts at enzyme replacement therapy have failed. The researchers focused on Hurler syndrome because nearly two-thirds of the known mutations are nonsense. However, the investigators and others have also used the antibiotic to suppress nonsense mutations in cells from patients with cystic fibrosis,4 and in mice with muscular dystrophy.5 "This approach has tremendous potential. Aminoglycosides are just one type of antibiotic, and it works," says Bedwell. PTC Therapeutics of South Plainfield, NJ, is one step ahead--they are using high throughput assays to discover variations on the gentamicin theme that do not bring the side effects of kidney and ear toxicity.
Bedwell likens this new use for an old drug to the Viagra saga, where "a funny side effect led to a huge new market. You have to keep your eyes open and if you know the molecular mechanism, you can zero in on a treatment." References
1. K. Keeling et al., "Gentamicin-mediated suppression of Hurler syndrome stop mutations leads to a partial restoration of a-L-iduronidase
activity and a reduction of lysosomal glycosaminoglycan accumulation,"
2. J. Davies et al., "Misreading of RNA codewords induced by aminoglycoside antibiotics," 3. E.M. Lederberg et al., "Interaction of streptomycin and a suppressor for galactose fermentation in E. coli K-12," Proceedings of the 4. M. Wilschanski et al., "A pilot study of the effect of gentamicin on nasal potential difference measurements in cystic fibrosis patients carrying stop mutations," American Journal of Respiratory Critical Care Medicine 5. E.R. Barton-Davis et al., "Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice," Journal of Clinical The Scientist 15[8]:16, Apr. 16, 2001
http://www.the-scientist.com/yr2001/apr/research1_010416.html The Scientist - Antibiotic Corrects Genetic Glitch We welcome your opinion. If you would like to comment on this article, please write us at editorial@the-scientist.com
Opinions & Letters
Research Hot Papers
Profession About
The Scientist Jobs
Web Registration
Print Subscriptions Advertiser Information

Source: http://www.microbio.uab.edu/bedwell/TheScientist.pdf

Controlled substance

Title 21 United States Code (USC) Controlled Substances Act Section 812. Schedules of Controlled Substances There are established five schedules of controlled substances, to be known as schedules I, II, III, IV, and V. Such schedules shall initially consist of the substances listed in this section. The schedules established by this section shall be updated and republished on a semiannu

Microsoft word - 2007lza03 advies geanonimiseerd.doc

van de deskundigencommissie late zwangerschapsafbreking en levensbeëindiging bij pasgeborenen betreffende de melding van: de heer / mevrouw naam, gynaecoloog gevestigd te plaatsnaam verder te noemen: de arts betreffende: mevrouw naam, geboren op dag maand jaar, verder te noemen: de moeder. PROCEDURE Op 27 augustus 2007 heeft de commissie de stukken ontvangen als bedoeld in artikel 10 van

Copyright © 2010-2014 Online pdf catalog