PARENT RATINGS OF BEHAVIORAL EFFECTS OF BIOMEDICAL INTERVENTIONS Autism Research Institute ● 4182 Adams Avenue ● San Diego, CA 92116
The parents of autistic children represent a vast and important reservoir of information on the benefits—and adverse effects— of the large variety of drugs and other interventions that have been tried with their children. Since 1967 the Autism Research Institute has been collecting parent ratings of the usefulness of the many interventions tried on their autistic children. The following data have been collected from the more than 23,700 parents who have completed our questionnaires designed to collect such information. For the purposes of the present table, the parents responses on a six-point scale have been combined into three categories: “made worse” (ratings 1 and 2), “no effect” (ratings 3 and 4), and “made better” (ratings 5 and 6). The “Better:Worse” column gives the number of children who “Got Better” for each one who “Got Worse.”
Parent Ratings Parent Ratings Parent Ratings Got No Got Better: No. of Got No Got Better: No. of Got No Got Better: No. of WorseA Effect Better Worse CasesB DRUGS WorseA Effect Better Worse CasesB DRUGS WorseA Effect Better Worse CasesB 25% 34% 0.8:1 Desipramine 34% 31% 34% 1.0:1 Phenobarb.D Amphetamine 47% 28% 25% 0.5:1 DilantinD Behavior Anafranil 38% 30% 1.0:1 Behavior Seizures Antibiotics 57% 12% 0.4:1 Seizures Prolixin AntifungalsC Felbatol Diflucan 41% 55% 11:1 Fenfluramine 20% 52% 28% 1.4:1 Risperidal Nystatin 46% 49% 10:1 53% 22% 0.9:1 Secretin Benadryl 51% 25% 1.0:1 Intravenous 7% Beta Blocker 18% 50% 33% 1.9:1 KlonapinD Transderm. 10% 44% 30% 1.1:1 Behavior Stelazine Seizures TegretolD 38% 21% 0.5:1 Behavior Clonidine 31% 47% 2.2:1 Seizures Clozapine 42% 18% 0.4:1 Mellaril Thorazine Cogentin 54% 27% 1.5:1 MysolineD Tofranil 35% 20% 0.4:1 Behavior 56% 30% 2.0:1 Seizures ZarontinD DepakeneD Naltrexone Behavior Behavior 43% 32% 1.2:1 Seizures Seizures 32% 57% 4.8:1 Phenergan BIOMEDICAL/ Parent Ratings BIOMEDICAL/ Parent Ratings NON-DRUG/ Got No Got Better: No. of NON-DRUG/ Got No Got Better: No. of SUPPLEMENTS WorseA Effect Better Worse CasesB SUPPLEMENTS WorseA Effect Better Worse CasesB Vitamin A Vitamin B3 55% 41% 10:1 CalciumE Vit. B6 alone 63% 30% 3.9:1 Cod Liver Oil Vit. B6/Mag. 49% 47% 10:1 Cod Liver Oil with Vitamin B12 33% 63% 15:1 Bethanecol 45% 39% 2.4:1 Vitamin C 57% 41% 18:1 Colostrum 58% 37% 8.1:1 51% 47% 20:1 Detox. (Chelation)C Digestive Enzymes SPECIAL DIETS 51% 42% 5.6:1 Fatty Acids Candida Diet 51% 39% 3.7:1 Feingold Diet Folic Acid Gluten- /Casein- Food Allergy Trtmnt Free Diet Magnesium 65% 29% 4.6:1 Melatonin 30% 61% 7.3:1 Chocolate P5P (Vit. B6) 37% 51% 4.0:1 Removed Eggs 63% 28% 3.2:1 Removed Milk 66% 19% 1.3:1 Products/Dairy St. Johns Wort 64% 21% 1.5:1 Removed Sugar 44% 42% 3.0:1 Removed Wheat Transfer Factor Rotation Diet
A. “Worse” refers only to worse behavior. Drugs, but not nutrients, typically also cause physical problems if used long-term. B. No. of cases is cumulative over several decades, so does not reflect current usage levels (e.g., Haldol is now seldom used). C. Antifungal drugs and chelation are used selectively, where evidence indicates they are needed. D. Seizure drugs: top line behavior effects, bottom line effects on seizures E. Calcium effects are not due to dairy-free diet; statistics are similar for milk drinkers and non-milk drinkers.
Recent developments in mortality We are seeing unprecedented change For men aged 65-74 in England & Wales the reduction in mortality rates over the past 15 years was similar to that achieved over the previous 150 years We are seeing unprecedented change reduction in mortality rates for England & Wales aged (smoothed) We are seeing un